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RNF25 and UBE2E2
Number of citations of the paper that reports this interaction (PMID
19549727
)
40
Data Source:
BioGRID
(two hybrid)
RNF25
UBE2E2
Gene Name
ring finger protein 25
ubiquitin-conjugating enzyme E2E 2
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Cytosol
Molecular Function
Ubiquitin-protein Transferase Activity
Zinc Ion Binding
Ligase Activity
NF-kappaB Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ligase Activity
ISG15 Transferase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
Protein Ubiquitination
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cellular Response To DNA Damage Stimulus
ISG15-protein Conjugation
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
11 interactors:
RELA
TRIM27
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2L6
UBE2U
61 interactors:
APP
ARIH1
ARIH2
ARRDC3
BARD1
BRCA1
CHFR
CUL3
CUL9
DAZAP2
DTX3
DTX3L
DZIP3
FAM9B
FHL1
IPO11
ISG15
MARCH3
MDM2
MID1
MID2
MKRN3
MUL1
NFE2L2
PCGF2
PRAM1
RING1
RLIM
RNF10
RNF103
RNF11
RNF111
RNF114
RNF125
RNF14
RNF166
RNF185
RNF19A
RNF2
RNF25
RNF4
RNF5
RNF8
SRPK1
SRPK2
STUB1
TRIM2
TRIM23
TRIM27
TRIM28
TRIM31
TRIM32
TRIM37
TRIM38
TRIM39
TRIM45
TRIM50
UBA1
UBOX5
XIAP
ZNRF1
Entrez ID
64320
7325
HPRD ID
09737
06779
Ensembl ID
ENSG00000163481
Uniprot IDs
Q96BH1
Q96LR5
PDB IDs
2DAY
2DMF
1Y6L
Enriched GO Terms of Interacting Partners
?
Protein Polyubiquitination
Protein K48-linked Ubiquitination
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Protein K11-linked Ubiquitination
Protein K63-linked Ubiquitination
ISG15-protein Conjugation
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Cellular Protein Modification Process
Toll-like Receptor 4 Signaling Pathway
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Protein Metabolic Process
Toll-like Receptor Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Cellular Protein Metabolic Process
Innate Immune Response
Cellular Macromolecule Catabolic Process
Positive Regulation Of Innate Immune Response
Proteolysis
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Ubiquitin-dependent Protein Catabolic Process
Regulation Of DNA-templated Transcription In Response To Stress
Regulation Of Innate Immune Response
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Immune Response
Defense Response
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Regulation Of Type I Interferon Production
Cellular Response To Oxygen Levels
Negative Regulation Of Protein Catabolic Process
Response To Stress
Cellular Response To Stress
Regulation Of Immune Response
Immune Response-regulating Signaling Pathway
Catabolic Process
Regulation Of Cytokine Production
Cellular Metabolic Process
Negative Regulation Of Cytokine Production
Mitotic Spindle Assembly Checkpoint
Histone Ubiquitination
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Cellular Protein Modification Process
Cellular Protein Metabolic Process
Protein Metabolic Process
Protein Polyubiquitination
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Cellular Metabolic Process
Negative Regulation Of Viral Process
Protein Autoubiquitination
Catabolic Process
Regulation Of Viral Process
Proteolysis
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Regulation Of Viral Release From Host Cell
Metabolic Process
Histone Ubiquitination
Negative Regulation Of Cellular Metabolic Process
Histone H2A Ubiquitination
Innate Immune Response
Negative Regulation Of Viral Release From Host Cell
Protein Monoubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Histone Monoubiquitination
Proteasomal Protein Catabolic Process
Negative Regulation Of Viral Transcription
Response To Stress
Regulation Of Protein Ubiquitination
Protein K6-linked Ubiquitination
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Immune Response
Regulation Of Cell Cycle
Negative Regulation Of Gene Expression
Negative Regulation Of RNA Biosynthetic Process
Histone H2A Monoubiquitination
Histone H2A-K119 Monoubiquitination
Cellular Response To Stress
Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Defense Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Gene Expression
Tagcloud
?
3p24
amino
assigned
bond
cdna
conjugating
drosophila
e1
encoding
enzyme
extension
fluorescence
formed
hybridization
identity
kb
product
shares
similarity
thioester
transcribed
transcript
ubc
ubcd2
ubch6
ubch8
ubcm2
ubiquitin
Tagcloud (Difference)
?
3p24
amino
assigned
bond
cdna
conjugating
drosophila
e1
encoding
enzyme
extension
fluorescence
formed
hybridization
identity
kb
product
shares
similarity
thioester
transcribed
transcript
ubc
ubcd2
ubch6
ubch8
ubcm2
ubiquitin
Tagcloud (Intersection)
?