GNAL and WASL

Data Source: HiPPIP (Novel)

		GNAL	WASL
Name		G protein subunit alpha L	WASP like actin nucleation promoting factor
Structure
GO Annotations	Cellular Component	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Membrane Extracellular Exosome	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Lamellipodium Actin Cap Endocytic Vesicle Membrane Cytoplasmic Vesicle Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Adenylate Cyclase Regulator Activity Hydrolase Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	Actin Binding Protein Binding GTPase Regulator Activity
	Biological Process	Response To Amphetamine Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Chemical Stimulus Sensory Perception Of Smell Response To Caffeine	Vesicle Budding From Membrane Actin Filament Organization Actin Polymerization Or Depolymerization Response To Bacterium Vesicle Organization Actin Cytoskeleton Organization Actin Filament Polymerization Vesicle Transport Along Actin Filament Protein-containing Complex Localization Regulation Of Protein Localization Positive Regulation Of Transcription By RNA Polymerase II Cell Division Positive Regulation Of Filopodium Assembly Spindle Localization Dendritic Spine Morphogenesis Protein-containing Complex Assembly Regulation Of Postsynapse Organization Negative Regulation Of Membrane Tubulation Positive Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of Lymphocyte Migration
Pathways		Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Olfactory Signaling Pathway Olfactory Signaling Pathway	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation NOSTRIN mediated eNOS trafficking Nephrin family interactions EPHB-mediated forward signaling EPHB-mediated forward signaling DCC mediated attractive signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOV GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
GWAS		Age at first sexual intercourse ( 27089180 ) Alcohol dependence ( 26365420 ) Metabolite levels ( 23823483 ) QT interval (drug interaction) ( 23459443 ) Sensation seeking ( 30718321 ) Tandem gait ( 26219847 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 )	High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Platelet count ( 22139419 27863252 ) Plateletcrit ( 27863252 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 )
Novel Interactors		6 novel interactors: DOCK2 KCNH3 MIF TAF3 USP8 WASL	2 novel interactors: AASS GNAL
Interacting Genes		None recorded	62 interacting genes: ABI2 ABL1 ACTG1 ACTR2 ACTR3 APBB1 APP ARPC3 ARPC4 BIN1 CDC42 CORO7 CTTN DNMBP EGFR EVL FCHSD2 FNBP1 FNBP1L GRB2 HP HSP90AA1 HSP90AB1 IPO5 ITCH ITGB1BP2 ITSN1 ITSN2 LCK NCK1 NCK2 NCKIPSD OSTF1 PACSIN1 PACSIN2 PACSIN3 PFN1 PRMT2 PRPF40A PSTPIP1 PTK6 RHOQ RIPPLY3 RNF8 RPL7AP66 SDCBP SH3GL3 SH3RF1 SNX9 SORBS2 SRC TNNT3 TRIP10 UBASH3A UBASH3B VASP VIPR1 WIPF1 WIPF2 WIPF3 WWP1 ZNF395
Entrez ID		2774	8976
HPRD ID		00758	05448
Ensembl ID		ENSG00000141404	ENSG00000106299
Uniprot IDs		A8K1Y9 P38405	O00401
PDB IDs		8EL8 8IW1 8KGK 8KH4	2FF3 2LNH 2VCP 4CC2 4CC7 9DLX
GO Terms Enriched among Interactors		Negative Regulation Of Leukocyte Migration Negative Regulation Of Mononuclear Cell Migration Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Endocytosis Membrane Raft Polarization Myeloid Dendritic Cell Activation Involved In Immune Response Regulation Of Mononuclear Cell Migration Phenylpyruvate Tautomerase Activity Positive Regulation Of Arachidonate Secretion Positive Regulation Of Prostaglandin Secretion Involved In Immune Response Regulation Of Signal Transduction By P53 Class Mediator Dopachrome Isomerase Activity Negative Regulation Of Mature B Cell Apoptotic Process Negative Regulation Of Membrane Tubulation Positive Regulation Of Clathrin-dependent Endocytosis Actin Cap Negative Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Positive T Cell Selection Positive Regulation Of Cellular Component Organization Membrane Raft Distribution Positive Thymic T Cell Selection T Cell Receptor Binding Positive Regulation Of Transport Locomotion Immunological Synapse Formation Small GTPase-mediated Signal Transduction Alpha-beta T Cell Proliferation Actin Cytoskeleton Organization Pinocytosis Macropinocytosis Negative Thymic T Cell Selection Negative T Cell Selection Membrane Raft Localization Plasma Membrane Chemotaxis Regulation Of Endocytosis Establishment Of T Cell Polarity Regulation Of Leukocyte Migration Prostaglandin Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Prostanoid Biosynthetic Process Regulation Of Arachidonate Secretion Negative Regulation Of B Cell Apoptotic Process Negative Regulation Of Macrophage Migration Positive Regulation Of Icosanoid Secretion Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Macrophage Chemotaxis Protein Homotrimerization	Endocytosis Actin Filament Organization Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Actin Filament Polymerization Import Into Cell Positive Regulation Of Cellular Component Organization Supramolecular Fiber Organization Cytoplasm Cytosol Positive Regulation Of Protein Polymerization Regulation Of Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Cellular Component Organization Profilin Binding Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Polymerization Actin Filament-based Process Positive Regulation Of Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Endocytosis Positive Regulation Of Protein-containing Complex Assembly Vesicle-mediated Transport Regulation Of Cell Projection Organization Cytoskeleton Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Organelle Organization Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Lamellipodium Regulation Of Cellular Component Size Cytoskeletal Anchor Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Projection Focal Adhesion Regulation Of Cell Projection Assembly Cytoskeleton Plasma Membrane Tubulation Actin Polymerization Or Depolymerization Positive Regulation Of Lamellipodium Organization Proline-rich Region Binding Arp2/3 Complex-mediated Actin Nucleation Extracellular Exosome SH3 Domain Binding Regulation Of Vesicle-mediated Transport Actin Binding Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly