ATXN7 and SPRY1

Number of citations of the paper that reports this interaction (PMID 21078624)
14

Data Source:
BioGRID (two hybrid)

		ATXN7	SPRY1
Gene Name		ataxin 7	sprouty homolog 1, antagonist of FGF signaling (Drosophila)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Microtubule Cytoskeleton Nuclear Matrix	Cytosol Plasma Membrane
	Molecular Function	Chromatin Binding Protein Binding	Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Chromatin Organization Transcription, DNA-templated Nucleus Organization Visual Perception Histone Deubiquitination Negative Regulation Of Phosphorylation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter	Establishment Of Mitotic Spindle Orientation Metanephros Development Ureteric Bud Development Organ Induction Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Ras GTPase Activity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Negative Regulation Of ERK1 And ERK2 Cascade
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		59 interactors: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN HIST1H3A JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SSFA2 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 VCP VWF	27 interactors: ATXN7 CACNA1A CREB5 GEMIN4 GRB2 HEXIM2 HOXA1 HRG KPNA2 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 LCE1B LCE2D MDFI MEOX2 NOTCH2NL OTX1 R3HDM2 SOCS4 SPRY2 STAT3 YY1
Entrez ID		6314	10252
HPRD ID		06365	06782
Ensembl ID		ENSG00000163635	ENSG00000164056
Uniprot IDs		O15265 Q9UPD8	O43609
PDB IDs		2KKR
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Response To Stimulus Cell-substrate Junction Assembly Cell-substrate Adhesion Platelet Degranulation Cellular Localization Protein Modification By Small Protein Conjugation Regulation Of Proteolysis Vesicle-mediated Transport Regulation Of Protein Metabolic Process Establishment Of Localization In Cell Cell Junction Assembly Protein Localization To Tight Junction Regulation Of Metabolic Process Histone Deubiquitination Regulation Of Cellular Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Response To Wounding Regulation Of Protein Catabolic Process Regulation Of Cell Death Protein Ubiquitination Protein Polyubiquitination Blood Coagulation Cellular Protein Modification Process Hemostasis Positive Regulation Of Proteolysis Focal Adhesion Assembly Cellular Component Assembly Protein Localization Extracellular Matrix Disassembly Platelet Activation Regulation Of Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Protein Complex Assembly Regulation Of Signaling Cellular Protein Metabolic Process Protein Localization To Cell Junction Cell Death Death Response To Stress Nervous System Development Positive Regulation Of Protein Catabolic Process Secretion By Cell Substrate Adhesion-dependent Cell Spreading Adherens Junction Assembly Protein Metabolic Process	Organ Development Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development System Development Developmental Process Anatomical Structure Morphogenesis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Negative Regulation Of ERBB Signaling Pathway Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Pattern Specification Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Embryonic Organ Development Regulation Of ERBB Signaling Pathway Regulation Of Phosphorylation Pons Development Anterior/posterior Pattern Specification Inner Ear Morphogenesis Sensory Organ Development Regulation Of Phosphorus Metabolic Process Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Organ Morphogenesis Embryonic Morphogenesis Ear Morphogenesis Negative Regulation Of Signal Transduction Metencephalon Development Embryo Development Transcription, DNA-templated Negative Regulation Of Signaling Negative Regulation Of Phosphorylation RNA Biosynthetic Process Hindbrain Development RNA Metabolic Process Regulation Of Gene Expression Response To Organic Substance Positive Regulation Of Transcription, DNA-templated Inner Ear Development Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity Keratinization Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		accounts asian ataxia ataxias atn1 atxn1 atxn2 atxn3 cag caucasians causal causative consortium ethnic expanded expansions explained geographical htt influenced modifier polyglutamine quadratic reflected replicated sister spinocerebellar tbp variability	adaptors coimmunoprecipitated comprises dok1 epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry2 stam2 transducing ut7epo validating
Tagcloud (Difference) ?		accounts asian ataxia ataxias atn1 atxn1 atxn2 atxn3 cag caucasians causal causative consortium ethnic expanded expansions explained geographical htt influenced modifier polyglutamine quadratic reflected replicated sister spinocerebellar tbp variability	adaptors coimmunoprecipitated comprises dok1 epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry2 stam2 transducing ut7epo validating
Tagcloud (Intersection) ?