GNAL

Description		G protein subunit alpha L
Image
GO Annotations	Cellular Component	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Adenylate Cyclase Regulator Activity Hydrolase Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Response To Amphetamine Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Chemical Stimulus Sensory Perception Of Smell Response To Caffeine
Pathways		Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Olfactory Signaling Pathway Olfactory Signaling Pathway
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 27089180) Alcohol dependence ( 26365420) Metabolite levels ( 23823483) QT interval (drug interaction) ( 23459443) Sensation seeking ( 30718321) Tandem gait ( 26219847) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Novel Interacting Genes		6 novel interacting genes: DOCK2 KCNH3 MIF TAF3 USP8 WASL
Interacting Genes
Entrez ID		2774
HPRD ID		00758
Ensembl ID		ENSG00000141404
Uniprot IDs		A8K1Y9 P38405
PDB IDs		8EL8 8IW1 8KGK 8KH4
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Leukocyte Migration Negative Regulation Of Mononuclear Cell Migration Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Endocytosis Membrane Raft Polarization Myeloid Dendritic Cell Activation Involved In Immune Response Regulation Of Mononuclear Cell Migration Phenylpyruvate Tautomerase Activity Positive Regulation Of Arachidonate Secretion Positive Regulation Of Prostaglandin Secretion Involved In Immune Response Regulation Of Signal Transduction By P53 Class Mediator Dopachrome Isomerase Activity Negative Regulation Of Mature B Cell Apoptotic Process Negative Regulation Of Membrane Tubulation Positive Regulation Of Clathrin-dependent Endocytosis Actin Cap Negative Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Positive T Cell Selection Positive Regulation Of Cellular Component Organization Membrane Raft Distribution Positive Thymic T Cell Selection T Cell Receptor Binding Positive Regulation Of Transport Locomotion Immunological Synapse Formation Small GTPase-mediated Signal Transduction Alpha-beta T Cell Proliferation Actin Cytoskeleton Organization Pinocytosis Macropinocytosis Negative Thymic T Cell Selection Negative T Cell Selection Membrane Raft Localization Plasma Membrane Chemotaxis Regulation Of Endocytosis Establishment Of T Cell Polarity Regulation Of Leukocyte Migration Prostaglandin Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Prostanoid Biosynthetic Process Regulation Of Arachidonate Secretion Negative Regulation Of B Cell Apoptotic Process Negative Regulation Of Macrophage Migration Positive Regulation Of Icosanoid Secretion Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Macrophage Chemotaxis Protein Homotrimerization
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