RRAS2 and RAPGEF4

Number of citations of the paper that reports this interaction (PubMedID 12384139)
0

Data Source:
HPRD (in vitro)

		RRAS2	RAPGEF4
Description		RAS related 2	Rap guanine nucleotide exchange factor 4
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Focal Adhesion Membrane Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Membrane Hippocampal Mossy Fiber To CA3 Synapse
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding	Nucleotide Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding CAMP Binding Protein-macromolecule Adaptor Activity Small GTPase Binding
	Biological Process	Osteoblast Differentiation Signal Transduction Ras Protein Signal Transduction Cell Migration Schwann Cell Migration Positive Regulation Of Schwann Cell Migration	Adaptive Immune Response Exocytosis G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Calcium-ion Regulated Exocytosis Regulation Of Exocytosis Insulin Secretion Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Hormone Secretion Regulation Of Insulin Secretion Regulation Of Synaptic Vesicle Cycle
Pathways		RND1 GTPase cycle	Integrin signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mitochondrial DNA levels ( 25240745) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Refractive error ( 32231278) Vitamin D levels ( 25208829) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Fasting blood glucose ( 33842983) Fasting plasma glucose ( 25187374) GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) HDL cholesterol levels ( 32203549) Hippocampal volume ( 25625606) Lateral ventricle temporal horn volume ( 31530798)
Interacting Genes		33 interacting genes: ACVR1 AFDN AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB HDAC7 LGALS4 LINC00632 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAP1GDS1 RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RGL3 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6	14 interacting genes: ATXN1 BMERB1 DEF6 DSCAM LRRK2 MAP1A RAP1A RAP2A RIMS2 RRAS2 SWAP70 TRAF2 TSPOAP1 ZC3H11A
Entrez ID		22800	11069
HPRD ID		02518	06929
Ensembl ID		ENSG00000133818	ENSG00000091428
Uniprot IDs		P62070	B7Z278 E9PB94 Q8WZA2 X5D7N4
PDB IDs		2ERY 9B4Q 9B4S
Enriched GO Terms of Interacting Partners?		Guanyl-nucleotide Exchange Factor Activity Intracellular Signaling Cassette Signal Transduction Ras Protein Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Apoptotic Process Cytosol Regulation Of Programmed Cell Death SMAD Binding Negative Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Apoptotic Signaling Pathway Small GTPase-mediated Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Bone Mineralization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Small GTPase Binding Regulation Of Protein Modification Process Intracellular Glucose Homeostasis Enzyme-linked Receptor Protein Signaling Pathway Activin Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Response To BMP Stimulus Response To Growth Factor Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Transforming Growth Factor Beta Receptor Activity, Type I Regulation Of Cell Population Proliferation Protein Prenyltransferase Activity Apoptotic Signaling Pathway Establishment Of Endothelial Barrier Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Endothelial Cell Development	Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Vesicle Exocytosis Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission GDP Binding Rap Protein Signal Transduction Regulation Of Cell Communication Regulation Of Protein Depolymerization Regulation Of Signaling Small GTPase-mediated Signal Transduction Cellular Localization GTPase Activity Regulation Of Locomotion Regulation Of Protein-containing Complex Disassembly Regulation Of Regulated Secretory Pathway Regulation Of Glial Cell Migration GTP Binding Cell Projection Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Regulation Of Biological Quality Regulation Of Microtubule Depolymerization Regulation Of Exocytosis Intracellular Signaling Cassette Locomotory Behavior Post-embryonic Retina Morphogenesis In Camera-type Eye Positive Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Locomotion Cell Projection Morphogenesis Netrin Receptor Binding Positive Regulation Of Phosphorylation Social Behavior Neuron Projection Morphogenesis Synapse Synapse Organization Tubulin Binding Retrograde Axonal Protein Transport Primary Dendrite Establishment Of Localization In Cell Neuron Cellular Homeostasis Regulation Of Signal Transduction Small GTPase Binding Response To Antineoplastic Agent Guanyl-nucleotide Exchange Factor Activity Regulation Of MAPK Cascade Regulation Of Secretion Regulation Of Secretion By Cell G Protein Activity Nuclear Transport
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