CD48 and IL18RAP

Number of citations: 0 (PubMedID 15760905)
Data Source: HPRD (in vivo)

		CD48	IL18RAP
Name		CD48 molecule	interleukin 18 receptor accessory protein
Structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Membrane Raft Extracellular Exosome Side Of Membrane	Plasma Membrane Cell Surface Membrane Interleukin-18 Receptor Complex
	Molecular Function	Protein Binding Receptor Ligand Activity	Protein Binding Coreceptor Activity Hydrolase Activity Signaling Receptor Activity Interleukin-18 Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
	Biological Process	Defense Response Immune Response Signal Transduction Natural Killer Cell Activation Leukocyte Activation	Adaptive Immune Response Immune System Process Inflammatory Response Immune Response Signal Transduction Cell Population Proliferation Interleukin-18-mediated Signaling Pathway Neutrophil Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Hydrogen Peroxide Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-18
Pathways		Cell surface interactions at the vascular wall	Interleukin-18 signaling
GWAS		Blood protein levels ( 30072576 ) Inflammatory bowel disease ( 23128233 ) Itch intensity from mosquito bite ( 28199695 ) Multiple sclerosis ( 31604244 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 )	Allergic disease (asthma, hay fever or eczema) ( 29785011 ) Allergic sensitization ( 23817571 ) Asthma ( 31959851 31619474 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Atopic dermatitis ( 23042114 26482879 ) Basophil percentage of white cells ( 32888494 ) Blood protein levels ( 30072576 ) Celiac disease ( 20190752 22057235 18311140 ) Crohn's disease ( 28067908 21102463 ) Delirium ( 29631748 ) Extranodal natural killer T-cell lymphoma (nasal type) ( 31879220 ) Inflammatory bowel disease ( 28067908 23128233 ) Leprosy ( 25642632 ) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 27863252 ) Primary biliary cholangitis ( 26394269 ) Serum protein levels (sST2) ( 23999434 ) Systemic lupus erythematosus ( 28714469 )
Interacting Genes		10 interacting genes: BRIX1 CD2 CD244 CD247 EEF1D FYN GNAI3 IL18R1 IL18RAP LCK	4 interacting genes: APP CD48 IL18 TRIM54
Entrez ID		962	8807
HPRD ID		00177	05147
Ensembl ID		ENSG00000117091	ENSG00000115607
Uniprot IDs		A0A087X1S7 P09326	O95256
PDB IDs		2EDO	3WO4 6KN9 7FCH
GO Terms Enriched among Interactors		Leukocyte Activation Natural Killer Cell Activation Cell Activation Lymphocyte Activation T Cell Activation Adaptive Immune Response Interleukin-18 Receptor Complex Interleukin-18 Receptor Activity Ephrin Receptor Binding Fc-gamma Receptor Signaling Pathway CD8 Receptor Binding Signaling Receptor Activity Ephrin Receptor Signaling Pathway Fc Receptor Signaling Pathway CD4 Receptor Binding Plasma Membrane Phospholipase Activator Activity Positive Regulation Of Type II Interferon Production T Cell Receptor Binding Positive Regulation Of Immune System Process Interleukin-18-mediated Signaling Pathway NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Signal Transduction Phosphatidylinositol 3-kinase Binding Cell Surface Receptor Signaling Pathway Immune Response T Cell Receptor Signaling Pathway Gamma-delta T Cell Activation Phospholipase Binding Regulation Of Type II Interferon Production Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Vasculature Development Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Positive Regulation Of Metabolic Process Antigen Receptor-mediated Signaling Pathway Immune System Process Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response Immune Effector Process Signaling Receptor Binding Cellular Response To Glycine Response To Singlet Oxygen Non-membrane Spanning Protein Tyrosine Kinase Activity Cellular Response To Interleukin-18 Positive Regulation Of Macromolecule Metabolic Process T Cell Costimulation Regulation Of Metabolic Process Regulation Of Immune System Process	Receptor Ligand Activity Amyloid-beta Complex Immune Response Growth Cone Lamellipodium Positive Regulation Of Chemokine Production Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Chemokine Production Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Defense Response Positive Regulation Of Type II Interferon Production Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Leukocyte Activation Natural Killer Cell Activation Interleukin-18 Receptor Binding Acetylcholine Receptor Activator Activity PTB Domain Binding Innate Immune Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Defense Response To Symbiont Defense Response To Other Organism Regulation Of Type II Interferon Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Defense Response To Gram-positive Bacterium Lipoprotein Particle Myeloid Leukocyte Activation Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Cell Activation Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Immune System Process Positive Regulation Of Inflammatory Response Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Membrane Raft Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission