MXI1 and MAX

Number of citations of the paper that reports this interaction (PMID 15121849)
33

Data Source:
HPRD (in vitro)

		MXI1	MAX
Gene Name		MAX interactor 1, dimerization protein	MYC associated factor X
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm	Nucleus Nucleoplasm Cytoplasm PML Body Dendrite MLL1 Complex
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Dimerization Activity	Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Transcription Coactivator Activity Protein Binding Protein Complex Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Cell Proliferation Cytoplasmic Sequestering Of Transcription Factor	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Protein Complex Assembly Cellular Response To Starvation Negative Regulation Of Gene Expression Response To Insulin Response To Axon Injury Neuron Apoptotic Process Retina Development In Camera-type Eye Cellular Response To Peptide Hormone Stimulus
Pathways			G1/S Transition Cyclin E associated events during G1/S transition S Phase Cyclin A:Cdk2-associated events at S phase entry Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Normalized brain volume ( 19010793)	Anthropometric traits ( 19260139) Blood trace element (Zn levels) ( 23720494) Obesity-related traits ( 23251661) Red blood cell traits ( 23222517)
Protein-Protein Interactions		16 interactors: APP CALCOCO2 ENTPD5 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 MAX MYC NOTCH2NL RPL23AP32 SIN3A SIN3B SMC3	43 interactors: BANP CASP5 CASP7 CLIP2 COPS5 CSNK2A1 CUX1 EP300 EPAS1 FTH1 FUS GABBR1 HIF1A MAD1L1 MAPK14 MGA MNT MSH2 MXD1 MXD3 MXD4 MXI1 MYC MYCL MYCLP1 MYCN PLEKHA5 PLEKHF2 PLIN3 RPL34 RPL35 SMAD3 SMAD4 SNIP1 SPAG9 TAF1 TCF3 TEAD1 TRRAP TUBA1A TXLNG UNC45A ZBTB17
Entrez ID		4601	4149
HPRD ID		02486	01113
Ensembl ID		ENSG00000119950	ENSG00000125952
Uniprot IDs		B1ANN8 P50539	P61244 Q8TAX8
PDB IDs			1AN2 1HLO 1NKP 1NLW 1R05
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Transcription From RNA Polymerase II Promoter Neuron Apoptotic Process Regulation Of Cell Cycle Nucleobase-containing Compound Metabolic Process Histone Deacetylation Neuron Death Protein Deacetylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Chromosome Organization Response To Methylglyoxal Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Negative Regulation Of Histone H3-K27 Acetylation Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Stress Regulation Of Cell Cycle Process Synaptic Growth At Neuromuscular Junction Fibroblast Apoptotic Process Positive Regulation Of Mitotic Cell Cycle Developmental Process Nitrogen Compound Metabolic Process Cellular Chemical Homeostasis Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Collateral Sprouting In Absence Of Injury Positive Regulation Of Chromatin Silencing Chromatin Modification Positive Regulation Of Peptidase Activity Cell Growth Transition Metal Ion Homeostasis Cellular Response To Stress Cellular Homeostasis Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of DNA Endoreduplication Response To Wounding Chromatin Organization Negative Regulation Of Cell Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Monocyte Differentiation Axon Choice Point Recognition Positive Regulation Of Cell Proliferation Involved In Kidney Development	RNA Biosynthetic Process RNA Metabolic Process Gene Expression Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Gene Expression Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transforming Growth Factor Beta2 Production Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Catabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Tube Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Negative Regulation Of Cell Division Multicellular Organismal Development Negative Regulation Of Cell Cycle Transcription Initiation From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Embryo Development Positive Regulation Of Cell Development Regulation Of Cellular Process Cellular Metabolic Process
Tagcloud ?		acting antagonizes b1 believed cdc2 cdk2 classic declined dramatically g2 glomerulonephritis gradually interactor inversely ki67 max mentioned mesangial myc nephritis obvious opposite percentage plasmid proliferation proliferative sirna thy1 transfection	aminoiminomethyl behaves competitive dichloro dimethylquinolin displaced giving henyl int ips lf m1 muscarinic nonpeptide oxymethyl pa2 phenylcarbonyl phosphoinositosides piperazin plot pyrrolidine rbonyl saturation schild shifted slope sulphonyl umbilical unity yl
Tagcloud (Difference) ?		acting antagonizes b1 believed cdc2 cdk2 classic declined dramatically g2 glomerulonephritis gradually interactor inversely ki67 max mentioned mesangial myc nephritis obvious opposite percentage plasmid proliferation proliferative sirna thy1 transfection	aminoiminomethyl behaves competitive dichloro dimethylquinolin displaced giving henyl int ips lf m1 muscarinic nonpeptide oxymethyl pa2 phenylcarbonyl phosphoinositosides piperazin plot pyrrolidine rbonyl saturation schild shifted slope sulphonyl umbilical unity yl
Tagcloud (Intersection) ?