IL27RA and EBI3

Number of citations of the paper that reports this interaction (PubMedID 12121660)
0

Data Source:
HPRD (in vivo, in vitro)

		IL27RA	EBI3
Description		interleukin 27 receptor subunit alpha	Epstein-Barr virus induced 3
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Interleukin-27 Receptor Activity	Cytokine Receptor Activity Cytokine Activity Protein Binding Interleukin-27 Receptor Binding
	Biological Process	Negative Regulation Of Cellular Extravasation Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Immune Response Cell Surface Receptor Signaling Pathway Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Type II Interferon Production Negative Regulation Of Neuron Apoptotic Process Regulation Of Isotype Switching To IgG Isotypes Defense Response To Gram-positive Bacterium Interleukin-27-mediated Signaling Pathway Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T Cell Extravasation	Immune System Process Humoral Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Positive Regulation Of Type II Interferon Production T-helper 1 Type Immune Response T Cell Proliferation Positive Regulation Of Alpha-beta T Cell Proliferation
Pathways		Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling	Interleukin-35 Signalling Interleukin-27 signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)	Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Triglyceride levels ( 32154731)
Interacting Genes		11 interacting genes: CLDN2 DEFB121 DERL3 EBI3 GALNT15 IL27 MAPK8 SLC41A2 SLC61A1 STAT1 YIPF6	9 interacting genes: CANX GOSR1 IL12A IL27RA MDFI S100A6 S100P SMAD3 UBC
Entrez ID		9466	10148
HPRD ID		09247	12051
Ensembl ID		ENSG00000104998	ENSG00000105246
Uniprot IDs		Q6UWB1	Q14213
PDB IDs		7T5M 7U7N 8D85	7U7N 7ZXK 8D85 8XWY
Enriched GO Terms of Interacting Partners?		Interleukin-27 Receptor Binding JUN Phosphorylation Response To Stress Positive Regulation Of Defense Response To Virus By Host Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Regulation Of Defense Response To Virus By Host Response To Metformin Cytokine Activity Molybdate Ion Transmembrane Transporter Activity Molybdate Ion Transport Response To External Biotic Stimulus Energy Homeostasis Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Defense Response To Virus Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Intestinal D-glucose Absorption Positive Regulation Of Type II Interferon Production Nickel Cation Transport	Negative Regulation Of Interleukin-17 Production
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