MAPK11 and CCND1

Number of citations of the paper that reports this interaction (PMID 10952989)
29

Data Source:
BioGRID (enzymatic study)

		MAPK11	CCND1
Gene Name		mitogen-activated protein kinase 11	cyclin D1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol	Cyclin-dependent Protein Kinase Holoenzyme Complex Intracellular Nucleus Nucleoplasm Cytosol Tight Junction Membrane Transcriptional Repressor Complex
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding	Transcription Corepressor Activity Protein Kinase Activity Protein Binding Transcription Factor Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Enzyme Binding Protein Kinase Binding Protein Complex Binding Histone Deacetylase Binding Proline-rich Region Binding
	Biological Process	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Protein Phosphorylation Response To Stress Organelle Organization Mitochondrion Organization Signal Transduction Ras Protein Signal Transduction Gene Expression Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Muscle Cell Differentiation Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Re-entry Into Mitotic Cell Cycle Liver Development Positive Regulation Of Protein Phosphorylation Chromatin Organization Transcription, DNA-templated Protein Phosphorylation Cellular Response To DNA Damage Stimulus Notch Signaling Pathway Lactation Response To Iron Ion Response To X-ray Response To Organonitrogen Compound Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Organ Regeneration Mitotic G1 DNA Damage Checkpoint Response To Magnesium Ion Response To Vitamin E Leydig Cell Differentiation Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Response To Drug Response To Estrogen Fat Cell Differentiation Response To Ethanol Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division Response To Corticosterone Response To Calcium Ion Canonical Wnt Signaling Pathway Mammary Gland Alveolus Development Response To UV-A Negative Regulation Of Cell Cycle Arrest
Pathways		Cellular Senescence Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway p38MAPK events MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets activated TAK1 mediates p38 MAPK activation Regulation of mRNA stability by proteins that bind AU-rich elements CDO in myogenesis TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade Activation of PPARGC1A (PGC-1alpha) by phosphorylation Myogenesis Signaling by VEGF Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Signalling to RAS Signalling to ERKs Organelle biogenesis and maintenance Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade VEGFA-VEGFR2 Pathway Activated TLR4 signalling Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Innate Immune System Signalling by NGF MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Mitochondrial biogenesis Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade DSCAM interactions Oxidative Stress Induced Senescence KSRP destabilizes mRNA Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways ERK/MAPK targets MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)	Chromatin organization Signaling by NOTCH Ubiquitin-dependent degradation of Cyclin D G1 Phase S Phase Cell Cycle, Mitotic RMTs methylate histone arginines Ubiquitin-dependent degradation of Cyclin D1 Cyclin D associated events in G1 Chromatin modifying enzymes Pre-NOTCH Transcription and Translation Pre-NOTCH Expression and Processing Mitotic G1-G1/S phases
Drugs			Arsenic trioxide
Diseases
GWAS			Breast cancer ( 20453838) Breast size ( 22747683) Multiple myeloma (IgH translocation) ( 23502783)
Protein-Protein Interactions		27 interactors: APP ATF2 BCL2 C9orf78 CCND1 CPNE6 DUSP10 DUSP16 EEF2K ELK1 ELK4 ESR2 HDAC3 HTRA2 JUN MAPKAPK3 MAPKAPK5 MAPT MBP NOXA1 PML POLR3D RPS6KA5 SH2D1A SOCS3 TAB1 ZNHIT1	60 interactors: AKAP8 AR ARID4A ATF2 BRCA1 BRINP1 BTRC CALM1 CAMK1 CCNDBP1 CDK4 CDK6 CDKN1A CDKN1B CDKN1C CDKN2A CRYAB CTNNB1 CUL3 DMTF1 EP300 ESR1 FBXO31 FBXO4 GSK3B HDAC3 HERC5 IFI27 INSM1 KAT2B LPL MAPK11 MCM10 MCM7 MYBL2 NCOA1 NCOA3 NPDC1 ORC4 PCNA POLR1B PRKACA RABEP1 RB1 RBL1 RBL2 RBX1 RFC1 RUNX1 SP1 STAT3 TAF1 THRA THRB TP73 TSC2 UBTF UHRF2 USP2 XPO1
Entrez ID		5600	595
HPRD ID		04208	01346
Ensembl ID		ENSG00000185386	ENSG00000110092
Uniprot IDs		L7RT27 Q15759	P24385 Q6FI00
PDB IDs		3GC8 3GC9 3GP0	2W96 2W99 2W9F 2W9Z
Enriched GO Terms of Interacting Partners?		Regulation Of Innate Immune Response Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Phosphorus Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MAPK Cascade MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Toll-like Receptor 4 Signaling Pathway Innate Immune Response Response To Stress Signal Transduction By Phosphorylation Regulation Of Immune Response Cellular Response To Stress Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Response To Organic Substance Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Immune Response Phosphorylation Signaling Cellular Response To Organic Substance Regulation Of Signal Transduction Cell Communication Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Signaling Immune System Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Protein Metabolic Process Response To Lipid Response To Growth Factor Intracellular Signal Transduction Regulation Of Growth	Cell Cycle Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process Cell Cycle Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Mitotic Cell Cycle Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Response To Organic Substance Cellular Response To Organic Substance Negative Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Chromosome Organization Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Gene Expression Mitotic Cell Cycle Process Regulation Of Protein Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Negative Regulation Of Biosynthetic Process Negative Regulation Of Protein Phosphorylation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Phosphorylation Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Cell Cycle Arrest Transcription, DNA-templated Cellular Response To Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Protein Kinase Activity RNA Biosynthetic Process G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Kinase Activity Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process
Tagcloud ?		antagonists antitumor bbc3 bcl2 ca cacna1g caco2 cdkn1a channel channels express hct116 knockdown mapkalpha occupancy p21cip1 p38 p53 p53wt promoted puma rationale rnai sb203580 ser392 stably thought	11q13 4nqo 7f4 amplicon amplification amplified cavity chr distal example fgf3 fgf4 heterozygosity hras1 inbred inconsistently involving loh murine neck nitroquinoline portion predispose scc strikingly syntenic telomeric thirds twofold
Tagcloud (Difference) ?		antagonists antitumor bbc3 bcl2 ca cacna1g caco2 cdkn1a channel channels express hct116 knockdown mapkalpha occupancy p21cip1 p38 p53 p53wt promoted puma rationale rnai sb203580 ser392 stably thought	11q13 4nqo 7f4 amplicon amplification amplified cavity chr distal example fgf3 fgf4 heterozygosity hras1 inbred inconsistently involving loh murine neck nitroquinoline portion predispose scc strikingly syntenic telomeric thirds twofold
Tagcloud (Intersection) ?