IL27RA and STAT1

Number of citations of the paper that reports this interaction (PMID 12734330)
96

Data Source:
HPRD (in vitro, in vivo)

		IL27RA	STAT1
Gene Name		interleukin 27 receptor, alpha	signal transducer and activator of transcription 1, 91kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Axon Dendrite
	Molecular Function	Transmembrane Signaling Receptor Activity Interleukin-27 Receptor Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Tumor Necrosis Factor Receptor Binding Protein Binding Enzyme Binding CCR5 Chemokine Receptor Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Interferon-gamma Production Regulation Of Isotype Switching To IgG Isotypes Defense Response To Gram-positive Bacterium Interleukin-27-mediated Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Apoptotic Process JAK-STAT Cascade Response To Nutrient Blood Circulation Response To Mechanical Stimulus Viral Process Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Insulin Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Response To Cytokine Negative Regulation Of Macrophage Fusion Cellular Response To Interferon-beta Response To Drug Response To Hydrogen Peroxide Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Response To Peptide Hormone Endothelial Cell Migration Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation By Virus Of Viral Protein Levels In Host Cell Positive Regulation Of Smooth Muscle Cell Proliferation Response To CAMP Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Renal Tubule Development Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Metanephric Mesenchymal Cell Differentiation Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Pathways			Signaling by PDGF Signaling by FGFR in disease ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes Signaling by SCF-KIT Downstream signal transduction Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		4 interactors: EBI3 IL27 MAPK8 STAT1	103 interactors: ACTN4 ADRA1B AKT1 ATF3 BMX BRCA1 CAMK2D CAMK2G CASP3 CASP7 CCR1 CCR5 CREBBP CSE1L CSF2RB CXCR4 DCTN1 DDB1 DOT1L DUSP3 E2F1 EGFR EIF1AD EIF2AK2 ELP2 EP300 ERBB2 FADD FANCC FGFR3 FGFR4 FLT1 FOS FYN GFAP GNB2L1 GTF2I HADH HLA-B HSF1 HSP90AB1 IFNAR2 IFNGR1 IL27RA IL2RB IL2RG IRF1 IRF2 IRF9 JAK1 JAK2 JUN KDR KIT KPNA1 KPNA6 LCK LMO2 LZTR1 MAPK14 MAVS MCM3 MCM5 MDK ND4L NMI NOMO1 NOMO2 OTUD4 PDGFRA PDGFRB PIAS1 PIK3CA POR PRKCD PRMT1 PRMT3 PTK2 PTPN11 PTPN2 RAC1 RELA RPS6KA5 RXRA SHANK1 SPTAN1 SPTBN1 SRC STAT2 STAT3 STAT5A STAT5B SUMO4 SYK TNFRSF1A TNFRSF1B TRADD TYK2 UBC UBE2I VDR XPO1 ZNF467
Entrez ID		9466	6772
HPRD ID		09247	02777
Ensembl ID		ENSG00000104998	ENSG00000115415
Uniprot IDs		Q6UWB1	J3KPM9 P42224
PDB IDs			1BF5 1YVL 2KA6
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interferon-gamma Biosynthetic Process Immune Response Regulation Of Immune System Process Positive Regulation Of Interferon-gamma Production Response To Bacterium Positive Regulation Of Cytokine Biosynthetic Process Immune System Process Regulation Of Interferon-gamma Production Response To Other Organism Response To Biotic Stimulus Regulation Of Cytokine Biosynthetic Process Innate Immune Response Response To Hydrogen Peroxide Negative Regulation Of Macrophage Fusion Regulation Of Immune Response Regulation Of T Cell Proliferation Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Response To Reactive Oxygen Species Positive Regulation Of Metabolic Process Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Response To Mechanical Stimulus Regulation Of Innate Immune Response Defense Response JUN Phosphorylation Metanephric Mesenchymal Cell Differentiation Regulation Of T Cell Activation Positive Regulation Of Deacetylase Activity Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Response To Lipopolysaccharide Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Response To Molecule Of Bacterial Origin Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Determination Of Dorsal Identity Positive Regulation Of Cytokine Production Regulation Of Cell-cell Adhesion Mesenchymal Cell Differentiation Involved In Kidney Development Regulation Of Lymphocyte Activation Response To External Stimulus Regulation Of T-helper 1 Cell Differentiation Cell Proliferation Involved In Metanephros Development Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Cellular Response To Lipid Response To Oxidative Stress	Cellular Response To Organic Substance Response To Organic Substance Defense Response Innate Immune Response Response To Cytokine Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Cytokine-mediated Signaling Pathway Signal Transduction Regulation Of Immune Response Positive Regulation Of Cellular Metabolic Process Signaling Response To Stress Regulation Of Immune System Process Cell Communication Cellular Response To Stimulus Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Metabolic Process Response To Stimulus Positive Regulation Of Metabolic Process Protein Autophosphorylation Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Response To Growth Factor Regulation Of Signaling Response To External Stimulus Neurotrophin Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Peptidyl-amino Acid Modification Immune Response-regulating Signaling Pathway Viral Process Fc Receptor Signaling Pathway Positive Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process
Tagcloud ?		alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat2 stat5 stat5b stats yeast
Tagcloud (Difference) ?		alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat2 stat5 stat5b stats yeast
Tagcloud (Intersection) ?