ARHGEF2

Gene Name		Rho/Rac guanine nucleotide exchange factor (GEF) 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Spindle Cytosol Cytoskeleton Microtubule Tight Junction Focal Adhesion Cytoplasmic Membrane-bounded Vesicle Vesicle Ruffle Membrane Neuronal Cell Body Dendritic Shaft Protein Complex
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Microtubule Binding Transcription Factor Binding Zinc Ion Binding Rho GTPase Binding Rac Guanyl-nucleotide Exchange Factor Activity Rac GTPase Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Cell Morphogenesis Intracellular Protein Transport Actin Filament Organization Negative Regulation Of Microtubule Depolymerization Mitotic Nuclear Division Small GTPase Mediated Signal Transduction Positive Regulation Of Rho GTPase Activity Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Rac GTPase Activity Regulation Of Rho Protein Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Neurogenesis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Division Negative Regulation Of Necroptotic Process Cellular Response To Muramyl Dipeptide Cellular Response To Tumor Necrosis Factor Cellular Hyperosmotic Response Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728)
Protein-protein Interactions		9 interactors: CGN PAK1 RAC1 RHOA RPP25L RRAS2 YWHAE YWHAG YWHAZ
Entrez ID		9181
HPRD ID		10458
Ensembl ID		ENSG00000116584
Uniprot IDs		Q92974
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Organelle Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Organelle Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Transport Positive Regulation Of Mitochondrion Organization Regulation Of Stress Fiber Assembly Apoptotic Signaling Pathway Membrane Organization Regulation Of Mitochondrion Organization Ephrin Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Organelle Organization Apoptotic Process Cellular Response To Organic Substance Signal Transduction Programmed Cell Death Regulation Of Cellular Component Organization Regulation Of Intracellular Transport Cell Death Death Cell Differentiation Signaling Cell Communication Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Hyperosmotic Response Wound Healing Response To Growth Factor Intrinsic Apoptotic Signaling Pathway Cellular Protein Localization Platelet Activation Positive Regulation Of Cell Death Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Motility Response To Organic Substance Positive Regulation Of Cytoskeleton Organization Cell-cell Junction Organization Cellular Response To Stimulus Neurotrophin TRK Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of Locomotion
Tagcloud ?		bona cd centered crohn disregulated driven exerted fide genic gwass hebp1 interactor italian meta nod2 nonetheless nonselected nsf predisposition preferential prioritize protozoa protozoan shaping signatures snps strongest subject vamp3