RRAS2 and PAWR

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		RRAS2	PAWR
Description		RAS related 2	pro-apoptotic WT1 regulator
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Focal Adhesion Membrane Extracellular Exosome	Chromatin Nucleus Cytoplasm Cytosol Actin Filament Plasma Membrane Actin Cytoskeleton
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding	Transcription Corepressor Activity Actin Binding Protein Binding Enzyme Binding Leucine Zipper Domain Binding
	Biological Process	Osteoblast Differentiation Signal Transduction Ras Protein Signal Transduction Cell Migration Schwann Cell Migration Positive Regulation Of Schwann Cell Migration	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of B Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Fibroblast Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Apoptotic Signaling Pathway Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Cellular Senescence
Pathways		RND1 GTPase cycle
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mitochondrial DNA levels ( 25240745) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Refractive error ( 32231278) Vitamin D levels ( 25208829) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		33 interacting genes: ACVR1 AFDN AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB HDAC7 LGALS4 LINC00632 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAP1GDS1 RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RGL3 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6	14 interacting genes: AATF ATP5F1C DAPK3 DRD2 HSPA5 PML PRKCZ RRAS2 SLC5A7 SPSB1 SQSTM1 TFPT THAP1 WT1
Entrez ID		22800	5074
HPRD ID		02518	09051
Ensembl ID		ENSG00000133818	ENSG00000177425
Uniprot IDs		P62070	Q96IZ0
PDB IDs		2ERY 9B4Q 9B4S	2JK9
Enriched GO Terms of Interacting Partners?		Guanyl-nucleotide Exchange Factor Activity Intracellular Signaling Cassette Signal Transduction Ras Protein Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Apoptotic Process Cytosol Regulation Of Programmed Cell Death SMAD Binding Negative Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Apoptotic Signaling Pathway Small GTPase-mediated Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Bone Mineralization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Small GTPase Binding Regulation Of Protein Modification Process Intracellular Glucose Homeostasis Enzyme-linked Receptor Protein Signaling Pathway Activin Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Response To BMP Stimulus Response To Growth Factor Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Transforming Growth Factor Beta Receptor Activity, Type I Regulation Of Cell Population Proliferation Protein Prenyltransferase Activity Apoptotic Signaling Pathway Establishment Of Endothelial Barrier Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Endothelial Cell Development	PML Body Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Leucine Zipper Domain Binding Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Regulation Of DNA-templated Transcription Regulation Of Cellular Component Organization Intracellular Signal Transduction Regulation Of RNA Biosynthetic Process Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Synaptic Transmission Morphogenesis Of A Branching Structure Ionotropic Glutamate Receptor Binding Response To Interleukin-4 Cellular Response To Interleukin-4 Regulation Of RNA Metabolic Process Temperature Homeostasis Negative Regulation Of Translation Regulation Of Synaptic Plasticity Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Programmed Cell Death Maintenance Of Protein Localization In Organelle Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Myosin II Filament Organization Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Protein Folding In Endoplasmic Reticulum Negative Regulation Of Translation In Response To Oxidative Stress Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Choline:sodium Symporter Activity Regulation Of Macromolecule Biosynthetic Process Maintenance Of Protein Location In Cell Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Circadian Regulation Of Gene Expression G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Positive Regulation Of DNA-templated Transcription Protein Catabolic Process Cerebellum Structural Organization Maintenance Of Protein Location Maintenance Of Location In Cell Positive Regulation Of Telomere Maintenance Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development
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