UBTD2 and USP5

Number of citations of the paper that reports this interaction (PMID 25207809)
0

Data Source:
BioGRID (pull down, affinity chromatography technology)

		UBTD2	USP5
Gene Name		ubiquitin domain containing 2	ubiquitin specific peptidase 5 (isopeptidase T)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Lysosome
	Molecular Function		Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Omega Peptidase Activity Zinc Ion Binding
	Biological Process		Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: TRIM39 UBA1 USP5	22 interactors: APP DAZAP2 DVL2 PJA1 PLA2G2A RFFL RNF11 STK33 TADA3 TMEM239 TRAF6 TRIM26 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIML1 UBC UBE2S UBTD2 USP28
Entrez ID		92181	8078
HPRD ID		13118	03265
Ensembl ID		ENSG00000168246	ENSG00000111667
Uniprot IDs		B2R886 B3KMW8 Q8WUN7	P45974
PDB IDs		1TTN 2KSN	2DAG 2DAK 2G43 2G45 3IHP
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Protein K48-linked Deubiquitination Regulation Of Proteolysis Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteolysis Negative Regulation Of Protein Ubiquitination Protein Metabolic Process Protein Deubiquitination Negative Regulation Of Protein Catabolic Process Protein Modification By Small Protein Removal Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein K63-linked Ubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Catabolic Process Cellular Macromolecule Catabolic Process Negative Regulation Of Viral Release From Host Cell Apoptotic Process Negative Regulation Of Viral Entry Into Host Cell Programmed Cell Death Proteolysis Cell Death Regulation Of Lipopolysaccharide-mediated Signaling Pathway Death Regulation Of Viral Entry Into Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteolysis Regulation Of Viral Release From Host Cell Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Response To Cytokine Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Activation Of Innate Immune Response Cellular Metabolic Process Innate Immune Response Positive Regulation Of MAPK Cascade Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Phosphorylation Cytokine-mediated Signaling Pathway Positive Regulation Of Innate Immune Response Defense Response Protein Autoubiquitination
Tagcloud ?			acquired add already alternate alters braf checkpoint damaging deubiquitinase dub eoai3402143 fas intrinsically knockdown mek melanoma modulating nras overcame p73 phenocopied restored sensitization sensitized strand suppress ub unanchored vemurafenib
Tagcloud (Difference) ?			acquired add already alternate alters braf checkpoint damaging deubiquitinase dub eoai3402143 fas intrinsically knockdown mek melanoma modulating nras overcame p73 phenocopied restored sensitization sensitized strand suppress ub unanchored vemurafenib
Tagcloud (Intersection) ?