PCSK7 and HSPA5

Number of citations of the paper that reports this interaction (PubMedID 10964928)
0

Data Source:
HPRD (in vitro, in vivo)

		PCSK7	HSPA5
Description		proprotein convertase subtilisin/kexin type 7	heat shock protein family A (Hsp70) member 5
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Trans-Golgi Network Endomembrane System Membrane	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Focal Adhesion COP9 Signalosome Cell Surface Membrane Midbody Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Nucleotide Binding Calcium Ion Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding Protein Domain Specific Binding Protein Serine/threonine Kinase Inhibitor Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ribosome Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Protein-folding Chaperone Binding Misfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Proteolysis Protein Processing Peptide Hormone Processing	Translational Initiation Protein Folding ER Overload Response Cerebellum Structural Organization Cerebellar Purkinje Cell Layer Development Substantia Nigra Development Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Post-translational Protein Targeting To Membrane, Translocation Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Ubiquitination Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Maintenance Of Protein Localization In Endoplasmic Reticulum IRE1-mediated Unfolded Protein Response PERK-mediated Unfolded Protein Response ERAD Pathway Protein Refolding Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Folding In Endoplasmic Reticulum Cellular Response To Interleukin-4 Regulation Of ATF6-mediated Unfolded Protein Response Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of PERK-mediated Unfolded Protein Response
Pathways		Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	Platelet degranulation Regulation of HSF1-mediated heat shock response ATF6 (ATF6-alpha) activates chaperones PERK regulates gene expression IRE1alpha activates chaperones ATF6 (ATF6-alpha) activates chaperone genes ATF6B (ATF6-beta) activates chaperones Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC Modulation of host responses by IFN-stimulated genes
Drugs			Antihemophilic factor, human recombinant Acetylsalicylic acid Copper Lonoctocog alfa Moroctocog alfa
Diseases
GWAS		Cardiovascular disease risk factors ( 21943158) HDL cholesterol ( 24507774 31170924) Iron status biomarkers ( 21149283) Refractive error ( 32231278) Triglyceride levels ( 26763881) Triglycerides ( 24507774)	Refractive error ( 32231278) Smoking initiation ( 33082346)
Interacting Genes		7 interacting genes: CSDE1 HNRNPD HSPA5 PABPC1 PMCH SYNCRIP TRIM54	77 interacting genes: A2M AGO4 APC APOB BAG3 BCAR1 CASP7 CDK7 CPT1A DDX24 DNAJC1 DNAJC10 DPH1 DPYSL5 EIF2AK3 ERBB2 ERCC6 ERN1 ERP29 F8 FCHSD2 FNDC3B GRIA1 HLA-C HMGB1 HSPBP1 HTR3A IGHM KRT14 KRT18 KRT8 LCT LDLR LINC01554 MATK METTL21A MTNR1A MTNR1B NDRG1 NEDD4L NRIP1 OTUD3 PARK7 PAWR PCSK7 PRDM14 PRNP PSME3 PTPN11 PTPRF RIPK4 RNF114 RNF26 RPN1 SEC61A1 SEC63 SERPINB5 SH3BP4 SIL1 SIRPA SQSTM1 SREBF2 STMN1 SUMO2 SUMO4 TCERG1 TG TMEM132A TMEM62 TRA TSHR UBE3A UBQLN4 VHL VWF XAF1 YWHAB
Entrez ID		9159	3309
HPRD ID		05339	00682
Ensembl ID		ENSG00000160613	ENSG00000044574
Uniprot IDs		Q16549	P11021 V9HWB4
PDB IDs			3IUC 3LDL 3LDN 3LDO 3LDP 5E84 5E85 5E86 5EVZ 5EX5 5EXW 5EY4 5F0X 5F1X 5F2R 6ASY 6CZ1 6DFM 6DFO 6DO2 6DWS 6ZMD 7N1R
Enriched GO Terms of Interacting Partners?		MCRD-mediated MRNA Stability Complex CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Cytoplasmic Translation Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Cytoplasmic Translation MRNA Stabilization Negative Regulation Of MRNA Catabolic Process RNA Stabilization Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Metabolic Process Positive Regulation Of Translation Regulation Of MRNA Stability Regulation Of RNA Stability CRD-mediated MRNA Stability Complex Positive Regulation Of Protein Metabolic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Catabolic Process Regulation Of Translation Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleic Acid Binding Post-transcriptional Regulation Of Gene Expression RNA Catabolic Process Regulation Of Protein Metabolic Process MRNA Binding Nucleobase-containing Compound Catabolic Process Macromolecule Catabolic Process Hepatocyte Dedifferentiation Ribonucleoprotein Complex Cellular Response To Putrescine Regulation Of Protein Folding In Endoplasmic Reticulum Type 1 Melanin-concentrating Hormone Receptor Binding Melanin-concentrating Hormone Activity Catalytic Step 2 Spliceosome Negative Regulation Of Gene Expression Cytoplasmic Stress Granule Positive Regulation Of Gene Expression Circadian Regulation Of Translation Cerebellum Structural Organization Negative Regulation Of Synaptic Transmission, Dopaminergic Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of MRNA Catabolic Process MRNA Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Negative Regulation Of RNA Metabolic Process MRNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of MRNA Metabolic Process	Macromolecule Catabolic Process Regulation Of Protein Localization Endoplasmic Reticulum Protein Metabolic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Catabolic Process Catabolic Process Protein-folding Chaperone Binding Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Negative Regulation Of Establishment Of Protein Localization Adenyl-nucleotide Exchange Factor Activity Cotranslational Protein Targeting To Membrane Molecular Sequestering Activity Proteolysis Protein Modification Process Negative Regulation Of Signaling Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Melatonin Receptor Activity Regulation Of Metabolic Process Negative Regulation Of Transport Response To Stress Regulation Of Protein Transport Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Signal Transduction Signal Transduction Immunoglobulin Binding Cupric Ion Binding Negative Regulation Of Protein Transport Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Leukocyte Activation Scaffold Protein Binding Regulation Of Type I Interferon Production Regulation Of Proteolysis Protein Folding Positive Regulation Of Transcription By RNA Polymerase I Negative Regulation Of T Cell Proliferation Positive Regulation Of Cholesterol Storage Negative Regulation Of T Cell Activation Ubiquitin-like Protein Conjugating Enzyme Binding
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