MAPK11 and DUSP10

Number of citations of the paper that reports this interaction (PMID 11359773)
28

Data Source:
HPRD (in vitro)

		MAPK11	DUSP10
Gene Name		mitogen-activated protein kinase 11	dual specificity phosphatase 10
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Phosphatase Activity
	Biological Process	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Protein Phosphorylation Response To Stress Organelle Organization Mitochondrion Organization Signal Transduction Ras Protein Signal Transduction Gene Expression Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Muscle Cell Differentiation Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade	Inactivation Of MAPK Activity Regulation Of Adaptive Immune Response Protein Dephosphorylation Response To Stress JNK Cascade Response To Lipopolysaccharide Peptidyl-tyrosine Dephosphorylation Negative Regulation Of JUN Kinase Activity Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Negative Regulation Of JNK Cascade Oligodendrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Regulation Of Brown Fat Cell Differentiation
Pathways		Cellular Senescence Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway p38MAPK events MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets activated TAK1 mediates p38 MAPK activation Regulation of mRNA stability by proteins that bind AU-rich elements CDO in myogenesis TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade Activation of PPARGC1A (PGC-1alpha) by phosphorylation Myogenesis Signaling by VEGF Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Signalling to RAS Signalling to ERKs Organelle biogenesis and maintenance Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade VEGFA-VEGFR2 Pathway Activated TLR4 signalling Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Innate Immune System Signalling by NGF MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Mitochondrial biogenesis Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade DSCAM interactions Oxidative Stress Induced Senescence KSRP destabilizes mRNA Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways ERK/MAPK targets MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS			Colorectal cancer ( 20972440)
Protein-Protein Interactions		27 interactors: APP ATF2 BCL2 C9orf78 CCND1 CPNE6 DUSP10 DUSP16 EEF2K ELK1 ELK4 ESR2 HDAC3 HTRA2 JUN MAPKAPK3 MAPKAPK5 MAPT MBP NOXA1 PML POLR3D RPS6KA5 SH2D1A SOCS3 TAB1 ZNHIT1	12 interactors: CMTM6 FHL2 FN1 HTT MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 RPS11 SLX1B SNX2
Entrez ID		5600	11221
HPRD ID		04208	12320
Ensembl ID		ENSG00000185386	ENSG00000143507
Uniprot IDs		L7RT27 Q15759	B4DDQ0 Q9Y6W6
PDB IDs		3GC8 3GC9 3GP0	1ZZW 2OUC 2OUD 3TG1
Enriched GO Terms of Interacting Partners?		Regulation Of Innate Immune Response Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Phosphorus Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MAPK Cascade MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Toll-like Receptor 4 Signaling Pathway Innate Immune Response Response To Stress Signal Transduction By Phosphorylation Regulation Of Immune Response Cellular Response To Stress Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Response To Organic Substance Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Immune Response Phosphorylation Signaling Cellular Response To Organic Substance Regulation Of Signal Transduction Cell Communication Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Signaling Immune System Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Protein Metabolic Process Response To Lipid Response To Growth Factor Intracellular Signal Transduction Regulation Of Growth	Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response MAPK Cascade Regulation Of Innate Immune Response Signal Transduction By Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Activation Of MAPK Activity Immune Response-regulating Signaling Pathway JUN Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Neurotrophin Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Immune Response Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Defense Response Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Cellular Response To Lipid Cellular Response To Stress Positive Regulation Of Catalytic Activity Positive Regulation Of Immune System Process Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Cellular Response To Lipopolysaccharide Response To Radiation Response To Stress Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Protein Kinase Activity
Tagcloud ?		antagonists antitumor bbc3 bcl2 ca cacna1g caco2 cdkn1a channel channels express hct116 knockdown mapkalpha occupancy p21cip1 p38 p53 p53wt promoted puma rationale rnai sb203580 ser392 stably thought	bc bcs dephosphorylate differentially distant dmfs dusp4 dusp6 enpp1 erbb2 erk ihc inpp4b microarray microarrays motility multiphosphatase phosphatases phosphatome phospho ppapdc1a relevance seemed series sharing signature subgroups unlike warranted
Tagcloud (Difference) ?		antagonists antitumor bbc3 bcl2 ca cacna1g caco2 cdkn1a channel channels express hct116 knockdown mapkalpha occupancy p21cip1 p38 p53 p53wt promoted puma rationale rnai sb203580 ser392 stably thought	bc bcs dephosphorylate differentially distant dmfs dusp4 dusp6 enpp1 erbb2 erk ihc inpp4b microarray microarrays motility multiphosphatase phosphatases phosphatome phospho ppapdc1a relevance seemed series sharing signature subgroups unlike warranted
Tagcloud (Intersection) ?