IL27RA and EBI3

Number of citations of the paper that reports this interaction (PMID 12121660)
208

Data Source:
HPRD (in vitro, in vivo)

		IL27RA	EBI3
Gene Name		interleukin 27 receptor, alpha	Epstein-Barr virus induced 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane	Extracellular Space Plasma Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Interleukin-27 Receptor Activity	Cytokine Receptor Activity Cytokine Activity Protein Binding Interleukin-27 Receptor Binding
	Biological Process	Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Interferon-gamma Production Regulation Of Isotype Switching To IgG Isotypes Defense Response To Gram-positive Bacterium Interleukin-27-mediated Signaling Pathway	Humoral Immune Response Cytokine-mediated Signaling Pathway T-helper 1 Type Immune Response Positive Regulation Of Interferon-gamma Biosynthetic Process Positive Regulation Of Alpha-beta T Cell Proliferation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: EBI3 IL27 MAPK8 STAT1	6 interactors: CANX GOSR1 IL12A IL27RA MDFI SMAD3
Entrez ID		9466	10148
HPRD ID		09247	12051
Ensembl ID		ENSG00000104998	ENSG00000105246
Uniprot IDs		Q6UWB1	Q14213
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interferon-gamma Biosynthetic Process Immune Response Regulation Of Immune System Process Positive Regulation Of Interferon-gamma Production Response To Bacterium Positive Regulation Of Cytokine Biosynthetic Process Immune System Process Regulation Of Interferon-gamma Production Response To Other Organism Response To Biotic Stimulus Regulation Of Cytokine Biosynthetic Process Innate Immune Response Response To Hydrogen Peroxide Negative Regulation Of Macrophage Fusion Regulation Of Immune Response Regulation Of T Cell Proliferation Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Response To Reactive Oxygen Species Positive Regulation Of Metabolic Process Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Response To Mechanical Stimulus Regulation Of Innate Immune Response Defense Response JUN Phosphorylation Metanephric Mesenchymal Cell Differentiation Regulation Of T Cell Activation Positive Regulation Of Deacetylase Activity Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Response To Lipopolysaccharide Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Response To Molecule Of Bacterial Origin Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Determination Of Dorsal Identity Positive Regulation Of Cytokine Production Regulation Of Cell-cell Adhesion Mesenchymal Cell Differentiation Involved In Kidney Development Regulation Of Lymphocyte Activation Response To External Stimulus Regulation Of T-helper 1 Cell Differentiation Cell Proliferation Involved In Metanephros Development Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Cellular Response To Lipid Response To Oxidative Stress	Positive Regulation Of Cytokine Production Positive Regulation Of Interferon-gamma Production Defense Response To Gram-positive Bacterium Regulation Of Interferon-gamma Production Regulation Of Transcription Factor Import Into Nucleus Regulation Of Cytokine Production Positive Regulation Of Transforming Growth Factor Beta3 Production Extrinsic Apoptotic Signaling Pathway Embryonic Skeletal System Morphogenesis Interleukin-27-mediated Signaling Pathway Response To Other Organism Cell Cycle Arrest Response To Biotic Stimulus Positive Regulation Of Adaptive Immune Response Embryonic Skeletal System Development Evasion Or Tolerance Of Host Defenses By Virus Regulation Of Protein Import Into Nucleus Immune System Process Regulation Of Immune Response Defense Response To Bacterium Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Regulation Of Adaptive Immune Response Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Regulation Of Extracellular Matrix Assembly Positive Regulation Of NK T Cell Activation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Primary MiRNA Processing Regulation Of Protein Phosphorylation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Regulation Of Binding Regulation Of Intracellular Protein Transport Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Osteoblast Proliferation SMAD Protein Complex Assembly Skeletal System Morphogenesis Positive Regulation Of Immune Response To Tumor Cell Regulation Of Transforming Growth Factor Beta2 Production Transdifferentiation Regulation Of Isotype Switching To IgG Isotypes Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Catenin Import Into Nucleus Embryonic Organ Morphogenesis Positive Regulation Of Signal Transduction Negative Regulation Of Interleukin-17 Production Positive Regulation Of Alkaline Phosphatase Activity
Tagcloud ?		alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1	c57bl cd25 cd28 cd3 cd4 cd8 ctla cytometry distinguishing draining foxp3 helios herein neuropilin nodes nrp1 pdlns peripherally proportion ptreg reliable seems spleen stimulating thymic thymus treg ttreg younger
Tagcloud (Difference) ?		alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1	c57bl cd25 cd28 cd3 cd4 cd8 ctla cytometry distinguishing draining foxp3 helios herein neuropilin nodes nrp1 pdlns peripherally proportion ptreg reliable seems spleen stimulating thymic thymus treg ttreg younger
Tagcloud (Intersection) ?