MXI1 and PEAR1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		MXI1	PEAR1
Name		MAX interactor 1, dimerization protein	platelet endothelial aggregation receptor 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytosol RNA Polymerase II Transcription Regulator Complex	Phagocytic Cup Plasma Membrane Membrane Lamellipodium Cell Projection
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity	Protein Binding Signaling Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Formation Regulation Of Transcription By RNA Polymerase II	Positive Regulation Of Platelet Activation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Recognition Of Apoptotic Cell Platelet Aggregation
GWAS		Birth weight ( 31043758 ) Cutaneous malignant melanoma ( 32341527 ) Diastolic blood pressure ( 30224653 ) Neutrophil count ( 29403010 32888494 ) Normalized brain volume ( 19010793 ) Platelet count ( 29403010 ) Refractive error ( 32231278 ) White blood cell count ( 29403010 32888494 )	Blood protein levels ( 30072576 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Mean platelet volume ( 27863252 32888494 ) Platelet aggregation ( 20526338 29185836 ) Platelet count ( 29403010 32888494 ) Platelet distribution width ( 27863252 32888494 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )
Interacting Genes		30 interacting genes: APP CALCOCO2 CYSRT1 EFEMP2 ENTPD5 KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP5-7 MAX MDFI MYC NBPF19 NOTCH2NLA PEAR1 PRMT5 RPL23AP32 SIN3A SIN3B SMARCB1 SMC3 UBE2O USHBP1 ZNF655	3 interacting genes: KRTAP4-5 MXI1 NUFIP2
Entrez ID		4601	375033
HPRD ID		02486	18957
Ensembl ID		ENSG00000119950	ENSG00000187800
Uniprot IDs		A0A0S2Z3X5 P50539	Q5VY43
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Keratin Filament Intermediate Filament Myc-Max Complex Epigenetic Regulation Of Gene Expression Structural Constituent Of Skin Epidermis E-box Binding Regulation Of Stem Cell Population Maintenance Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation XY Body	None