GNAL and MIF

Data Source: HiPPIP (Novel)

		GNAL	MIF
Name		G protein subunit alpha L	macrophage migration inhibitory factor
Structure
GO Annotations	Cellular Component	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Membrane Extracellular Exosome	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Surface Vesicle Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Adenylate Cyclase Regulator Activity Hydrolase Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	Protease Binding Dopachrome Isomerase Activity Cytokine Activity Cytokine Receptor Binding Protein Binding Isomerase Activity Chemoattractant Activity Identical Protein Binding Phenylpyruvate Tautomerase Activity
	Biological Process	Response To Amphetamine Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Chemical Stimulus Sensory Perception Of Smell Response To Caffeine	Prostaglandin Biosynthetic Process Positive Regulation Of Cytokine Production Immune System Process Negative Regulation Of Mature B Cell Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Macrophage Chemotaxis Carboxylic Acid Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Myeloid Cell Apoptotic Process Regulation Of Cell Population Proliferation Positive Regulation Of Phosphorylation Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Innate Immune Response Positive Regulation Of Fibroblast Proliferation Positive Chemotaxis Negative Regulation Of Protein Metabolic Process Positive Regulation Of Prostaglandin Secretion Involved In Immune Response Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Protein Homotrimerization Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cellular Response To Stress Positive Regulation Of Arachidonate Secretion Cellular Senescence Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Cellular Senescence
Pathways		Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Olfactory Signaling Pathway Olfactory Signaling Pathway	Cell surface interactions at the vascular wall Neutrophil degranulation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		None	3,4-Dihydroxycinnamic Acid 7-Hydroxy-2-Oxo-Chromene-3-Carboxylic Acid Ethyl Ester 4-Hydroxyphenylpyruvic acid 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIME 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE
GWAS		Age at first sexual intercourse ( 27089180 ) Alcohol dependence ( 26365420 ) Metabolite levels ( 23823483 ) QT interval (drug interaction) ( 23459443 ) Sensation seeking ( 30718321 ) Tandem gait ( 26219847 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 )	Alanine aminotransferase levels ( 33547301 ) Blood protein levels ( 30072576 ) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 ) Macrophage Migration Inhibitory Factor levels ( 27989323 ) Serum alkaline phosphatase levels ( 33547301 )
Novel Interactors		6 novel interactors: DOCK2 KCNH3 MIF TAF3 USP8 WASL	2 novel interactors: FCER1G GNAL
Interacting Genes		None recorded	15 interacting genes: BEX3 BNIPL CD74 CEBPA COPS5 COPS6 EGFR EXOSC7 GORASP2 NME1 NTAQ1 STRN4 TP53 UPF2 ZNF408
Entrez ID		2774	4282
HPRD ID		00758	01091
Ensembl ID		ENSG00000141404	ENSG00000240972
Uniprot IDs		A8K1Y9 P38405	I4AY87 P14174
PDB IDs		8EL8 8IW1 8KGK 8KH4	1CA7 1CGQ 1GCZ 1GD0 1GIF 1LJT 1MIF 1P1G 2OOH 2OOW 2OOZ 3B9S 3CE4 3DJH 3DJI 3HOF 3IJG 3IJJ 3JSF 3JSG 3JTU 3L5P 3L5R 3L5S 3L5T 3L5U 3L5V 3SMB 3SMC 3U18 3WNR 3WNS 3WNT 4ETG 4EUI 4EVG 4F2K 4GRN 4GRO 4GRP 4GRQ 4GRR 4GRU 4GUM 4K9G 4OSF 4OYQ 4P01 4P0H 4PKK 4PKZ 4PLU 4TRF 4TRU 4WR8 4WRB 4XX7 4XX8 4Z15 4Z1T 4Z1U 5B4O 5BS9 5BSC 5BSI 5BSJ 5EIZ 5HVS 5HVT 5HVV 5J7P 5J7Q 5UMJ 5UMK 5UZY 5V70 5V73 5XEJ 6B1C 6B1K 6B2C 6BG6 6BG7 6CB5 6CBF 6CBG 6CBH 6FVE 6FVH 6OY8 6OYB 6OYE 6OYG 6PEG 7E45 7E47 7E49 7E4A 7E4B 7E4C 7KQX 7XTX 7XVX 8CA0 8IMR 8SON 8SPN 8TT9 9BNQ 9BNR
GO Terms Enriched among Interactors		Negative Regulation Of Leukocyte Migration Negative Regulation Of Mononuclear Cell Migration Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Endocytosis Membrane Raft Polarization Myeloid Dendritic Cell Activation Involved In Immune Response Regulation Of Mononuclear Cell Migration Phenylpyruvate Tautomerase Activity Positive Regulation Of Arachidonate Secretion Positive Regulation Of Prostaglandin Secretion Involved In Immune Response Regulation Of Signal Transduction By P53 Class Mediator Dopachrome Isomerase Activity Negative Regulation Of Mature B Cell Apoptotic Process Negative Regulation Of Membrane Tubulation Positive Regulation Of Clathrin-dependent Endocytosis Actin Cap Negative Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Positive T Cell Selection Positive Regulation Of Cellular Component Organization Membrane Raft Distribution Positive Thymic T Cell Selection T Cell Receptor Binding Positive Regulation Of Transport Locomotion Immunological Synapse Formation Small GTPase-mediated Signal Transduction Alpha-beta T Cell Proliferation Actin Cytoskeleton Organization Pinocytosis Macropinocytosis Negative Thymic T Cell Selection Negative T Cell Selection Membrane Raft Localization Plasma Membrane Chemotaxis Regulation Of Endocytosis Establishment Of T Cell Polarity Regulation Of Leukocyte Migration Prostaglandin Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Prostanoid Biosynthetic Process Regulation Of Arachidonate Secretion Negative Regulation Of B Cell Apoptotic Process Negative Regulation Of Macrophage Migration Positive Regulation Of Icosanoid Secretion Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Macrophage Chemotaxis Protein Homotrimerization	Macrophage Migration Inhibitory Factor Binding Identical Protein Binding T Cell Activation Involved In Immune Response Protein Deneddylation Metal-dependent Deubiquitinase Activity Regulation Of Fibroblast Proliferation Regulation Of Protein Neddylation Protein Neddylation Regulation Of Fatty Acid Biosynthetic Process Cytokine-mediated Signaling Pathway MHC Class II Protein Binding, Via Antigen Binding Groove Lymphocyte Activation Involved In Immune Response NOS2-CD74 Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Macrophage Migration Inhibitory Factor Signaling Pathway Cell Activation Involved In Immune Response Regulation Of Protein Modification Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Protein Metabolic Process Antigen Processing And Presentation Of Exogenous Antigen Leukocyte Activation Involved In Immune Response B Cell Mediated Immunity Protein-containing Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immunoglobulin Mediated Immune Response Negative Regulation Of Stem Cell Proliferation Embryonic Organ Development Embryonic Placenta Development RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Multivesicular Body, Internal Vesicle Lumen Leukocyte Apoptotic Process IgE Receptor Activity Farnesyl Diphosphate Kinase Activity Succinyl-CoA Binding Protein Phosphatase 2A Binding Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition COP9 Signalosome Protein-N-terminal Glutamine Amidohydrolase Activity Nucleus Negative Regulation Of Apoptotic Process Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Fibroblast Proliferation Regulation Of Lymphocyte Apoptotic Process Protein Complex Oligomerization Regulation Of Apoptotic Process