CTDP1 and STK38

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (biochemical)
HPRD (in vivo)

		CTDP1	STK38
Description		CTD phosphatase subunit 1	serine/threonine kinase 38
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Spindle Cytoskeleton Midbody Protein-containing Complex Spindle Midzone	Nucleus Chromosome Cytoplasm Cytosol Site Of Double-strand Break Glutamatergic Synapse
	Molecular Function	TFIIF-class Transcription Factor Complex Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Hydrolase Activity Tat Protein Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Cadherin Binding Metal Ion Binding Protein Serine Kinase Activity Ubiquitin-like Protein Reader Activity Histone Reader Activity UFM1-modified Protein Reader Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Protein Dephosphorylation Exit From Mitosis Host-mediated Activation Of Viral Transcription Cell Division Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development	DNA Damage Checkpoint Signaling Chromatin Organization Protein Phosphorylation DNA Damage Response Negative Regulation Of Metabolic Process Intracellular Signal Transduction Protein Modification Process Negative Regulation Of MAP Kinase Activity Postsynapse Organization
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation	RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Adverse response to drug ( 30420678) Cerebrospinal P-tau181p levels ( 28247064) Metabolite levels ( 23823483) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 32888494) Schizophrenia ( 23212062) Smoking initiation (ever regular vs never regular) ( 30679032)	Mean platelet volume ( 32888494) Subclinical trait of interstitial lung disease (basilar percentage of high attenuation areas on CT scan) ( 28521775) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		41 interacting genes: AKT1 CDK7 CDK8 CDK9 CSNK2A1 CSNK2A2 CSNK2B E2F1 ELP2 ELP3 ERH GTF2F1 INTS1 INTS3 INTS6 INTS7 INTS8 MED1 MED15 MED16 MED17 MED23 MED24 MED25 MED26 MED4 MED6 MED7 MED8 NDRG2 POLR2A POLR2B PRKDC PRMT5 SNRNP70 SNRPB STK38 TCEA1 UPP1 USP7 WDR77	16 interacting genes: BANP CALM1 CTDP1 H2AC20 H2BC21 H3C6 HERC5 HRAS MOB2 S100B SENP2 TRAF3 TRIM14 TRIM25 YWHAB YWHAZ
Entrez ID		9150	11329
HPRD ID		05377	09511
Ensembl ID		ENSG00000060069	ENSG00000112079
Uniprot IDs		Q9Y5B0	Q15208
PDB IDs		1J2X 1ONV 2K7L	1PSB 6BXI
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Core Mediator Complex Mediator Complex RNA Polymerase II Preinitiation Complex Assembly RNA Metabolic Process Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Nucleoplasm Nucleic Acid Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Initiation Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Protein-DNA Complex Assembly Nucleobase-containing Compound Biosynthetic Process Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Initiation Surveillance Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Elongation By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription Coregulator Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-templated Transcription Elongation Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Nuclear Vitamin D Receptor Binding DNA-templated Transcription Nuclear RNA Surveillance Positive Regulation Of Biosynthetic Process INTAC Complex RNA Surveillance DNA-templated Transcription Initiation	Defense Response To Other Organism Innate Immune Response Phosphoserine Residue Binding Response To Other Organism Defense Response To Symbiont Nucleus Immune Response Structural Constituent Of Chromatin Response To External Biotic Stimulus Defense Response Nucleoplasm Cadherin Binding Nucleosome Ubiquitin Protein Ligase Activity Perinuclear Region Of Cytoplasm Protein Sequestering Activity Regulation Of Synaptic Plasticity Immune System Process Negative Regulation Of Protein Localization To Nucleus Long-term Synaptic Potentiation Cytoplasm Regulation Of Neuronal Synaptic Plasticity MRNA Transcription Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity GTPase Complex Regulation Of Defense Response To Virus Ubiquitin-protein Transferase Activity Synaptic Target Recognition TFIIF-class Transcription Factor Complex Binding PKR/eIFalpha Signaling Defense Response To Virus Calcium-dependent Protein Binding Cytosol Antiviral Innate Immune Response Protein Modification Process
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