PCSK7 and HNRNPD

Number of citations of the paper that reports this interaction (PMID 11051545)
81

Data Source:
HPRD (in vivo)

		PCSK7	HNRNPD
Gene Name		proprotein convertase subtilisin/kexin type 7	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Golgi Membrane	Nucleus Nucleoplasm Cytosol Ribonucleoprotein Complex Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity	Nucleotide Binding RNA Binding Protein Binding Telomeric DNA Binding Poly(A) RNA Binding
	Biological Process	Proteolysis Protein Processing Peptide Hormone Processing	MRNA Splicing, Via Spliceosome Transcription, DNA-templated Regulation Of Transcription, DNA-templated RNA Processing RNA Catabolic Process RNA Splicing Gene Expression Regulation Of Circadian Rhythm Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Transcription, DNA-templated Circadian Regulation Of Translation
Pathways			Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Cardiovascular disease risk factors ( 21943158) Iron status biomarkers ( 21149283)
Protein-Protein Interactions		6 interactors: CSDE1 HNRNPD HSPA5 PABPC1 PMCH SYNCRIP	92 interactors: ABCC10 ACTB ARF4 B3GAT3 BCL2 BET1L BRCA1 C1QBP CAPN1 CD81 CD97 CINP COG7 COL18A1 CSDE1 CTSB CUTA DGCR2 DHX30 EEF2 EIF4G1 ERG EXOSC4 FBXL15 FLNA GSK3B GTF3C3 GTSE1 GUK1 HBZ HDAC1 HIRA HMGA1 HNRNPC HNRNPF HNRNPH3 HNRNPK HNRNPU HSPA4 HSPB1 HSPB2 IGF2BP2 IL7R IMMP2L IMMT ING4 LDHA LSM5 MAP2K1 MAPK6 MEOX2 MPP1 MTA2 MYC NTMT1 P4HB PABPC1 PCBP1 PCBP2 PCSK7 PDLIM7 PEX10 PPOX PRDX3 PRKACA PTBP2 PYCR1 RALY RPSA SAFB SDF2 SEPT9 SF3B4 SFN SHISA5 SLC27A5 SLC3A2 SNAPC4 SNRPC SREK1 SUMO4 SYNCRIP TMEM261 TNPO1 TRN-GTT2-1 TSEN34 U2AF2 UBE2I UQCRC1 VEGFA VHL YBX1
Entrez ID		9159	3184
HPRD ID		05339	03206
Ensembl ID
Uniprot IDs		Q16549	Q14103
PDB IDs			1HD0 1HD1 1IQT 1WTB 1X0F 2Z5N
Enriched GO Terms of Interacting Partners?		Regulation Of MRNA Stability Regulation Of RNA Stability MRNA Metabolic Process RNA Catabolic Process MRNA Stabilization MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Macromolecule Catabolic Process Regulation Of Translation RNA Splicing MRNA Processing Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Translation Regulation Of Protein Folding In Endoplasmic Reticulum RNA Processing Catabolic Process Cerebellum Structural Organization Nuclear-transcribed MRNA Catabolic Process Regulation Of Cellular Protein Metabolic Process MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, No-go Decay Regulation Of Protein Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay CRD-mediated MRNA Stabilization Circadian Regulation Of Translation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process ER Overload Response Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Maintenance Of Protein Localization In Endoplasmic Reticulum Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Metabolic Process Regulation Of MRNA 3'-end Processing Cellular Response To Antibiotic Anatomical Structure Arrangement Positive Regulation Of MRNA Catabolic Process Cellular Response To Toxic Substance Cellular Response To Glucose Starvation Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Polyadenylation Cellular Response To Cytokine Stimulus Cerebellar Purkinje Cell Layer Development RNA Polyadenylation Substantia Nigra Development ER-associated Ubiquitin-dependent Protein Catabolic Process Toxin Transport Cellular Response To Interleukin-4 Response To Cytokine	MRNA Metabolic Process RNA Splicing MRNA Processing RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Heterocycle Metabolic Process Cellular Metabolic Process Gene Expression Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Posttranscriptional Regulation Of Gene Expression Metabolic Process MRNA Stabilization Response To Stress Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression CRD-mediated MRNA Stabilization Cellular Process Positive Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of MRNA Stability Regulation Of RNA Stability Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Death Positive Regulation Of Protein Export From Nucleus Nuclear-transcribed MRNA Catabolic Process Regulation Of Apoptotic Process MRNA Catabolic Process Viral Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of RNA Splicing Positive Regulation Of Cellular Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Organelle Organization Regulation Of Metabolic Process Response To Wounding Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Cell Death RNA Catabolic Process Negative Regulation Of RNA Splicing Chromatin Remodeling Positive Regulation Of Metabolic Process Positive Regulation Of Mitochondrion Organization Regulation Of Translation
Tagcloud ?		aric atherogenic atherosclerosis biracial chd close communities confidence dense discovered hazard hazards homogeneous incident insights interval ldl lipid lipoprotein loci locus lowest mellitus newly proportional quartile sdldl traits variants	abcb7 advance alas2 asxl1 bclaf1 brca1 causal cbl cd34 december deregulation disruption doi erythroid exon leu link online pathophysiology prpf8 publication rars refractory sf3b1 sideroblasts slc25a37 splicing transcript transcriptome
Tagcloud (Difference) ?		aric atherogenic atherosclerosis biracial chd close communities confidence dense discovered hazard hazards homogeneous incident insights interval ldl lipid lipoprotein loci locus lowest mellitus newly proportional quartile sdldl traits variants	abcb7 advance alas2 asxl1 bclaf1 brca1 causal cbl cd34 december deregulation disruption doi erythroid exon leu link online pathophysiology prpf8 publication rars refractory sf3b1 sideroblasts slc25a37 splicing transcript transcriptome
Tagcloud (Intersection) ?