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NOG
Gene Name
noggin
Image
Gene Ontology Annotations
Cellular Component
Extracellular Region
Extracellular Space
Molecular Function
Protein Binding
Cytokine Binding
Protein Homodimerization Activity
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Skeletal System Development
Osteoblast Differentiation
In Utero Embryonic Development
Endoderm Formation
Mesoderm Formation
Epithelial To Mesenchymal Transition
Neural Plate Morphogenesis
Neural Tube Closure
Nervous System Development
Motor Neuron Axon Guidance
Dorsal/ventral Pattern Formation
Spinal Cord Development
Cell Differentiation In Hindbrain
Pituitary Gland Development
Negative Regulation Of Cell Migration
BMP Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Somatic Stem Cell Maintenance
Wound Healing
Middle Ear Morphogenesis
Embryonic Digit Morphogenesis
Negative Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Axial Mesoderm Development
Notochord Morphogenesis
Embryonic Skeletal System Development
Negative Regulation Of Astrocyte Differentiation
Positive Regulation Of Epithelial Cell Proliferation
Cartilage Development
Negative Regulation Of Cardiac Muscle Cell Proliferation
Limb Development
Embryonic Skeletal Joint Morphogenesis
Negative Regulation Of Cytokine Activity
Face Morphogenesis
Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Lung Morphogenesis
Prostatic Bud Formation
Ureteric Bud Formation
Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation
Negative Regulation Of Cartilage Development
Somite Development
Cellular Response To BMP Stimulus
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Positive Regulation Of Glomerulus Development
Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation
Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Signaling by BMP
Drugs
Diseases
GWAS
Height (
20881960
18391951
)
Orofacial clefts (
20023658
)
Protein-protein Interactions
4 interactors:
BMP2
BMP4
BMP5
BMP7
Entrez ID
9241
HPRD ID
04291
Ensembl ID
ENSG00000183691
Uniprot IDs
Q13253
PDB IDs
1M4U
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Regulation Of Pathway-restricted SMAD Protein Phosphorylation
SMAD Protein Signal Transduction
BMP Signaling Pathway
Cell Proliferation Involved In Kidney Development
Mesenchymal Cell Proliferation
Cartilage Development
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Connective Tissue Development
Positive Regulation Of Bone Mineralization
Ossification
Positive Regulation Of Biomineral Tissue Development
Glandular Epithelial Cell Differentiation
Regulation Of Organ Formation
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Glomerular Mesangial Cell Proliferation
Mesenchymal Cell Proliferation Involved In Ureteric Bud Development
Negative Regulation Of Glomerulus Development
BMP Signaling Pathway Involved In Heart Induction
Positive Regulation Of Neurogenesis
Negative Regulation Of Cortisol Biosynthetic Process
Negative Regulation Of Aldosterone Biosynthetic Process
Regulation Of Bone Mineralization
Positive Regulation Of Osteoblast Differentiation
Pattern Specification Process
BMP Signaling Pathway Involved In Heart Development
Negative Regulation Of Cell Proliferation Involved In Kidney Development
Growth
Stem Cell Proliferation
Positive Regulation Of Cell Development
Epithelial Cell Differentiation
Positive Regulation Of Ossification
Regulation Of Neuron Differentiation
Skeletal System Development
Odontogenesis Of Dentin-containing Tooth
Negative Regulation Of Glucocorticoid Biosynthetic Process
Regulation Of Glomerular Mesangial Cell Proliferation
Ureteric Bud Development
Mesonephric Tubule Development
Mesonephric Epithelium Development
Regulation Of MAPK Cascade
Mesonephros Development
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Negative Regulation Of Prostatic Bud Formation
Regulation Of Branching Involved In Prostate Gland Morphogenesis
Regulation Of Osteoblast Differentiation
Negative Regulation Of Cell Proliferation
Odontogenesis
Mesenchymal Cell Differentiation
Negative Regulation Of Steroid Hormone Biosynthetic Process
Tagcloud
?
activate
grb2
gtp
hormone
jak2
kda
leading
malignant
mammary
mapk
min
mitogenesis
observe
peak
prl
prolactin
proliferating
rapid
ras
reached
regulates
responsive
shc
sos
stat5
t47d
transduction
transient
within