IL27RA and SLC41A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IL27RA	SLC41A2
Description		interleukin 27 receptor subunit alpha	solute carrier family 41 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Interleukin-27 Receptor Activity	Protein Binding Monoatomic Cation Transmembrane Transporter Activity Magnesium Ion Transmembrane Transporter Activity Inorganic Cation Transmembrane Transporter Activity
	Biological Process	Negative Regulation Of Cellular Extravasation Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Immune Response Cell Surface Receptor Signaling Pathway Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Type II Interferon Production Negative Regulation Of Neuron Apoptotic Process Regulation Of Isotype Switching To IgG Isotypes Defense Response To Gram-positive Bacterium Interleukin-27-mediated Signaling Pathway Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T Cell Extravasation	Monoatomic Ion Transport Monoatomic Cation Transport Cobalt Ion Transport Iron Ion Transport Manganese Ion Transport Nickel Cation Transport Magnesium Ion Transport Metal Ion Transport Magnesium Ion Transmembrane Transport
Pathways		Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling	Metal ion SLC transporters
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)	Beta blocker survival benefit in heart failure with reduced ejection fraction (time to all cause mortality x beta blocker interaction) ( 33012170) Glucocorticoid receptor gene expression in B-cell precursor acute lymphoblastic leukaemia ( 33002292)
Interacting Genes		11 interacting genes: CLDN2 DEFB121 DERL3 EBI3 GALNT15 IL27 MAPK8 SLC41A2 SLC61A1 STAT1 YIPF6	31 interacting genes: AQP6 CD79A CLN5 CREB3 EBP ERGIC3 ERVFRD-1 FATE1 FNDC9 FUT3 GJA5 GJB5 GPR151 GPR42 GPX8 IGFBP5 IL27RA KASH5 KIR3DL3 LDLRAD1 LEUTX LIME1 LMNA LY6G6C LYVE1 MFF PDCD1LG2 PVR SHISAL1 SSMEM1 TMEM237
Entrez ID		9466	84102
HPRD ID		09247	15389
Ensembl ID		ENSG00000104998	ENSG00000136052
Uniprot IDs		Q6UWB1	Q96JW4
PDB IDs		7T5M 7U7N 8D85
Enriched GO Terms of Interacting Partners?		Interleukin-27 Receptor Binding JUN Phosphorylation Response To Stress Positive Regulation Of Defense Response To Virus By Host Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Regulation Of Defense Response To Virus By Host Response To Metformin Cytokine Activity Molybdate Ion Transmembrane Transporter Activity Molybdate Ion Transport Response To External Biotic Stimulus Energy Homeostasis Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Defense Response To Virus Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Intestinal D-glucose Absorption Positive Regulation Of Type II Interferon Production Nickel Cation Transport	Membrane B Cell Receptor Complex
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