NOG and BMP7

Number of citations of the paper that reports this interaction (PMID 12478285)
73

Data Source:
HPRD (in vitro)

		NOG	BMP7
Gene Name		noggin	bone morphogenetic protein 7
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Extracellular Matrix Membrane-bounded Vesicle
	Molecular Function	Protein Binding Cytokine Binding Protein Homodimerization Activity	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Heparin Binding BMP Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Osteoblast Differentiation In Utero Embryonic Development Endoderm Formation Mesoderm Formation Epithelial To Mesenchymal Transition Neural Plate Morphogenesis Neural Tube Closure Nervous System Development Motor Neuron Axon Guidance Dorsal/ventral Pattern Formation Spinal Cord Development Cell Differentiation In Hindbrain Pituitary Gland Development Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Somatic Stem Cell Maintenance Wound Healing Middle Ear Morphogenesis Embryonic Digit Morphogenesis Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Axial Mesoderm Development Notochord Morphogenesis Embryonic Skeletal System Development Negative Regulation Of Astrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Negative Regulation Of Cardiac Muscle Cell Proliferation Limb Development Embryonic Skeletal Joint Morphogenesis Negative Regulation Of Cytokine Activity Face Morphogenesis Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Lung Morphogenesis Prostatic Bud Formation Ureteric Bud Formation Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Negative Regulation Of Cartilage Development Somite Development Cellular Response To BMP Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Glomerulus Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Negative Regulation Of Apoptotic Signaling Pathway	Skeletal System Development Ossification Metanephros Development Ureteric Bud Development Mesoderm Formation Mesonephros Development Epithelial To Mesenchymal Transition Axon Guidance Embryonic Pattern Specification Negative Regulation Of Striated Muscle Cell Apoptotic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Dendrite Development Extracellular Matrix Organization Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization BMP Signaling Pathway Epithelial Cell Differentiation Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Estradiol Response To Vitamin D Positive Regulation Of Heterotypic Cell-cell Adhesion Protein Localization To Nucleus Growth Negative Regulation Of Phosphorylation Negative Regulation Of NF-kappaB Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Negative Regulation Of MAP Kinase Activity Response To Peptide Hormone Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Camera-type Eye Morphogenesis Branching Morphogenesis Of An Epithelial Tube Mesenchymal Cell Differentiation Neuron Projection Morphogenesis Cartilage Development Embryonic Skeletal Joint Morphogenesis Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Branching Involved In Salivary Gland Morphogenesis Mesenchyme Development Negative Regulation Of Cell Death Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Monocyte Aggregation Cellular Response To Hypoxia Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Negative Regulation Of Glomerular Mesangial Cell Proliferation Metanephric Mesenchyme Morphogenesis Nephrogenic Mesenchyme Morphogenesis Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Positive Regulation Of Dendrite Development Positive Regulation Of Hyaluranon Cable Assembly Regulation Of Removal Of Superoxide Radicals
Pathways		Signaling by BMP	Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS		Height ( 20881960 18391951) Orofacial clefts ( 20023658)	Response to citalopram treatment ( 19846067) White blood cell types ( 21738478)
Protein-Protein Interactions		4 interactors: BMP2 BMP4 BMP5 BMP7	21 interactors: ACTN4 ACVR1 ACVR2A ACVR2B BMPR1A BMPR1B BMPR2 CHRDL2 ENG GDF7 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP5-9 MTUS2 NCOA3 NOG NOTCH2NL SOSTDC1 TRIM27
Entrez ID		9241	655
HPRD ID		04291	00212
Ensembl ID		ENSG00000183691	ENSG00000101144
Uniprot IDs		Q13253	A8K571 P18075
PDB IDs		1M4U	1BMP 1LX5 1LXI 1M4U
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction BMP Signaling Pathway Cell Proliferation Involved In Kidney Development Mesenchymal Cell Proliferation Cartilage Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Positive Regulation Of Bone Mineralization Ossification Positive Regulation Of Biomineral Tissue Development Glandular Epithelial Cell Differentiation Regulation Of Organ Formation Positive Regulation Of Neuron Differentiation Negative Regulation Of Glomerular Mesangial Cell Proliferation Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Negative Regulation Of Glomerulus Development BMP Signaling Pathway Involved In Heart Induction Positive Regulation Of Neurogenesis Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Aldosterone Biosynthetic Process Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Pattern Specification Process BMP Signaling Pathway Involved In Heart Development Negative Regulation Of Cell Proliferation Involved In Kidney Development Growth Stem Cell Proliferation Positive Regulation Of Cell Development Epithelial Cell Differentiation Positive Regulation Of Ossification Regulation Of Neuron Differentiation Skeletal System Development Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Glucocorticoid Biosynthetic Process Regulation Of Glomerular Mesangial Cell Proliferation Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Regulation Of MAPK Cascade Mesonephros Development Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Proliferation Odontogenesis Mesenchymal Cell Differentiation Negative Regulation Of Steroid Hormone Biosynthetic Process	BMP Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Tissue Development Regulation Of Osteoblast Differentiation Pattern Specification Process Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Activin Receptor Signaling Pathway Regulation Of BMP Signaling Pathway Regulation Of Ossification Positive Regulation Of Ossification Embryonic Morphogenesis Organ Morphogenesis Tube Development Epithelium Development Mesoderm Development Skeletal System Development Enzyme Linked Receptor Protein Signaling Pathway Gastrulation Regulation Of Transcription From RNA Polymerase II Promoter Tissue Morphogenesis Tube Morphogenesis Regulation Of Protein Phosphorylation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Differentiation Embryo Development Signal Transduction By Phosphorylation Organ Development Regulation Of Signaling Positive Regulation Of Cell Differentiation Anatomical Structure Morphogenesis Regulation Of Phosphorylation Protein Phosphorylation Signal Transduction Developmental Process Regulation Of Phosphorus Metabolic Process Epithelial Tube Morphogenesis Signaling Cartilage Development Venous Blood Vessel Development Cell Communication Endothelial Cell Differentiation Developmental Process Involved In Reproduction Positive Regulation Of Protein Phosphorylation Multicellular Organismal Development
Tagcloud ?		activate grb2 gtp hormone jak2 kda leading malignant mammary mapk min mitogenesis observe peak prl prolactin proliferating rapid ras reached regulates responsive shc sos stat5 t47d transduction transient within	antisecretory belonging cd133 celebrex concomittant downregulated esomeprasol favourably feed heterodimer imply indomethacin list master microarrays micrornas niche nsaid nsaids oct4 oncomirs peroperative preservation prominin1 served sox2 stemness suppressors switchoff
Tagcloud (Difference) ?		activate grb2 gtp hormone jak2 kda leading malignant mammary mapk min mitogenesis observe peak prl prolactin proliferating rapid ras reached regulates responsive shc sos stat5 t47d transduction transient within	antisecretory belonging cd133 celebrex concomittant downregulated esomeprasol favourably feed heterodimer imply indomethacin list master microarrays micrornas niche nsaid nsaids oct4 oncomirs peroperative preservation prominin1 served sox2 stemness suppressors switchoff
Tagcloud (Intersection) ?