CTDP1 and MED25

Number of citations of the paper that reports this interaction (PMID 16239144)
97

Data Source:
BioGRID (pull down)

		CTDP1	MED25
Gene Name		CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1	mediator complex subunit 25
Image
Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleoplasm Cytoplasm Centrosome Spindle Actin Cytoskeleton Midbody Spindle Midzone	Nucleoplasm
	Molecular Function	DNA-directed RNA Polymerase Activity CTD Phosphatase Activity	Protein Binding Transcription Factor Binding Retinoic Acid Receptor Binding Retinoid X Receptor Binding
	Biological Process	Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Protein Dephosphorylation Exit From Mitosis Gene Expression Viral Process Positive Regulation Of Viral Transcription Cell Division	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Mediator Complex Assembly
Pathways		Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Schizophrenia ( 23212062)	Blood trace element (Se levels) ( 23720494)
Protein-Protein Interactions		42 interactors: CDK7 CDK8 CDK9 CSNK2A1 CSNK2A2 CSNK2B E2F1 ELP2 ELP3 ERH GTF2F1 HIST1H4A HIST2H2AC INTS1 INTS3 INTS6 INTS7 INTS8 MED1 MED14 MED15 MED16 MED17 MED23 MED24 MED25 MED26 MED4 MED6 MED7 MED8 NDRG2 POLR2A POLR2B PRKDC PRMT5 SNRNP70 SNRPB STK38 TCEA1 UPP1 WDR77	16 interactors: CDK8 CREBBP CTDP1 ESR1 HCFC1 MED1 MED15 MED4 MED6 MED8 MED9 NR3C1 RARA RXRA SREBF1 THRA
Entrez ID		9150	81857
HPRD ID		05377	14380
Ensembl ID		ENSG00000060069	ENSG00000104973
Uniprot IDs		Q9Y5B0	Q71SY5
PDB IDs		1J2X 1ONV 2K7L	2KY6 2L23 2L6U 2XNF
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Transcription, DNA-templated Gene Expression RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Androgen Receptor Signaling Pathway Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression DNA-templated Transcription, Elongation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Gene Expression Regulation Of Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Viral Transcription NcRNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process SnRNA Processing Regulation Of Viral Transcription Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Process Stem Cell Maintenance SnRNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Checkpoint MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Stem Cell Development Positive Regulation Of Metabolic Process 7-methylguanosine MRNA Capping Regulation Of Viral Process	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Metabolic Process Hormone-mediated Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Metabolic Process Cellular Response To Lipid Steroid Hormone Mediated Signaling Pathway Regulation Of Metabolic Process Response To Steroid Hormone Cellular Response To Hormone Stimulus Cellular Response To Organic Cyclic Compound Negative Regulation Of Transcription From RNA Polymerase II Promoter Steroid Metabolic Process Gland Development Response To Lipid Negative Regulation Of Gene Expression Response To Organic Cyclic Compound Response To Hormone Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Negative Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		13q14 18qtel 1p32 3p14 3q21 4q11 4q24 5p13 5p15 5ptel 8p23 9qtel c84c11 cgh d1s427 d5s23 d8s504 d9s325 dab2 dxs7132 faf1 fhit genosensor imbalances q12 rbp1 rbp2 shgc xq12	allelic appreciated approximate carrying complementing constrained constraint constructs flowering hypomorphic implies interrupted lengths minuscule occupied pft1 phenocopied photoperiod polyglutamine pursuant stark str strs thaliana traits transgene underlies undescribed varying
Tagcloud (Difference) ?		13q14 18qtel 1p32 3p14 3q21 4q11 4q24 5p13 5p15 5ptel 8p23 9qtel c84c11 cgh d1s427 d5s23 d8s504 d9s325 dab2 dxs7132 faf1 fhit genosensor imbalances q12 rbp1 rbp2 shgc xq12	allelic appreciated approximate carrying complementing constrained constraint constructs flowering hypomorphic implies interrupted lengths minuscule occupied pft1 phenocopied photoperiod polyglutamine pursuant stark str strs thaliana traits transgene underlies undescribed varying
Tagcloud (Intersection) ?