RRAS2 and LGALS4

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RRAS2	LGALS4
Description		RAS related 2	galectin 4
Image
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Focal Adhesion Membrane Extracellular Exosome	Extracellular Space Cytosol Plasma Membrane Extracellular Matrix
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding	Protein Binding Galactoside Binding Carbohydrate Binding
	Biological Process	Osteoblast Differentiation Signal Transduction Ras Protein Signal Transduction Cell Migration Schwann Cell Migration Positive Regulation Of Schwann Cell Migration	Antibacterial Peptide Biosynthetic Process Cell Adhesion Defense Response To Bacterium
Pathways		RND1 GTPase cycle
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mitochondrial DNA levels ( 25240745) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Refractive error ( 32231278) Vitamin D levels ( 25208829) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Blood protein levels ( 30072576) Logical memory (immediate recall) in mild cognitive impairment ( 29274321)
Interacting Genes		33 interacting genes: ACVR1 AFDN AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB HDAC7 LGALS4 LINC00632 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAP1GDS1 RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RGL3 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6	18 interacting genes: ARPC3 BANP CDPF1 CEP55 EYA2 GOLGA6L9 HOMEZ HOXA1 HSF2BP KIAA1549 KRTAP11-1 MLH1 NCKIPSD OSGEP RFX6 RRAS2 TENM4 TOX2
Entrez ID		22800	3960
HPRD ID		02518	03949
Ensembl ID		ENSG00000133818	ENSG00000171747
Uniprot IDs		P62070	P56470 Q6FHZ4
PDB IDs		2ERY 9B4Q 9B4S	1X50 4XZP 4YLZ 4YM0 4YM1 4YM2 4YM3 5CBL 5DUU 5DUV 5DUW 5DUX 6WAB
Enriched GO Terms of Interacting Partners?		Guanyl-nucleotide Exchange Factor Activity Intracellular Signaling Cassette Signal Transduction Ras Protein Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Apoptotic Process Cytosol Regulation Of Programmed Cell Death SMAD Binding Negative Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Apoptotic Signaling Pathway Small GTPase-mediated Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Bone Mineralization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Small GTPase Binding Regulation Of Protein Modification Process Intracellular Glucose Homeostasis Enzyme-linked Receptor Protein Signaling Pathway Activin Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Response To BMP Stimulus Response To Growth Factor Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Transforming Growth Factor Beta Receptor Activity, Type I Regulation Of Cell Population Proliferation Protein Prenyltransferase Activity Apoptotic Signaling Pathway Establishment Of Endothelial Barrier Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Endothelial Cell Development
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