UBTD2 and UBA1

Number of citations of the paper that reports this interaction (PubMedID 25207809)
50

Data Source:
BioGRID (pull down)

		UBTD2	UBA1
Description		ubiquitin domain containing 2	ubiquitin like modifier activating enzyme 1
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GO Annotations	Cellular Component	Cytoplasm	Heterochromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Endosome Membrane Desmosome Rough Endoplasmic Reticulum Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Nucleotide Binding RNA Binding Ubiquitin Activating Enzyme Activity Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity
	Biological Process		Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Hexatantalum Dodecabromide Quercetin
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS
Interacting Genes		14 interacting genes: AQP6 ARID5A GPS2 INCA1 KLHL35 MRPL17 MVP RNF4 TRIB3 TRIM39 UBA1 UBE2D4 USP5 YPEL3	51 interacting genes: ABCF1 AZGP1P2 BUB3 CDK1 CEBPA CHEK1 ECHS1 GAN GRB2 HGS HSPH1 LINC01554 MGMT MTNR1A OGT PIAS3 SEMA3F SMAD5 SUMO2 TAF9 TMCC2 TSSC4 TTC19 UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2J1 UBE2J2 UBE2K UBE2L1 UBE2L3 UBE2L6 UBE2M UBE2N UBE2Q2 UBE2R2 UBE2S UBE2T UBE2U UBE2W UBE2Z UBTD2
Entrez ID		92181	7317
HPRD ID		13118	02440
Ensembl ID		ENSG00000168246	ENSG00000130985
Uniprot IDs		B3KMW8 Q8WUN7	A0A024R1A3 P22314
PDB IDs		1TTN 2KSN	4P22 6DC6 7PYV
Enriched GO Terms of Interacting Partners?		Nitrate Transmembrane Transporter Activity Negative Regulation Of Fat Cell Differentiation Transcription Corepressor Activity Cyclin Binding Negative Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Protein K6-linked Ubiquitination Post-translational Protein Modification Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Kinase Activity Protein Kinase Inhibitor Activity Regulation Of Kinase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Regulation Of Protein Modification Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Proteolysis Negative Regulation Of Kinase Activity Negative Regulation Of Protein Kinase Activity Nucleus Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Kinetochore Assembly Ubiquitin Activating Enzyme Activity Regulation Protein Catabolic Process At Presynapse Negative Regulation Of Metabolic Process Protein K48-linked Ubiquitination Regulation Of T Cell Mediated Immunity Regulation Of Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Autophosphorylation Regulation Of Protein Phosphorylation Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Negative Regulation Of Protein K63-linked Ubiquitination	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein K48-linked Ubiquitination Ubiquitin-like Protein Transferase Activity Protein Modification Process Protein K11-linked Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process ATP Binding Transferase Activity Ubiquitin-dependent Protein Catabolic Process Nucleotide Binding Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Ubiquitin Protein Ligase Binding Protein Monoubiquitination Macromolecule Metabolic Process Catabolic Process Protein K63-linked Ubiquitination Proteasomal Protein Catabolic Process Protein K6-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Nucleoplasm ISG15 Transferase Activity HULC Complex DNA Damage Response ISG15-protein Conjugation Regulation Of Post-translational Protein Modification Free Ubiquitin Chain Polymerization Nucleus DNA Repair Positive Regulation Of Post-translational Protein Modification Protein K29-linked Ubiquitination Cellular Response To Stress Cell Cycle Phase Transition Ubiquitin Binding Regulation Of Protein Modification Process Protein K27-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Positive Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination TORC1 Signaling DNA Metabolic Process
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