CTDP1 and UPP1

Number of citations of the paper that reports this interaction (PubMedID 12036313)
0

Data Source:
BioGRID (enzymatic study)

		CTDP1	UPP1
Description		CTD phosphatase subunit 1	uridine phosphorylase 1
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Spindle Cytoskeleton Midbody Protein-containing Complex Spindle Midzone	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	TFIIF-class Transcription Factor Complex Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Hydrolase Activity Tat Protein Binding	Catalytic Activity Uridine Phosphorylase Activity Thymidine Phosphorylase Activity Transferase Activity Glycosyltransferase Activity Pentosyltransferase Activity Identical Protein Binding Deoxyuridine Phosphorylase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Protein Dephosphorylation Exit From Mitosis Host-mediated Activation Of Viral Transcription Cell Division Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development	Nucleobase-containing Compound Metabolic Process Uridine Catabolic Process Pyrimidine Nucleotide Metabolic Process CMP Catabolic Process DCMP Catabolic Process Nucleoside Metabolic Process Nucleotide Catabolic Process Cellular Response To Glucose Starvation UMP Salvage UMP Catabolic Process DTMP Catabolic Process DUMP Catabolic Process Uridine Metabolic Process
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation	Pyrimidine salvage Pyrimidine catabolism
Drugs			5-Benzylacyclouridine
Diseases
GWAS		Adverse response to drug ( 30420678) Cerebrospinal P-tau181p levels ( 28247064) Metabolite levels ( 23823483) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 32888494) Schizophrenia ( 23212062) Smoking initiation (ever regular vs never regular) ( 30679032)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483)
Interacting Genes		41 interacting genes: AKT1 CDK7 CDK8 CDK9 CSNK2A1 CSNK2A2 CSNK2B E2F1 ELP2 ELP3 ERH GTF2F1 INTS1 INTS3 INTS6 INTS7 INTS8 MED1 MED15 MED16 MED17 MED23 MED24 MED25 MED26 MED4 MED6 MED7 MED8 NDRG2 POLR2A POLR2B PRKDC PRMT5 SNRNP70 SNRPB STK38 TCEA1 UPP1 USP7 WDR77	3 interacting genes: CRYAA CTDP1 VIM
Entrez ID		9150	7378
HPRD ID		05377	08932
Ensembl ID		ENSG00000060069	ENSG00000183696
Uniprot IDs		Q9Y5B0	B4DND0 Q16831 Q86Y75
PDB IDs		1J2X 1ONV 2K7L	3EUE 3EUF 3NBQ
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Core Mediator Complex Mediator Complex RNA Polymerase II Preinitiation Complex Assembly RNA Metabolic Process Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Nucleoplasm Nucleic Acid Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Initiation Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Protein-DNA Complex Assembly Nucleobase-containing Compound Biosynthetic Process Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Initiation Surveillance Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Elongation By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription Coregulator Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-templated Transcription Elongation Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Nuclear Vitamin D Receptor Binding DNA-templated Transcription Nuclear RNA Surveillance Positive Regulation Of Biosynthetic Process INTAC Complex RNA Surveillance DNA-templated Transcription Initiation	Structural Constituent Of Eye Lens Regulation Of Cell Growth Regulation Of Cellular Component Organization Tubulin Complex Assembly Response To UV-A Regulation Of Growth Lens Fiber Cell Morphogenesis Embryonic Eye Morphogenesis Apoptotic Process Involved In Morphogenesis Embryonic Camera-type Eye Morphogenesis Lens Morphogenesis In Camera-type Eye Supramolecular Fiber Organization Lens Fiber Cell Development Astrocyte Development Keratin Filament Binding Cellular Response To Muramyl Dipeptide Bergmann Glial Cell Differentiation Response To Muramyl Dipeptide Positive Regulation Of Collagen Biosynthetic Process Tat Protein Binding TFIIF-class Transcription Factor Complex Binding Host-mediated Activation Of Viral Transcription Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Tissue Growth RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Spindle Midzone Exit From Mitosis Protein Refolding Host-mediated Perturbation Of Viral Transcription Apoptotic Process Involved In Development Protein-containing Complex Astrocyte Differentiation Negative Regulation Of Organ Growth Regulation Of Collagen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Host-mediated Activation Of Viral Process Negative Regulation Of Cardiac Muscle Hypertrophy Lens Development In Camera-type Eye Regulation Of Collagen Metabolic Process Negative Regulation Of Striated Muscle Cell Differentiation
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