NOG and BMP4

Number of citations of the paper that reports this interaction (PMID 11706034)
28

Data Source:
HPRD (in vivo)

		NOG	BMP4
Gene Name		noggin	bone morphogenetic protein 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space
	Molecular Function	Protein Binding Cytokine Binding Protein Homodimerization Activity	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity BMP Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Osteoblast Differentiation In Utero Embryonic Development Endoderm Formation Mesoderm Formation Epithelial To Mesenchymal Transition Neural Plate Morphogenesis Neural Tube Closure Nervous System Development Motor Neuron Axon Guidance Dorsal/ventral Pattern Formation Spinal Cord Development Cell Differentiation In Hindbrain Pituitary Gland Development Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Somatic Stem Cell Maintenance Wound Healing Middle Ear Morphogenesis Embryonic Digit Morphogenesis Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Axial Mesoderm Development Notochord Morphogenesis Embryonic Skeletal System Development Negative Regulation Of Astrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Negative Regulation Of Cardiac Muscle Cell Proliferation Limb Development Embryonic Skeletal Joint Morphogenesis Negative Regulation Of Cytokine Activity Face Morphogenesis Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Lung Morphogenesis Prostatic Bud Formation Ureteric Bud Formation Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Negative Regulation Of Cartilage Development Somite Development Cellular Response To BMP Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Glomerulus Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Negative Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPKK Activity Osteoblast Differentiation Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Mesonephros Development Neural Tube Closure Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Chondrocyte Differentiation Hematopoietic Progenitor Cell Differentiation Lymphoid Progenitor Cell Differentiation Renal System Process BMP Signaling Pathway Involved In Heart Induction Secondary Heart Field Specification Endocardial Cushion Development Cardiac Septum Development Type B Pancreatic Cell Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Common-partner SMAD Protein Phosphorylation Smoothened Signaling Pathway Germ Cell Development Mesodermal Cell Fate Determination Negative Regulation Of Cell Proliferation Post-embryonic Development Anterior/posterior Axis Specification Specification Of Organ Position Regulation Of Cell Fate Commitment Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Cell Death Telencephalon Development Dorsal/ventral Neural Tube Patterning Telencephalon Regionalization Pituitary Gland Development Extracellular Matrix Organization Erythrocyte Differentiation Monocyte Differentiation Macrophage Differentiation Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Binding Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Protein Localization To Nucleus Embryonic Hindlimb Morphogenesis Tendon Cell Differentiation Deltoid Tuberosity Development Regulation Of Protein Import Into Nucleus Negative Regulation Of Phosphorylation Odontogenesis Of Dentin-containing Tooth Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Negative Regulation Of MAP Kinase Activity Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Lung Alveolus Development Intermediate Mesodermal Cell Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Embryonic Cranial Skeleton Morphogenesis Smooth Muscle Tissue Development Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Positive Chemotaxis Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Fiber Development Inner Ear Receptor Cell Differentiation Cloacal Septation Lens Induction In Camera-type Eye Embryonic Skeletal Joint Morphogenesis Cranial Suture Morphogenesis Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Lung Morphogenesis Bronchus Development Trachea Development Trachea Formation Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Prostate Gland Morphogenesis Bud Elongation Involved In Lung Branching Epithelial Cell Proliferation Involved In Lung Morphogenesis Bud Dilation Involved In Lung Branching Negative Regulation Of Cell Death Mammary Gland Formation Epithelial-mesenchymal Cell Signaling Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Positive Regulation Of Cartilage Development Positive Regulation Of Branching Involved In Lung Morphogenesis BMP Signaling Pathway Involved In Ureter Morphogenesis BMP Signaling Pathway Involved In Renal System Segmentation Pulmonary Artery Endothelial Tube Morphogenesis Negative Regulation Of Thymocyte Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus BMP Signaling Pathway Involved In Nephric Duct Formation Renal System Development Glomerular Visceral Epithelial Cell Development Negative Regulation Of Branch Elongation Involved In Ureteric Bud Branching By BMP Signaling Pathway Specification Of Ureteric Bud Anterior/posterior Symmetry By BMP Signaling