UBTD2 and TRIM39

Number of citations of the paper that reports this interaction (PubMedID 29892012)
71

Data Source:
BioGRID (two hybrid)

		UBTD2	TRIM39
Description		ubiquitin domain containing 2	tripartite motif containing 39
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GO Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process		Apoptotic Process Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein Stabilization Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Anxiety ( 33859377) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Cutaneous lupus erythematosus ( 25827949) Neuroticism ( 29255261)
Interacting Genes		14 interacting genes: AQP6 ARID5A GPS2 INCA1 KLHL35 MRPL17 MVP RNF4 TRIB3 TRIM39 UBA1 UBE2D4 USP5 YPEL3	61 interacting genes: APP CACTIN CCNC DCUN1D1 DCX DIP2A EIF4A2 EPHB6 GAMT HINFP KDM1A LMNA LNX1 LXN MED18 MNAT1 MTURN OTUB2 OTUD6A PDLIM5 PLCD4 POLI PRPF3 PSMA6 PSMB1 PSMD9 RAD23A RECK RNF166 SMCO3 TP53 TRIM17 TRIM21 TRIM8 TTC32 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2N UBE2V1 UBE2W UBL5 UBTD1 UBTD2 UBXN1 UBXN6 UBXN7 USP2 USP39 USP5 WDFY3 ZKSCAN4 ZNF26
Entrez ID		92181	56658
HPRD ID		13118	09298
Ensembl ID		ENSG00000168246	ENSG00000204599
Uniprot IDs		B3KMW8 Q8WUN7	A0A024RCP5 Q9HCM9
PDB IDs		1TTN 2KSN	2DID 2DIF 2ECJ
Enriched GO Terms of Interacting Partners?		Nitrate Transmembrane Transporter Activity Negative Regulation Of Fat Cell Differentiation Transcription Corepressor Activity Cyclin Binding Negative Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Protein K6-linked Ubiquitination Post-translational Protein Modification Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Kinase Activity Protein Kinase Inhibitor Activity Regulation Of Kinase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Regulation Of Protein Modification Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Proteolysis Negative Regulation Of Kinase Activity Negative Regulation Of Protein Kinase Activity Nucleus Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Kinetochore Assembly Ubiquitin Activating Enzyme Activity Regulation Protein Catabolic Process At Presynapse Negative Regulation Of Metabolic Process Protein K48-linked Ubiquitination Regulation Of T Cell Mediated Immunity Regulation Of Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Autophosphorylation Regulation Of Protein Phosphorylation Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Negative Regulation Of Protein K63-linked Ubiquitination	Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteolysis Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Protein K48-linked Ubiquitination Macromolecule Catabolic Process Protein Monoubiquitination Protein K11-linked Ubiquitination Protein K63-linked Ubiquitination Catabolic Process Nucleus Protein Binding Nucleoplasm Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Ubiquitin Binding Regulation Of Post-translational Protein Modification Ubiquitin Ligase Complex Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Regulation Of Protein Modification Process Cysteine-type Deubiquitinase Activity Transferase Activity Protein Deubiquitination Positive Regulation Of Protein Polyubiquitination UBC13-MMS2 Complex Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Protein Modification By Small Protein Removal Regulation Of Protein Metabolic Process Negative Regulation Of Protein Deubiquitination ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex DNA Repair Cytosol Protein K6-linked Ubiquitination Protein Autoubiquitination Positive Regulation Of Protein Metabolic Process
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