RRAS2 and PGGT1B

Number of citations of the paper that reports this interaction (PubMedID 15451670)
0

Data Source:
HPRD (in vitro)

		RRAS2	PGGT1B
Description		RAS related 2	protein geranylgeranyltransferase type I subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Focal Adhesion Membrane Extracellular Exosome	CAAX-protein Geranylgeranyltransferase Complex
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding	Catalytic Activity Prenyltransferase Activity Protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Activity Protein Binding Zinc Ion Binding Protein Prenyltransferase Activity Transferase Activity Metal Ion Binding
	Biological Process	Osteoblast Differentiation Signal Transduction Ras Protein Signal Transduction Cell Migration Schwann Cell Migration Positive Regulation Of Schwann Cell Migration	Protein Geranylgeranylation
Pathways		RND1 GTPase cycle
Drugs			L-778123 Geranylgeranyl diphosphate 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mitochondrial DNA levels ( 25240745) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Refractive error ( 32231278) Vitamin D levels ( 25208829) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Longevity ( 30294719)
Interacting Genes		33 interacting genes: ACVR1 AFDN AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB HDAC7 LGALS4 LINC00632 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAP1GDS1 RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RGL3 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6	6 interacting genes: CDC42 FNTA GNG2 KRAS RHOB RRAS2
Entrez ID		22800	5229
HPRD ID		02518	03612
Ensembl ID		ENSG00000133818	ENSG00000164219
Uniprot IDs		P62070	P53609
PDB IDs		2ERY 9B4Q 9B4S
Enriched GO Terms of Interacting Partners?		Guanyl-nucleotide Exchange Factor Activity Intracellular Signaling Cassette Signal Transduction Ras Protein Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Apoptotic Process Cytosol Regulation Of Programmed Cell Death SMAD Binding Negative Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Apoptotic Signaling Pathway Small GTPase-mediated Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Bone Mineralization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Small GTPase Binding Regulation Of Protein Modification Process Intracellular Glucose Homeostasis Enzyme-linked Receptor Protein Signaling Pathway Activin Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Response To BMP Stimulus Response To Growth Factor Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Transforming Growth Factor Beta Receptor Activity, Type I Regulation Of Cell Population Proliferation Protein Prenyltransferase Activity Apoptotic Signaling Pathway Establishment Of Endothelial Barrier Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Endothelial Cell Development	GDP Binding GTPase Activity Small GTPase-mediated Signal Transduction GTP Binding Focal Adhesion Positive Regulation Of Rac Protein Signal Transduction Regulation Of Rac Protein Signal Transduction Intracellular Signaling Cassette Signal Transduction G Protein Activity Positive Regulation Of Small GTPase Mediated Signal Transduction Plasma Membrane Peptide Pheromone Maturation Ras Protein Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility GBD Domain Binding Storage Vacuole CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Protein Farnesyltransferase Activity Protein Farnesyltransferase Complex Positive Regulation Of Locomotion Endothelin Receptor Signaling Pathway Involved In Heart Process Golgi Membrane Protein Farnesylation GMP Binding Forebrain Astrocyte Development Positive Regulation Of Schwann Cell Migration Schwann Cell Migration Nucleotide Binding Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway Rab Geranylgeranyltransferase Activity Protein Geranylgeranyltransferase Activity Response To Isolation Stress Intracellular Signal Transduction Protein Prenyltransferase Activity Protein Geranylgeranylation LRR Domain Binding Positive Regulation Of Pinocytosis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Response To Gravity Extracellular Exosome Regulation Of Cell Migration Actin Filament Organization Leading Edge Membrane Thioesterase Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?