Pathway Glomerular Capillary Formation Negative Regulation Of Glomerular Mesangial Cell Proliferation Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Mesenchymal Cell Differentiation Involved In Kidney Development Ureter Epithelial Cell Differentiation Ureter Smooth Muscle Cell Differentiation Mesenchymal Cell Proliferation Involved In Ureter Development Negative Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Metanephric Collecting Duct Development Positive Regulation Of Kidney Development Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Glomerulus Development Negative Regulation Of Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Comma-shaped Body Morphogenesis Positive Regulation Of DNA-dependent DNA Replication Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Pathways		Signaling by BMP	Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS		Height ( 20881960 18391951) Orofacial clefts ( 20023658)	Colorectal cancer ( 19011631) Dental caries ( 23259602) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Parkinson's disease ( 19915575) Primary tooth development (time to first tooth eruption) ( 23704328)
Protein-Protein Interactions		4 interactors: BMP2 BMP4 BMP5 BMP7	15 interactors: BGN BMP8B BMPER BMPR1A BMPR1B BMPR2 CHRDL1 CHRDL2 GREM2 HTRA1 NOG SOSTDC1 STAP2 TWSG1 ZFYVE9
Entrez ID		9241	652
HPRD ID		04291	00207
Ensembl ID		ENSG00000183691	ENSG00000125378
Uniprot IDs		Q13253	P12644 Q53XC5
PDB IDs		1M4U
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction BMP Signaling Pathway Cell Proliferation Involved In Kidney Development Mesenchymal Cell Proliferation Cartilage Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Positive Regulation Of Bone Mineralization Ossification Positive Regulation Of Biomineral Tissue Development Glandular Epithelial Cell Differentiation Regulation Of Organ Formation Positive Regulation Of Neuron Differentiation Negative Regulation Of Glomerular Mesangial Cell Proliferation Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Negative Regulation Of Glomerulus Development BMP Signaling Pathway Involved In Heart Induction Positive Regulation Of Neurogenesis Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Aldosterone Biosynthetic Process Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Pattern Specification Process BMP Signaling Pathway Involved In Heart Development Negative Regulation Of Cell Proliferation Involved In Kidney Development Growth Stem Cell Proliferation Positive Regulation Of Cell Development Epithelial Cell Differentiation Positive Regulation Of Ossification Regulation Of Neuron Differentiation Skeletal System Development Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Glucocorticoid Biosynthetic Process Regulation Of Glomerular Mesangial Cell Proliferation Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Regulation Of MAPK Cascade Mesonephros Development Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Proliferation Odontogenesis Mesenchymal Cell Differentiation Negative Regulation Of Steroid Hormone Biosynthetic Process	Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Cartilage Development Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Connective Tissue Development Regulation Of Osteoblast Differentiation Organ Development Regulation Of Ossification Tissue Development Pattern Specification Process Mesoderm Formation Mesoderm Morphogenesis Multicellular Organismal Development Negative Regulation Of Chondrocyte Proliferation Anatomical Structure Development Skeletal System Development Ossification Sensory Organ Development Organ Morphogenesis Dorsal/ventral Pattern Formation Formation Of Primary Germ Layer Regulation Of Cytokine Activity Cell Surface Receptor Signaling Pathway System Development Mesoderm Development Developmental Process Anatomical Structure Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Gastrulation Proteoglycan Biosynthetic Process Limb Development Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Regulation Of Epithelial Cell Proliferation Embryonic Morphogenesis Tissue Morphogenesis Cell Differentiation
Tagcloud ?		activate grb2 gtp hormone jak2 kda leading malignant mammary mapk min mitogenesis observe peak prl prolactin proliferating rapid ras reached regulates responsive shc sos stat5 t47d transduction transient within	agonists antagonists apoptosis bmp2 causes complete controlling directly embryonal example exert identification induce malignant members p19 prevents ra regulate requires retinoic retinoid retinoids specifically sufficient synergize transforming variety
Tagcloud (Difference) ?		activate grb2 gtp hormone jak2 kda leading mammary mapk min mitogenesis observe peak prl prolactin proliferating rapid ras reached regulates responsive shc sos stat5 t47d transduction transient within	agonists antagonists apoptosis bmp2 causes complete controlling directly embryonal example exert identification induce members p19 prevents ra regulate requires retinoic retinoid retinoids specifically sufficient synergize transforming variety
Tagcloud (Intersection) ?		malignant