ARHGEF2 and CGN

Number of citations of the paper that reports this interaction (PubMedID 15866167)
0

Data Source:
HPRD (in vitro, in vivo)

		ARHGEF2	CGN
Description		Rho/Rac guanine nucleotide exchange factor 2	cingulin
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Spindle Cytosol Cytoskeleton Microtubule Plasma Membrane Bicellular Tight Junction Focal Adhesion Membrane Cytoplasmic Vesicle Vesicle Ruffle Membrane Protein-containing Complex Cell Projection Anchoring Junction	Plasma Membrane Bicellular Tight Junction Myosin Complex Cell Junction Anchoring Junction
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Microtubule Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding	Actin Binding Protein Binding Microtubule Binding Cadherin Binding
	Biological Process	Cell Morphogenesis Immune System Process Intracellular Protein Transport Actin Filament Organization Negative Regulation Of Microtubule Depolymerization Nervous System Development Cell Differentiation Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Rho Protein Signal Transduction Regulation Of Cell Population Proliferation Innate Immune Response Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Division Asymmetric Neuroblast Division Negative Regulation Of Necroptotic Process Cellular Response To Muramyl Dipeptide Cellular Response To Tumor Necrosis Factor Cellular Hyperosmotic Response Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Neuron Migration	Microtubule Cytoskeleton Organization
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Neuritic plaque ( 31497858) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Body mass index ( 26426971)
Interacting Genes		13 interacting genes: CEBPA CGN MARK3 NFKBID PAK1 PTPRF RAC1 RHOA RNF10 RRAS2 YWHAE YWHAG YWHAZ	10 interacting genes: ARHGEF2 CDC42 F11R LNX1 PPP1R13B RNF10 TJP1 TJP2 TP53BP2 YWHAG
Entrez ID		9181	57530
HPRD ID		10458	10827
Ensembl ID		ENSG00000116584	ENSG00000143375
Uniprot IDs		Q92974	Q9P2M7
PDB IDs		5EFX 7G80 7G81 7G82 7G83 7G84 7G85 7G86 7G87 7G88 7G89 7G8A 7G8B 7G8C 7G8D 7G8E 7G8F 7G8G 7G8H 7G8I 7G8J 7G8K 7G8L 7G8M 7G8N 7G8O 7G8P 7G8Q 7G8R 7G8S 7G8T 7G8U 7G8V 7G8W 7G8X 7G8Y 7G8Z 7G90 7G91 7G92 7G93 7G94 7G95 7G96 7G97 7G98 7G99 7G9A 7G9B 7G9C 7G9D 7G9E 7G9F 7G9G 7G9H 7G9I 7G9J 8BNT
Enriched GO Terms of Interacting Partners?		Focal Adhesion Intracellular Signal Transduction Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Immune System Process Regulation Of Immune System Process Protein Sequestering Activity Positive Regulation Of Stress Fiber Assembly Phosphoserine Residue Binding Regulation Of Developmental Process Positive Regulation Of Actin Filament Bundle Assembly Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of Cell Development Protein Domain Specific Binding Cell Migration Regulation Of Protein Localization Extracellular Exosome Regulation Of Stress Fiber Assembly Protein Phosphatase Binding Regulation Of Cell Differentiation Ruffle Membrane Melanosome Cell Motility Positive Regulation Of Cell Activation Neuron Migration Establishment Or Maintenance Of Cell Polarity Cerebral Cortex Cell Migration Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Microtubule Polymerization Protein Kinase Binding Vesicle Dendrite Positive Regulation Of Cytoskeleton Organization Cellular Response To Starvation Lamellipodium Regulation Of Neuron Differentiation Response To Nutrient Levels Positive Regulation Of Cell Adhesion Regulation Of Multicellular Organismal Process Positive Regulation Of Protein-containing Complex Assembly Regulation Of Fibroblast Migration Protein Targeting Telencephalon Cell Migration Semaphorin-plexin Signaling Pathway Regulation Of Immune Response Substantia Nigra Development	Establishment Of Endothelial Intestinal Barrier Protein Localization To Cell-cell Junction Maintenance Of Blood-brain Barrier Tight Junction Establishment Of Endothelial Barrier Bicellular Tight Junction Endothelial Cell Development Positive Regulation Of Blood-brain Barrier Permeability Protein Localization To Bicellular Tight Junction Regulation Of Blood-brain Barrier Permeability Protein Localization To Cell Junction Regulation Of Stress Fiber Assembly Positive Regulation Of Vascular Permeability Regulation Of Supramolecular Fiber Organization Epithelial Cell Development Anchoring Junction Regulation Of Bicellular Tight Junction Assembly Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Cell Junction Organization Cell-cell Junction Organization Positive Regulation Of Cell Adhesion Intestinal Absorption Anatomical Structure Homeostasis Tissue Homeostasis Negative Regulation Of Stress Fiber Assembly Regulation Of Cytoskeleton Organization Intracellular Protein Localization Cell Junction Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Vascular Permeability Regulation Of Actin Filament Organization Adherens Junction Organization Negative Regulation Of Cellular Component Organization Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Protein-containing Complex Cadherin Binding Regulation Of Membrane Permeability Circulatory System Process Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion P53 Binding Regulation Of Actin Cytoskeleton Organization Digestive System Process Ubiquitin Protein Ligase Activity Actin Cytoskeleton Organization PDZ Domain Binding Regulation Of Actin Filament-based Process Apical Part Of Cell GBD Domain Binding
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