IL27RA and SLC61A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IL27RA	SLC61A1
Description		interleukin 27 receptor subunit alpha	solute carrier family 61 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Interleukin-27 Receptor Activity	Protein Binding Molybdate Ion Transmembrane Transporter Activity
	Biological Process	Negative Regulation Of Cellular Extravasation Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Immune Response Cell Surface Receptor Signaling Pathway Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Type II Interferon Production Negative Regulation Of Neuron Apoptotic Process Regulation Of Isotype Switching To IgG Isotypes Defense Response To Gram-positive Bacterium Interleukin-27-mediated Signaling Pathway Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T Cell Extravasation	Monoatomic Ion Transport Molybdate Ion Transport Response To Food Response To Starvation
Pathways		Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		11 interacting genes: CLDN2 DEFB121 DERL3 EBI3 GALNT15 IL27 MAPK8 SLC41A2 SLC61A1 STAT1 YIPF6	58 interacting genes: ADGRE2 AQP6 ARL6IP1 BEST2 BLCAP BTNL9 C2CD2L CBARP CCL4L2 CD40 CD79A CLDN7 CLRN1 CREB3 CREB3L1 ERRFI1 FFAR2 FXYD3 GJA5 GLP1R GOSR2 GPR101 GPR152 GPR25 GPR42 GPX8 HSD17B13 IGFBP5 IL27RA KASH5 LAT LHFPL5 LMNA MMGT1 MUC1 PEX19 PKMYT1 PLN RNF144A RNF19B RTP2 SCN3B SHISAL1 SLC10A6 SLC18A2 SLC39A9 SSMEM1 STATH TBXA2R TIMMDC1 TMEM128 TMEM130 TMEM14B TMEM179B TMEM203 TMEM237 XRN1 YIPF6
Entrez ID		9466	84975
HPRD ID		09247	14416
Ensembl ID		ENSG00000104998	ENSG00000182544
Uniprot IDs		Q6UWB1	Q6N075
PDB IDs		7T5M 7U7N 8D85
Enriched GO Terms of Interacting Partners?		Interleukin-27 Receptor Binding JUN Phosphorylation Response To Stress Positive Regulation Of Defense Response To Virus By Host Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Regulation Of Defense Response To Virus By Host Response To Metformin Cytokine Activity Molybdate Ion Transmembrane Transporter Activity Molybdate Ion Transport Response To External Biotic Stimulus Energy Homeostasis Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Defense Response To Virus Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Intestinal D-glucose Absorption Positive Regulation Of Type II Interferon Production Nickel Cation Transport	Membrane Plasma Membrane G Protein-coupled Receptor Activity Protein Binding Monoatomic Ion Transport SA Node Cell Action Potential Regulation Of Muscle System Process Endoplasmic Reticulum Membrane Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization G Protein-coupled Receptor Signaling Pathway Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Negative Regulation Of Muscle Hypertrophy Localization Within Membrane Response To Testosterone
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