IL27RA and GALNT15

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IL27RA	GALNT15
Description		interleukin 27 receptor subunit alpha	polypeptide N-acetylgalactosaminyltransferase 15
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Golgi Membrane Golgi Apparatus Membrane Transport Vesicle
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Interleukin-27 Receptor Activity	Polypeptide N-acetylgalactosaminyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Carbohydrate Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Cellular Extravasation Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Immune Response Cell Surface Receptor Signaling Pathway Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Type II Interferon Production Negative Regulation Of Neuron Apoptotic Process Regulation Of Isotype Switching To IgG Isotypes Defense Response To Gram-positive Bacterium Interleukin-27-mediated Signaling Pathway Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T Cell Extravasation	Protein Glycosylation Protein O-linked Glycosylation Protein O-linked Glycosylation Via N-acetyl-galactosamine
Pathways		Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling	O-linked glycosylation of mucins
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)	Numerical cognitive ability ( 31620175) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		11 interacting genes: CLDN2 DEFB121 DERL3 EBI3 GALNT15 IL27 MAPK8 SLC41A2 SLC61A1 STAT1 YIPF6	18 interacting genes: CD200R1 CD79A CISD2 EVI2B FCRL6 FFAR2 FNDC9 GOLM1 IL27RA MR1 MUC1 PDCD1LG2 PDZK1IP1 SLC30A2 SLC7A1 SPSB2 SYNPR TMEM179B
Entrez ID		9466	117248
HPRD ID		09247	13563
Ensembl ID		ENSG00000104998	ENSG00000131386
Uniprot IDs		Q6UWB1	C9JGI4 Q4G146 Q8N3T1
PDB IDs		7T5M 7U7N 8D85
Enriched GO Terms of Interacting Partners?		Interleukin-27 Receptor Binding JUN Phosphorylation Response To Stress Positive Regulation Of Defense Response To Virus By Host Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Regulation Of Defense Response To Virus By Host Response To Metformin Cytokine Activity Molybdate Ion Transmembrane Transporter Activity Molybdate Ion Transport Response To External Biotic Stimulus Energy Homeostasis Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Defense Response To Virus Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Intestinal D-glucose Absorption Positive Regulation Of Type II Interferon Production Nickel Cation Transport	Membrane Plasma Membrane External Side Of Plasma Membrane Negative Regulation Of T Cell Migration Positive Regulation Of Immune System Process Regulation Of Immune System Process Negative Regulation Of Lymphocyte Migration Immune Response Positive Regulation Of Neutrophil Differentiation Positive Regulation Of T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Negative Regulation Of T Cell Extravasation Negative Regulation Of Mononuclear Cell Migration Regulation Of T Cell Migration Negative Regulation Of Interleukin-6 Production Transmembrane Signaling Receptor Activity Negative Regulation Of Leukocyte Migration
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