GSG2

Gene Name		germ cell associated 2 (haspin)
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Gene Ontology Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Centrosome Spindle
	Molecular Function	DNA Binding Protein Kinase Activity Protein Binding ATP Binding Histone Kinase Activity (H3-T3 Specific)
	Biological Process	Protein Phosphorylation Mitotic Sister Chromatid Cohesion Intracellular Signal Transduction Protein Localization To Chromosome, Centromeric Region Regulation Of Spindle Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Histone H3-T3 Phosphorylation Involved In Chromosome Passenger Complex Localization To Kinetochore
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: AURKB HIST1H3A
Entrez ID		83903
HPRD ID		17083
Ensembl ID		ENSG00000177602
Uniprot IDs		A0PJ70 Q8TF76
PDB IDs		2VUW 2WB8 3DLZ 3E7V 3F2N 3FMD 3IQ7
Enriched GO Terms of Interacting Partners?		Histone H3-S28 Phosphorylation Spindle Stabilization Abscission Cleavage Furrow Formation Mitotic Spindle Midzone Assembly Mitotic Spindle Elongation Cellular Macromolecular Complex Assembly DNA Replication-dependent Nucleosome Assembly Protein Localization To Kinetochore Negative Regulation Of Cytokinesis Spindle Midzone Assembly Protein Localization To Chromosome, Centromeric Region Negative Regulation Of B Cell Apoptotic Process Attachment Of Spindle Microtubules To Kinetochore Chromatin Organization DNA Methylation On Cytosine Chromatin Silencing At RDNA Histone-serine Phosphorylation Regulation Of B Cell Apoptotic Process Mitotic Spindle Assembly Regulation Of Gene Silencing Chromosome Organization Protein Complex Assembly Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Localization To Chromosome Chromatin Silencing Positive Regulation Of Cytokinesis Negative Regulation Of Microtubule Depolymerization Histone Phosphorylation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Mitotic Spindle Organization Spindle Checkpoint Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Cytokinesis Negative Regulation Of Leukocyte Apoptotic Process Negative Regulation Of Protein Binding Microtubule Anchoring Cellular Response To UV DNA Methylation Regulation Of Lymphocyte Apoptotic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Gene Expression, Epigenetic Cellular Component Assembly Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Spindle Assembly
Tagcloud ?		adapted asp atp atypical bonds catalytic dfg equilibrium h3k4 h3t3 haspin his651ala inserts iodotubercidin kinetic lacks loop lys mitosis motifs neighborhood normally phosphorylates recognition segment stabilized tail thr weakly