ARHGEF2 and RRAS2

Number of citations of the paper that reports this interaction (PubMedID 12384139)
0

Data Source:
HPRD (in vitro)

		ARHGEF2	RRAS2
Description		Rho/Rac guanine nucleotide exchange factor 2	RAS related 2
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Spindle Cytosol Cytoskeleton Microtubule Plasma Membrane Bicellular Tight Junction Focal Adhesion Membrane Cytoplasmic Vesicle Vesicle Ruffle Membrane Protein-containing Complex Cell Projection Anchoring Junction	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Focal Adhesion Membrane Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Microtubule Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding
	Biological Process	Cell Morphogenesis Immune System Process Intracellular Protein Transport Actin Filament Organization Negative Regulation Of Microtubule Depolymerization Nervous System Development Cell Differentiation Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Rho Protein Signal Transduction Regulation Of Cell Population Proliferation Innate Immune Response Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Division Asymmetric Neuroblast Division Negative Regulation Of Necroptotic Process Cellular Response To Muramyl Dipeptide Cellular Response To Tumor Necrosis Factor Cellular Hyperosmotic Response Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Neuron Migration	Osteoblast Differentiation Signal Transduction Ras Protein Signal Transduction Cell Migration Schwann Cell Migration Positive Regulation Of Schwann Cell Migration
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle	RND1 GTPase cycle
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Neuritic plaque ( 31497858) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Alzheimer's disease (cognitive decline) ( 23535033) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mitochondrial DNA levels ( 25240745) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Refractive error ( 32231278) Vitamin D levels ( 25208829) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		13 interacting genes: CEBPA CGN MARK3 NFKBID PAK1 PTPRF RAC1 RHOA RNF10 RRAS2 YWHAE YWHAG YWHAZ	33 interacting genes: ACVR1 AFDN AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB HDAC7 LGALS4 LINC00632 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAP1GDS1 RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RGL3 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6
Entrez ID		9181	22800
HPRD ID		10458	02518
Ensembl ID		ENSG00000116584	ENSG00000133818
Uniprot IDs		Q92974	P62070
PDB IDs		5EFX 7G80 7G81 7G82 7G83 7G84 7G85 7G86 7G87 7G88 7G89 7G8A 7G8B 7G8C 7G8D 7G8E 7G8F 7G8G 7G8H 7G8I 7G8J 7G8K 7G8L 7G8M 7G8N 7G8O 7G8P 7G8Q 7G8R 7G8S 7G8T 7G8U 7G8V 7G8W 7G8X 7G8Y 7G8Z 7G90 7G91 7G92 7G93 7G94 7G95 7G96 7G97 7G98 7G99 7G9A 7G9B 7G9C 7G9D 7G9E 7G9F 7G9G 7G9H 7G9I 7G9J 8BNT	2ERY 9B4Q 9B4S
Enriched GO Terms of Interacting Partners?		Focal Adhesion Intracellular Signal Transduction Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Immune System Process Regulation Of Immune System Process Protein Sequestering Activity Positive Regulation Of Stress Fiber Assembly Phosphoserine Residue Binding Regulation Of Developmental Process Positive Regulation Of Actin Filament Bundle Assembly Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of Cell Development Protein Domain Specific Binding Cell Migration Regulation Of Protein Localization Extracellular Exosome Regulation Of Stress Fiber Assembly Protein Phosphatase Binding Regulation Of Cell Differentiation Ruffle Membrane Melanosome Cell Motility Positive Regulation Of Cell Activation Neuron Migration Establishment Or Maintenance Of Cell Polarity Cerebral Cortex Cell Migration Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Microtubule Polymerization Protein Kinase Binding Vesicle Dendrite Positive Regulation Of Cytoskeleton Organization Cellular Response To Starvation Lamellipodium Regulation Of Neuron Differentiation Response To Nutrient Levels Positive Regulation Of Cell Adhesion Regulation Of Multicellular Organismal Process Positive Regulation Of Protein-containing Complex Assembly Regulation Of Fibroblast Migration Protein Targeting Telencephalon Cell Migration Semaphorin-plexin Signaling Pathway Regulation Of Immune Response Substantia Nigra Development	Guanyl-nucleotide Exchange Factor Activity Intracellular Signaling Cassette Signal Transduction Ras Protein Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Apoptotic Process Cytosol Regulation Of Programmed Cell Death SMAD Binding Negative Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Apoptotic Signaling Pathway Small GTPase-mediated Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Bone Mineralization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Small GTPase Binding Regulation Of Protein Modification Process Intracellular Glucose Homeostasis Enzyme-linked Receptor Protein Signaling Pathway Activin Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Response To BMP Stimulus Response To Growth Factor Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Transforming Growth Factor Beta Receptor Activity, Type I Regulation Of Cell Population Proliferation Protein Prenyltransferase Activity Apoptotic Signaling Pathway Establishment Of Endothelial Barrier Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Endothelial Cell Development
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