MAPK11 and ELK4

Number of citations of the paper that reports this interaction (PMID 9235954)
19

Data Source:
HPRD (in vitro)

		MAPK11	ELK4
Gene Name		mitogen-activated protein kinase 11	ELK4, ETS-domain protein (SRF accessory protein 1)
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol	Nucleoplasm Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Protein Phosphorylation Response To Stress Organelle Organization Mitochondrion Organization Signal Transduction Ras Protein Signal Transduction Gene Expression Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Muscle Cell Differentiation Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Differentiation Histone H3 Deacetylation
Pathways		Cellular Senescence Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway p38MAPK events MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets activated TAK1 mediates p38 MAPK activation Regulation of mRNA stability by proteins that bind AU-rich elements CDO in myogenesis TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade Activation of PPARGC1A (PGC-1alpha) by phosphorylation Myogenesis Signaling by VEGF Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Signalling to RAS Signalling to ERKs Organelle biogenesis and maintenance Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade VEGFA-VEGFR2 Pathway Activated TLR4 signalling Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Innate Immune System Signalling by NGF MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Mitochondrial biogenesis Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade DSCAM interactions Oxidative Stress Induced Senescence KSRP destabilizes mRNA Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways ERK/MAPK targets MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: APP ATF2 BCL2 C9orf78 CCND1 CPNE6 DUSP10 DUSP16 EEF2K ELK1 ELK4 ESR2 HDAC3 HTRA2 JUN MAPKAPK3 MAPKAPK5 MAPT MBP NOXA1 PML POLR3D RPS6KA5 SH2D1A SOCS3 TAB1 ZNHIT1	10 interactors: BRCA1 FOS ID1 ID2 ID3 MAPK11 MAPK3 MAPK7 MAPK8 SRF
Entrez ID		5600	2005
HPRD ID		04208	02592
Ensembl ID		ENSG00000185386	ENSG00000158711
Uniprot IDs		L7RT27 Q15759	P28324 Q8IXL1
PDB IDs		3GC8 3GC9 3GP0	1BC7 1BC8 1HBX 1K6O
Enriched GO Terms of Interacting Partners?		Regulation Of Innate Immune Response Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Phosphorus Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MAPK Cascade MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Toll-like Receptor 4 Signaling Pathway Innate Immune Response Response To Stress Signal Transduction By Phosphorylation Regulation Of Immune Response Cellular Response To Stress Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Response To Organic Substance Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Immune Response Phosphorylation Signaling Cellular Response To Organic Substance Regulation Of Signal Transduction Cell Communication Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Signaling Immune System Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Protein Metabolic Process Response To Lipid Response To Growth Factor Intracellular Signal Transduction Regulation Of Growth	Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Cellular Response To Stress MAPK Cascade Regulation Of Innate Immune Response Cellular Response To Growth Factor Stimulus Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Signal Transduction By Phosphorylation Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Response To Growth Factor Negative Regulation Of Binding Regulation Of RNA Metabolic Process Cellular Response To Organic Substance Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Response To Stress Positive Regulation Of Gene Expression Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Response To Organic Substance Immune Response-regulating Signaling Pathway Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Abiotic Stimulus Regulation Of Binding Positive Regulation Of Immune Response Negative Regulation Of Ossification Regulation Of Immune System Process Immune System Process
Tagcloud ?		antagonists antitumor bbc3 bcl2 ca cacna1g caco2 cdkn1a channel channels express hct116 knockdown mapkalpha occupancy p21cip1 p38 p53 p53wt promoted puma rationale rnai sb203580 ser392 stably thought	angiomatous cofactors ec elk1 ensured ensures exudative filopodia hallmarks hyaloid hypovascularization incomplete intraretinal macular mrtf neovascularization norrie pathologies plexi plexus protrusion reminiscent retinal srf telangiectasia tip vasculature vessels vitreoretinopathies
Tagcloud (Difference) ?		antagonists antitumor bbc3 bcl2 ca cacna1g caco2 cdkn1a channel channels express hct116 knockdown mapkalpha occupancy p21cip1 p38 p53 p53wt promoted puma rationale rnai sb203580 ser392 stably thought	angiomatous cofactors ec elk1 ensured ensures exudative filopodia hallmarks hyaloid hypovascularization incomplete intraretinal macular mrtf neovascularization norrie pathologies plexi plexus protrusion reminiscent retinal srf telangiectasia tip vasculature vessels vitreoretinopathies
Tagcloud (Intersection) ?