MAPK11 and ATF2

Number of citations of the paper that reports this interaction (PubMedID 15304344)
0

Data Source:
HPRD (in vitro)

		MAPK11	ATF2
Description		mitogen-activated protein kinase 11	activating transcription factor 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Site Of Double-strand Break RNA Polymerase II Transcription Regulator Complex H4 Histone Acetyltransferase Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Histone Acetyltransferase Activity Protein Binding CAMP Response Element Binding Protein Binding Zinc Ion Binding Histone H4 Acetyltransferase Activity Protein Kinase Binding CAMP Response Element Binding Identical Protein Binding Protein Homodimerization Activity Leucine Zipper Domain Binding Sequence-specific DNA Binding Histone H2B Acetyltransferase Activity Metal Ion Binding Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	MAPK Cascade Osteoblast Differentiation Positive Regulation Of Gene Expression Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Interleukin-12 Production Intracellular Signal Transduction P38MAPK Cascade Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Protein Maturation Cardiac Muscle Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Proliferation Bone Development Pyroptotic Inflammatory Response Cellular Response To Interleukin-1 Cellular Response To UV-B Cellular Senescence Cellular Response To Virus NLRP1 Inflammasome Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade In Utero Embryonic Development NK T Cell Differentiation Liver Development Hematopoietic Progenitor Cell Differentiation Outflow Tract Morphogenesis Brainstem Development Growth Plate Cartilage Chondrocyte Differentiation Growth Plate Cartilage Chondrocyte Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Lipid Metabolic Process Apoptotic Process Response To Osmotic Stress DNA Damage Response Vacuole Organization JNK Cascade Heart Development Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Angiogenesis Peptidyl-threonine Phosphorylation Abducens Nucleus Development Hypoglossal Nucleus Development Facial Nucleus Development BMP Signaling Pathway Mitotic Intra-S DNA Damage Checkpoint Signaling Positive Regulation Of Transforming Growth Factor Beta2 Production Cellular Response To Oxidative Stress P38MAPK Cascade MRNA Transcription By RNA Polymerase II Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II White Fat Cell Differentiation Positive Regulation Of DNA-binding Transcription Factor Activity Neurofilament Cytoskeleton Organization Detection Of Cell Density Adipose Tissue Development Cellular Response To Anisomycin Motor Neuron Apoptotic Process Hepatocyte Apoptotic Process Cellular Response To Virus Positive Regulation Of Cardiac Muscle Myoblast Proliferation Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Apoptotic Process Involved In Development Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Cellular Response To Leucine Starvation
Pathways		NOD1/2 Signaling Pathway p38MAPK events p38MAPK events ERK/MAPK targets Activation of PPARGC1A (PGC-1alpha) by phosphorylation Oxidative Stress Induced Senescence VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Activation of the AP-1 family of transcription factors KSRP (KHSRP) binds and destabilizes mRNA Myogenesis Myogenesis RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	Transcriptional activation of mitochondrial biogenesis HATs acetylate histones Activation of the AP-1 family of transcription factors TP53 Regulates Transcription of DNA Repair Genes Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK4 (GCN2) to amino acid deficiency Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2
Drugs		Minocycline KC706 Regorafenib	Pseudoephedrine
Diseases
GWAS		Acne (severe) ( 24927181) Adult body size ( 32376654)	Intake of total sugars ( 31005972) Metabolite levels ( 23823483)
Interacting Genes		28 interacting genes: APP ATF2 BCL2 C9orf78 CCND1 CPNE6 DOT1L DUSP10 DUSP16 EEF2K ELK1 ELK4 ESR2 HDAC3 HTRA2 JUN MAPKAPK5 MAPT MBP NOXA1 PML POLR3D PPM1D RPS6KA5 SH2D1A SOCS3 TAB1 ZNHIT1	61 interacting genes: APP AR ATF3 ATF4 ATF7 BACH1 BANP BATF CCDC6 CCND1 CEBPA CEBPB CEBPG CREB5 CSNK2A1 CSNK2A2 DDIT3 DNMT3L EDF1 ETS1 EXOSC8 FAM13A-AS1 FOS GTF2F2 H2BC21 HMGA1 IRF2BP1 JDP2 JUN KIFC3 LHX8 MACROH2A1 MAPK1 MAPK10 MAPK11 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK5 MLH1 NBN NCOA6 PIAS2 PML PRKCE RB1 RNF4 RPS6KA5 RUVBL2 SMAD3 SMAD4 SPOPL SRA1 SUMO1 THRB UBE2I USP14 UTF1 XPO1 YY1
Entrez ID		5600	1386
HPRD ID		04208	00443
Ensembl ID		ENSG00000185386	ENSG00000115966
Uniprot IDs		Q15759	A4D7V5 P15336
PDB IDs		3GC8 3GC9 3GP0 8YGW	1BHI 1T2K 4H36 6ZQS 6ZR5
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Mitogen-activated Protein Kinase P38 Binding Regulation Of Growth Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of Developmental Growth Chromatin Binding Response To Metal Ion Negative Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Enzyme Binding Regulation Of Neuron Apoptotic Process Regulation Of Signal Transduction Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Regulation Of Multicellular Organism Growth Signal Transduction In Response To DNA Damage Positive Regulation Of RNA Biosynthetic Process Epigenetic Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Positive Regulation Of DNA-templated Transcription Response To Stress Mitogen-activated Protein Kinase Binding Regulation Of Developmental Process Chromatin Remodeling Cellular Response To Anisomycin Nucleus Positive Regulation Of RNA Metabolic Process Protein Serine/threonine Phosphatase Activity Negative Regulation Of Macromolecule Biosynthetic Process Cytosol Microglial Cell Activation Response To Anisomycin Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Leukocyte Activation Involved In Inflammatory Response Nucleoplasm Negative Regulation Of RNA Biosynthetic Process Main Axon Liver Development	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Nucleus Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Intracellular Signal Transduction Intracellular Signaling Cassette Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Enzyme Binding Chromatin Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process MAP Kinase Activity DNA Binding Response To Stress Transcription Cis-regulatory Region Binding Integrated Stress Response Signaling Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity MAPK Cascade RNA Polymerase II-specific DNA-binding Transcription Factor Binding Macromolecule Metabolic Process DNA Damage Response DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cellular Senescence Chromatin Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
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