RRAS2 and FNTB

Number of citations of the paper that reports this interaction (PMID 15451670)
58

Data Source:
HPRD (in vitro)

		RRAS2	FNTB
Gene Name		related RAS viral (r-ras) oncogene homolog 2	farnesyltransferase, CAAX box, beta
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Focal Adhesion Membrane Extracellular Vesicular Exosome	Cytosol Microtubule Associated Complex Protein Farnesyltransferase Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding	Farnesyltranstransferase Activity Protein Farnesyltransferase Activity Protein Binding Drug Binding Zinc Ion Binding Isoprenoid Binding Peptide Binding
	Biological Process	Osteoblast Differentiation Ras Protein Signal Transduction Positive Regulation Of Cell Migration Regulation Of Neuron Death	Phototransduction, Visible Light Negative Regulation Of Cell Proliferation Response To Inorganic Substance Response To Organic Cyclic Compound Rhodopsin Mediated Signaling Pathway Protein Farnesylation Regulation Of Rhodopsin Mediated Signaling Pathway Response To Cytokine Wound Healing Positive Regulation Of Cell Cycle Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Pathways			Inactivation, recovery and regulation of the phototransduction cascade Visual phototransduction The phototransduction cascade Diseases associated with visual transduction
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033)	Blood trace element (Zn levels) ( 23720494) Mean corpuscular volume ( 19862010) Red blood cell traits ( 23222517)
Protein-Protein Interactions		29 interactors: ACVR1 AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB LGALS4 MLLT4 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6	9 interactors: CENPF FNTA GBP1 HDAC6 HRAS KRAS PTP4A3 RAP2A RRAS2
Entrez ID		22800	2342
HPRD ID		02518	00608
Ensembl ID		ENSG00000133818	ENSG00000257365
Uniprot IDs		B7Z5Z2 P62070	P49356
PDB IDs		2ERY	1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Metabolic Process Signal Transduction Response To Stimulus Signaling Cell Communication Positive Regulation Of Metabolic Process Cellular Response To Stimulus Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Catalytic Activity Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Hydrolase Activity Cellular Response To Growth Factor Stimulus Regulation Of Protein Phosphorylation Response To Growth Factor Regulation Of Intracellular Signal Transduction Endothelial Cell Differentiation Positive Regulation Of Catalytic Activity Regulation Of Cell Death Endothelium Development Regulation Of Cellular Protein Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cellular Process Regulation Of GTPase Activity Response To Stress Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Cell Proliferation Negative Regulation Of Signaling Regulation Of Ras Protein Signal Transduction Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Negative Regulation Of Cell Death Positive Regulation Of Rap GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Bone Mineralization Defense Response BMP Signaling Pathway Regulation Of Cytokine Production Regulation Of Ras GTPase Activity Regulation Of Protein Localization	Ras Protein Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Migration Response To Growth Factor Small GTPase Mediated Signal Transduction Regulation Of Cell Motility Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Locomotion Regulation Of Synaptic Transmission, GABAergic Regulation Of Cellular Component Movement Regulation Of Rac Protein Signal Transduction Social Behavior Epithelial Tube Branching Involved In Lung Morphogenesis Regulation Of Neuron Death Positive Regulation Of Ras Protein Signal Transduction Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Response To Light Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Component Movement Positive Regulation Of Small GTPase Mediated Signal Transduction Visual Learning Response To External Stimulus Positive Regulation Of Locomotion Visual Behavior Activation Of MAPKK Activity Lung Morphogenesis Cellular Response To Organic Substance Regulation Of Oxidoreductase Activity Positive Regulation Of Tubulin Deacetylation Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Hsp90 Deacetylation Associative Learning Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Response To Radiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Muscle Structure Development Positive Regulation Of Chaperone-mediated Protein Complex Assembly Polyubiquitinated Misfolded Protein Transport Regulation Of Receptor Activity Cell Communication Cellular Response To Growth Factor Stimulus Response To Organic Substance Learning Actin Cytoskeleton Organization
Tagcloud ?			annotation atad5 automatically becn1 cdkn2a centered clusterone cytoscape david e2f e2f1 geneways kegg kras language module modules mp neurofibromatosis nf1 nf2 nsclc orthologous phenotypes proven successively systemically thyroglobulin visualization
Tagcloud (Difference) ?			annotation atad5 automatically becn1 cdkn2a centered clusterone cytoscape david e2f e2f1 geneways kegg kras language module modules mp neurofibromatosis nf1 nf2 nsclc orthologous phenotypes proven successively systemically thyroglobulin visualization
Tagcloud (Intersection) ?