NDUFAF2 and LAT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NDUFAF2	LAT
Description		NADH:ubiquinone oxidoreductase complex assembly factor 2	linker for activation of T cells
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex I	Immunological Synapse Golgi Apparatus Plasma Membrane Cell-cell Junction COP9 Signalosome Membrane TCR Signalosome Membrane Raft
	Molecular Function	Protein Binding Protein-containing Complex Binding	Protein Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity Signaling Adaptor Activity Molecular Condensate Scaffold Activity
	Biological Process	Cell Projection Organization Mitochondrial Respiratory Chain Complex I Assembly Cilium Assembly Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus	Adaptive Immune Response Lymphocyte Homeostasis Immune System Process Inflammatory Response Immune Response Signal Transduction Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Gene Expression Calcium-mediated Signaling Membrane Raft Distribution Intracellular Signal Transduction T Cell Activation Mast Cell Degranulation Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Homeostasis Of Number Of Cells T Cell Receptor Signaling Pathway Regulation Of T Cell Activation
Pathways		Complex I biogenesis	GPVI-mediated activation cascade Generation of second messenger molecules
Drugs
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (MOSTest) ( 32665545) Cortical volume ( 32963231) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Parkinson's disease ( 27182965) Subcortical volume (MOSTest) ( 32665545)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Crohn's disease ( 21102463) Educational attainment ( 25201988)
Interacting Genes		9 interacting genes: CYB5B LAT LPAR3 SEC22B SMIM1 SPG21 STX8 TMEM201 TMEM97	96 interacting genes: APH1A ASGR2 BCL2L13 BSCL2 CAMLG CBL CD244 CD3G CD4 CD53 CD8A CDIP1 CLDN2 CLDN5 CLDN7 CREB3 CXorf66 CYBC1 EGFR FAM209A FCGR1A FCGR2A FFAR2 FFAR3 FKBP7 FYN GAB2 GJA8 GJB1 GJB3 GOLM1 GPR101 GPR151 GPR152 GPR42 GRAP GRAP2 GRB2 ITK JSRP1 KASH5 KCTD17 KIR2DL3 LCK LCP2 LEUTX LHFPL1 LHFPL5 LMNA MAP1LC3C MAP4K1 MEOX2 MFF MRPS18B MS4A7 MTIF3 NDUFAF2 OPRM1 PIK3R1 PLCG1 PLCG2 PRR4 PSCA PTPN1 PTPN6 PTPRJ SAR1A SERINC2 SGTA SGTB SH3BP2 SHB SLA SLC14A2 SLC16A2 SLC18A1 SLC19A3 SLC26A6 SLC35H1 SLC51B SLC61A1 SLC71A2 SLPI SSMEM1 SYK SYT2 THAP4 TM4SF18 TMEM237 TMEM45B TMEM80 TNFRSF10D VAV1 ZAP70 ZDHHC7 ZHX2
Entrez ID		91942	27040
HPRD ID		14288	03832
Ensembl ID		ENSG00000164182	ENSG00000213658
Uniprot IDs		A0A0S2Z5U1 Q8N183	O43561
PDB IDs
Enriched GO Terms of Interacting Partners?		Collateral Sprouting	Phosphotyrosine Residue Binding Membrane Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Plasma Membrane Immune Response-activating Signaling Pathway Cell-cell Junction Activation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Immune Response Positive Regulation Of Immune Response Fc Receptor Signaling Pathway Lymphocyte Activation Leukocyte Activation Immune System Process Regulation Of Immune System Process Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Binding Signal Transduction Fc-gamma Receptor Signaling Pathway Cell Activation T Cell Activation Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Immune Effector Process B Cell Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Lymphocyte Differentiation T Cell Differentiation Positive Regulation Of Immune Effector Process Membrane Raft T Cell Receptor Complex Neurotrophin TRKA Receptor Binding Gamma-delta T Cell Activation Non-membrane Spanning Protein Tyrosine Kinase Activity Leukocyte Mediated Cytotoxicity Regulation Of Transport Lymphocyte Mediated Immunity T Cell Costimulation Adaptive Immune Response Leukocyte Differentiation Peptidyl-tyrosine Phosphorylation Fc-epsilon Receptor Signaling Pathway Identical Protein Binding Positive Regulation Of Transport Mononuclear Cell Differentiation
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