ARHGEF2 and PTPRF

Number of citations of the paper that reports this interaction (PubMedID 25458010)
51

Data Source:
BioGRID (affinity chromatography technology, two hybrid, pull down)

		ARHGEF2	PTPRF
Description		Rho/Rac guanine nucleotide exchange factor 2	protein tyrosine phosphatase receptor type F
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Spindle Cytosol Cytoskeleton Microtubule Plasma Membrane Bicellular Tight Junction Focal Adhesion Membrane Cytoplasmic Vesicle Vesicle Ruffle Membrane Protein-containing Complex Cell Projection Anchoring Junction	Plasma Membrane Membrane Neuron Projection Neuronal Cell Body Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Microtubule Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Heparin Binding Hydrolase Activity Chondroitin Sulfate Proteoglycan Binding Protein-containing Complex Binding Cell Adhesion Molecule Binding
	Biological Process	Cell Morphogenesis Immune System Process Intracellular Protein Transport Actin Filament Organization Negative Regulation Of Microtubule Depolymerization Nervous System Development Cell Differentiation Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Rho Protein Signal Transduction Regulation Of Cell Population Proliferation Innate Immune Response Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Division Asymmetric Neuroblast Division Negative Regulation Of Necroptotic Process Cellular Response To Muramyl Dipeptide Cellular Response To Tumor Necrosis Factor Cellular Hyperosmotic Response Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Neuron Migration	Cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Nervous System Development Regulation Of Neuron Projection Development Cell Migration Neuron Projection Regeneration Peptidyl-tyrosine Dephosphorylation Regulation Of Axon Regeneration Synaptic Membrane Adhesion Negative Regulation Of Receptor Binding
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle	Receptor-type tyrosine-protein phosphatases Insulin receptor recycling Synaptic adhesion-like molecules
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Neuritic plaque ( 31497858) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Adventurousness ( 30643258) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention deficit hyperactivity disorder ( 33495439 30478444) Attention deficit hyperactivity disorder or cannabis use ( 30610198) Autism spectrum disorder or schizophrenia ( 28540026) Coffee consumption ( 31046077) Cognitive ability (MTAG) ( 29186694) Disruptive behavior disorder and attention deficit hyperactivity disorder ( 33495439) Educational attainment ( 27046643) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Household income (MTAG) ( 31844048) Intake of total sugars ( 31005972) Intelligence (MTAG) ( 29326435) Mean reticulocyte volume ( 32888494) Refractive error ( 32231278) Schizophrenia ( 30285260 29483656 28991256 25056061) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Urate levels ( 31578528)
Interacting Genes		13 interacting genes: CEBPA CGN MARK3 NFKBID PAK1 PTPRF RAC1 RHOA RNF10 RRAS2 YWHAE YWHAG YWHAZ	59 interacting genes: ACAN ACAT1 ACTB ARHGEF11 ARHGEF12 ARHGEF2 ATP5F1A BCAR1 CAV1 CBR1 CDH1 CREBBP CTNNB1 DEPDC1B DIAPH1 EEF1A1 EEF1G FRS2 FYN GALNT1 GAPDH GPC4 HSP90AA1 HSPA1A HSPA1L HSPA5 HSPA8 HSPA9 INSR IRS1 IRS2 JUP LACTB LCK LDHA LDHB NCAN NID1 OMG PPFIA1 PPFIA2 PPFIA3 PRPF40A PTPRA PTPRD PTPRZ1 RAP1GDS1 RET RHOA ROCK2 SEMG1 SEMG2 SEPTIN9 SKIL SOWAHC TRIO TUBA1B VCAN ZNF512B
Entrez ID		9181	5792
HPRD ID		10458	01552
Ensembl ID		ENSG00000116584	ENSG00000142949
Uniprot IDs		Q92974	G1UI20 P10586
PDB IDs		5EFX 7G80 7G81 7G82 7G83 7G84 7G85 7G86 7G87 7G88 7G89 7G8A 7G8B 7G8C 7G8D 7G8E 7G8F 7G8G 7G8H 7G8I 7G8J 7G8K 7G8L 7G8M 7G8N 7G8O 7G8P 7G8Q 7G8R 7G8S 7G8T 7G8U 7G8V 7G8W 7G8X 7G8Y 7G8Z 7G90 7G91 7G92 7G93 7G94 7G95 7G96 7G97 7G98 7G99 7G9A 7G9B 7G9C 7G9D 7G9E 7G9F 7G9G 7G9H 7G9I 7G9J 8BNT	1LAR 2DJU 2DN7 2EDX 2EDY 2YD5 2YD8 4N5U 6KR4 6TPT 6TPU 6TPV 6TPW
Enriched GO Terms of Interacting Partners?		Focal Adhesion Intracellular Signal Transduction Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Immune System Process Regulation Of Immune System Process Protein Sequestering Activity Positive Regulation Of Stress Fiber Assembly Phosphoserine Residue Binding Regulation Of Developmental Process Positive Regulation Of Actin Filament Bundle Assembly Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of Cell Development Protein Domain Specific Binding Cell Migration Regulation Of Protein Localization Extracellular Exosome Regulation Of Stress Fiber Assembly Protein Phosphatase Binding Regulation Of Cell Differentiation Ruffle Membrane Melanosome Cell Motility Positive Regulation Of Cell Activation Neuron Migration Establishment Or Maintenance Of Cell Polarity Cerebral Cortex Cell Migration Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Microtubule Polymerization Protein Kinase Binding Vesicle Dendrite Positive Regulation Of Cytoskeleton Organization Cellular Response To Starvation Lamellipodium Regulation Of Neuron Differentiation Response To Nutrient Levels Positive Regulation Of Cell Adhesion Regulation Of Multicellular Organismal Process Positive Regulation Of Protein-containing Complex Assembly Regulation Of Fibroblast Migration Protein Targeting Telencephalon Cell Migration Semaphorin-plexin Signaling Pathway Regulation Of Immune Response Substantia Nigra Development	Extracellular Exosome Protein Refolding Phosphatidylinositol 3-kinase Binding ATP-dependent Protein Folding Chaperone Focal Adhesion Perineuronal Net Disordered Domain Specific Binding Protein Folding Chaperone Cell Adhesion Regulation Of Developmental Process Regulation Of Cellular Component Organization Regulation Of Protein Localization Cellular Response To Indole-3-methanol Tau Protein Binding Response To Indole-3-methanol Lysosomal Lumen Regulation Of Cell Motility Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Cell Motility Regulation Of Locomotion Cadherin Binding Regulation Of Signal Transduction Apical Junction Complex Regulation Of Intracellular Signal Transduction Regulation Of Cell Differentiation Regulation Of Anatomical Structure Morphogenesis Heat Shock Protein Binding Unfolded Protein Binding Cellular Response To Oxygen-containing Compound Nucleotide Binding Plasma Membrane Enzyme-linked Receptor Protein Signaling Pathway Cell Migration Regulation Of Intrinsic Apoptotic Signaling Pathway G Protein-coupled Receptor Binding Positive Regulation Of Cell Migration ATP Hydrolysis Activity Developmental Process Positive Regulation Of Cell Motility Positive Regulation Of Multicellular Organismal Process Presynaptic Active Zone Positive Regulation Of Locomotion Regulation Of Cell Migration Ubiquitin Protein Ligase Binding Substantia Nigra Development Regulation Of Multicellular Organismal Development Response To Hormone Regulation Of Apoptotic Process
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