NOG and BMP5

Number of citations of the paper that reports this interaction (PMID 11580864)
12

Data Source:
HPRD (in vivo)

		NOG	BMP5
Gene Name		noggin	bone morphogenetic protein 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Cellular_component Extracellular Space Membrane-bounded Vesicle
	Molecular Function	Protein Binding Cytokine Binding Protein Homodimerization Activity	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Growth Factor Activity BMP Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Osteoblast Differentiation In Utero Embryonic Development Endoderm Formation Mesoderm Formation Epithelial To Mesenchymal Transition Neural Plate Morphogenesis Neural Tube Closure Nervous System Development Motor Neuron Axon Guidance Dorsal/ventral Pattern Formation Spinal Cord Development Cell Differentiation In Hindbrain Pituitary Gland Development Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Somatic Stem Cell Maintenance Wound Healing Middle Ear Morphogenesis Embryonic Digit Morphogenesis Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Axial Mesoderm Development Notochord Morphogenesis Embryonic Skeletal System Development Negative Regulation Of Astrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Negative Regulation Of Cardiac Muscle Cell Proliferation Limb Development Embryonic Skeletal Joint Morphogenesis Negative Regulation Of Cytokine Activity Face Morphogenesis Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Lung Morphogenesis Prostatic Bud Formation Ureteric Bud Formation Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Negative Regulation Of Cartilage Development Somite Development Cellular Response To BMP Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Glomerulus Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Negative Regulation Of Apoptotic Signaling Pathway	Skeletal System Development Ossification Type B Pancreatic Cell Development Pattern Specification Process Negative Regulation Of Cell Proliferation Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Steroid Biosynthetic Process BMP Signaling Pathway Male Genitalia Development Negative Regulation Of Aldosterone Biosynthetic Process Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Epithelial Cell Proliferation Cartilage Development SMAD Protein Signal Transduction Negative Regulation Of Mononuclear Cell Migration Positive Regulation Of Dendrite Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cortisol Biosynthetic Process Positive Regulation Of DNA-dependent DNA Replication
Pathways		Signaling by BMP
Drugs
Diseases
GWAS		Height ( 20881960 18391951) Orofacial clefts ( 20023658)
Protein-Protein Interactions		4 interactors: BMP2 BMP4 BMP5 BMP7	4 interactors: BMPR1A CHRDL2 FST NOG
Entrez ID		9241	653
HPRD ID		04291	00210
Ensembl ID		ENSG00000183691	ENSG00000112175
Uniprot IDs		Q13253	B4E0Y4 M9VUD0 P22003
PDB IDs		1M4U
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction BMP Signaling Pathway Cell Proliferation Involved In Kidney Development Mesenchymal Cell Proliferation Cartilage Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Positive Regulation Of Bone Mineralization Ossification Positive Regulation Of Biomineral Tissue Development Glandular Epithelial Cell Differentiation Regulation Of Organ Formation Positive Regulation Of Neuron Differentiation Negative Regulation Of Glomerular Mesangial Cell Proliferation Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Negative Regulation Of Glomerulus Development BMP Signaling Pathway Involved In Heart Induction Positive Regulation Of Neurogenesis Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Aldosterone Biosynthetic Process Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Pattern Specification Process BMP Signaling Pathway Involved In Heart Development Negative Regulation Of Cell Proliferation Involved In Kidney Development Growth Stem Cell Proliferation Positive Regulation Of Cell Development Epithelial Cell Differentiation Positive Regulation Of Ossification Regulation Of Neuron Differentiation Skeletal System Development Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Glucocorticoid Biosynthetic Process Regulation Of Glomerular Mesangial Cell Proliferation Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Regulation Of MAPK Cascade Mesonephros Development Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Proliferation Odontogenesis Mesenchymal Cell Differentiation Negative Regulation Of Steroid Hormone Biosynthetic Process	BMP Signaling Pathway Skeletal System Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cartilage Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Negative Regulation Of BMP Signaling Pathway Organ Formation Tissue Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation Pituitary Gland Development Pattern Specification Process Embryonic Digit Morphogenesis Regulation Of BMP Signaling Pathway Endoderm Development Mesoderm Formation Tissue Morphogenesis Diencephalon Development Mesoderm Morphogenesis Somite Development Developmental Process Involved In Reproduction Negative Regulation Of Cell Differentiation Odontogenesis Of Dentin-containing Tooth Mesenchymal Cell Development Dorsal/ventral Pattern Formation Neural Plate Mediolateral Regionalization Negative Regulation Of Cytokine Activity Paraxial Mesoderm Structural Organization Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Regulation Of Osteoblast Differentiation Formation Of Primary Germ Layer Odontogenesis Regulation Of Signal Transduction Mesenchymal Cell Differentiation Enzyme Linked Receptor Protein Signaling Pathway Mesoderm Development Stem Cell Maintenance Positive Regulation Of Epithelial Cell Proliferation Organ Development Embryonic Limb Morphogenesis Organ Morphogenesis Regulation Of Signaling Limb Morphogenesis Regulation Of Organ Morphogenesis Epithelium Development Negative Regulation Of Signal Transduction Gastrulation Regulation Of Ossification Limb Development Mesenchyme Development
Tagcloud ?		activate grb2 gtp hormone jak2 kda leading malignant mammary mapk min mitogenesis observe peak prl prolactin proliferating rapid ras reached regulates responsive shc sos stat5 t47d transduction transient within	abundant adenomatosis apcdd1 bmpr1a closure destinies dictated dkk2 e15 edge eyelid eyelids fetuses fgfr2 gli2 identities ie jag1 lcm le microdissection morphogenetic notch1 opening polyposis ptch1 shh smo tip
Tagcloud (Difference) ?		activate grb2 gtp hormone jak2 kda leading malignant mammary mapk min mitogenesis observe peak prl prolactin proliferating rapid ras reached regulates responsive shc sos stat5 t47d transduction transient within	abundant adenomatosis apcdd1 bmpr1a closure destinies dictated dkk2 e15 edge eyelid eyelids fetuses fgfr2 gli2 identities ie jag1 lcm le microdissection morphogenetic notch1 opening polyposis ptch1 shh smo tip
Tagcloud (Intersection) ?