CD48 and BRIX1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CD48	BRIX1
Description		CD48 molecule	biogenesis of ribosomes BRX1
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Membrane Raft Extracellular Exosome Side Of Membrane	Nucleus Chromosome Nucleolus
	Molecular Function	Protein Binding Receptor Ligand Activity	RNA Binding Protein Binding RRNA Binding
	Biological Process	Defense Response Immune Response Signal Transduction Natural Killer Cell Activation Leukocyte Activation	Ribosomal Large Subunit Assembly RRNA Processing Ribosome Biogenesis
Pathways		Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Multiple sclerosis ( 31604244) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		10 interacting genes: BRIX1 CD2 CD244 CD247 EEF1D FYN GNAI3 IL18R1 IL18RAP LCK	5 interacting genes: CD48 GSK3B SETDB1 UBA2 UNC119
Entrez ID		962	55299
HPRD ID		00177	16563
Ensembl ID		ENSG00000117091	ENSG00000113460
Uniprot IDs		A0A087X1S7 P09326	Q8TDN6
PDB IDs		2EDO	8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY
Enriched GO Terms of Interacting Partners?		Leukocyte Activation Natural Killer Cell Activation Cell Activation Lymphocyte Activation T Cell Activation Adaptive Immune Response Interleukin-18 Receptor Complex Interleukin-18 Receptor Activity Ephrin Receptor Binding Fc-gamma Receptor Signaling Pathway CD8 Receptor Binding Signaling Receptor Activity Ephrin Receptor Signaling Pathway Fc Receptor Signaling Pathway CD4 Receptor Binding Plasma Membrane Phospholipase Activator Activity Positive Regulation Of Type II Interferon Production T Cell Receptor Binding Positive Regulation Of Immune System Process Interleukin-18-mediated Signaling Pathway NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Signal Transduction Phosphatidylinositol 3-kinase Binding Cell Surface Receptor Signaling Pathway Immune Response T Cell Receptor Signaling Pathway Gamma-delta T Cell Activation Phospholipase Binding Regulation Of Type II Interferon Production Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Vasculature Development Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Positive Regulation Of Metabolic Process Antigen Receptor-mediated Signaling Pathway Immune System Process Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response Immune Effector Process Signaling Receptor Binding Cellular Response To Glycine Response To Singlet Oxygen Non-membrane Spanning Protein Tyrosine Kinase Activity Cellular Response To Interleukin-18 Positive Regulation Of Macromolecule Metabolic Process T Cell Costimulation Regulation Of Metabolic Process Regulation Of Immune System Process	Positive Regulation Of Post-translational Protein Modification Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Regulation Of Protein Modification Process Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Microtubule Anchoring At Centrosome Positive Regulation Of Protein Modification Process Negative Regulation Of Caveolin-mediated Endocytosis SUMO Activating Enzyme Activity SUMO Activating Enzyme Complex Positive Regulation Of Protein Metabolic Process Negative Regulation Of TORC2 Signaling Negative Regulation Of Dopaminergic Neuron Differentiation Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Clathrin-dependent Endocytosis Histone H3K9 Trimethyltransferase Activity Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cilium Cellular Response To Interleukin-3 Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Localization To Centrosome Regulation Of Caveolin-mediated Endocytosis Histone H3K9 Monomethyltransferase Activity Ubiquitin-like Protein Conjugating Enzyme Binding Small Protein Activating Enzyme Binding Negative Regulation Of Glycogen Biosynthetic Process ER Overload Response Regulation Of Protein Localization To Cilium Regulation Of Dopaminergic Neuron Differentiation Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Protein Binding Regulation Of Mesenchymal Stem Cell Differentiation Positive Regulation Of Protein Tyrosine Kinase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Methyltransferase Activity Ubiquitin-like Modifier Activating Enzyme Activity SUMO Binding Beta-catenin Destruction Complex Regulation Of Protein Localization To Centrosome Heterochromatin Organization Wnt Signalosome Regulation Of TORC2 Signaling Positive Regulation Of Protein Sumoylation TORC2 Signaling Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Cellular Response To Heat Maintenance Of Cell Polarity Protein Kinase A Catalytic Subunit Binding
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