RNF25 and UBE2L6

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		RNF25	UBE2L6
Description		ring finger protein 25	ubiquitin conjugating enzyme E2 L6
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytosolic Ribosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding NF-kappaB Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-like Protein Transferase Activity ISG15 Transferase Activity Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Translational Elongation Translational Termination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of NF-kappaB Transcription Factor Activity Rescue Of Stalled Ribosome Protein K6-linked Ubiquitination Protein-RNA Covalent Cross-linking Repair	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process ISG15-protein Conjugation Protein Modification By Small Protein Conjugation Protein Modification Process Innate Immune Response
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes
Drugs
Diseases
GWAS		Male-pattern baldness ( 28196072)
Interacting Genes		10 interacting genes: KCTD21 MEOX2 RELA TRIM27 UBE2D1 UBE2D2 UBE2D4 UBE2E2 UBE2L6 UBE2U	44 interacting genes: ARHGDIA ARIH1 ARIH2 CBLC DTX3 FLT3 HERC5 ITCH LONRF1 MAP3K1 MID1 MUL1 NEDD4 NEDD4L PJA2 PRKN RBCK1 RBX1 RNF122 RNF144A RNF144B RNF150 RNF19A RNF216 RNF25 RNF4 RNF40 RUNX1 SIAH1 SIAH2 SPEN TOPORS TRAF7 TRIM13 TRIM25 TRIM27 TRIM28 TRIM62 TRIM8 UBA1 UBA6 UBA7 UBE3A YAP1
Entrez ID		64320	9246
HPRD ID		09737	04867
Ensembl ID		ENSG00000163481	ENSG00000156587
Uniprot IDs		Q96BH1	O14933
PDB IDs		2DAY 2DMF 5D1K 5D1L 5D1M	1WZV 1WZW 2KJH 8OIF 8SE9 8SEA 8SEB 8SV8
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Metabolic Process Modification-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Modification Process Transferase Activity Proteolysis Involved In Protein Catabolic Process ISG15 Transferase Activity ISG15-protein Conjugation Protein K63-linked Ubiquitination Macromolecule Metabolic Process Proteolysis Catabolic Process Ubiquitin-like Protein Transferase Activity Protein K11-linked Ubiquitination ATP Binding NF-kappaB P50/p65 Complex Ubiquitin Protein Ligase Activity Positive Regulation Of Schwann Cell Differentiation Response To Cobalamin N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Schwann Cell Differentiation NF-kappaB Complex Prolactin Signaling Pathway Nucleotide Binding Somite Specification Postsynapse To Nucleus Signaling Pathway Histone Deacetylase Binding Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity HULC Complex	Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification Process Macromolecule Catabolic Process Transferase Activity Proteolysis Protein Metabolic Process Protein Polyubiquitination Zinc Ion Binding Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Macromolecule Metabolic Process Protein Catabolic Process Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Protein Monoubiquitination Suppression Of Viral Release By Host Protein K63-linked Ubiquitination Protein Autoubiquitination Transcription Coactivator Activity Innate Immune Response Negative Regulation Of Viral Transcription Positive Regulation Of Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Viral Transcription SUMO Transferase Activity Cytoplasm Defense Response To Symbiont Defense Response To Other Organism Protein K6-linked Ubiquitination Defense Response To Virus Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Negative Regulation Of Viral Process Regulation Of Viral Process Ubiquitin-like Modifier Activating Enzyme Activity Response To Other Organism Protein K29-linked Ubiquitination Positive Regulation Of Cell Communication
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