RRAS2 and RAPGEF3

Number of citations of the paper that reports this interaction (PMID 12384139)
34

Data Source:
HPRD (in vitro)

		RRAS2	RAPGEF3
Gene Name		related RAS viral (r-ras) oncogene homolog 2	Rap guanine nucleotide exchange factor (GEF) 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Focal Adhesion Membrane Extracellular Vesicular Exosome	Plasma Membrane CAMP-dependent Protein Kinase Complex Endomembrane System Membrane Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Rap Guanyl-nucleotide Exchange Factor Activity CAMP Binding
	Biological Process	Osteoblast Differentiation Ras Protein Signal Transduction Positive Regulation Of Cell Migration Regulation Of Neuron Death	Angiogenesis Energy Reserve Metabolic Process Signal Transduction Blood Coagulation Cell Proliferation CAMP-mediated Signaling Platelet Activation Positive Regulation Of CAMP Catabolic Process Rap Protein Signal Transduction Positive Regulation Of Rap GTPase Activity Small Molecule Metabolic Process Positive Regulation Of Angiogenesis Regulation Of Protein Kinase Activity Regulation Of Insulin Secretion Positive Regulation Of Stress Fiber Assembly Establishment Of Endothelial Barrier Cellular Response To CAMP Regulation Of Actin Cytoskeleton Reorganization
Pathways			Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Integration of energy metabolism Regulation of insulin secretion Integrin alphaIIb beta3 signaling Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) Adaptive Immune System
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033)
Protein-Protein Interactions		29 interactors: ACVR1 AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB LGALS4 MLLT4 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6	6 interactors: AP2B1 MAP1A PNMA1 RAP1A RAP2A RRAS2
Entrez ID		22800	10411
HPRD ID		02518	06928
Ensembl ID		ENSG00000133818	ENSG00000079337
Uniprot IDs		B7Z5Z2 P62070	O95398 Q99777
PDB IDs		2ERY
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Metabolic Process Signal Transduction Response To Stimulus Signaling Cell Communication Positive Regulation Of Metabolic Process Cellular Response To Stimulus Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Catalytic Activity Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Hydrolase Activity Cellular Response To Growth Factor Stimulus Regulation Of Protein Phosphorylation Response To Growth Factor Regulation Of Intracellular Signal Transduction Endothelial Cell Differentiation Positive Regulation Of Catalytic Activity Regulation Of Cell Death Endothelium Development Regulation Of Cellular Protein Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cellular Process Regulation Of GTPase Activity Response To Stress Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Cell Proliferation Negative Regulation Of Signaling Regulation Of Ras Protein Signal Transduction Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Negative Regulation Of Cell Death Positive Regulation Of Rap GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Bone Mineralization Defense Response BMP Signaling Pathway Regulation Of Cytokine Production Regulation Of Ras GTPase Activity Regulation Of Protein Localization	Rap Protein Signal Transduction Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction
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