UEVLD and RNF4

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		UEVLD	RNF4
Gene Name		UEV and lactate/malate dehyrogenase domains	ring finger protein 4
Image
Gene Ontology Annotations	Cellular Component	Extracellular Vesicular Exosome	Nucleus Cytoplasm PML Body
	Molecular Function	Molecular_function Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Ligase Activity Nucleosome Binding SUMO Polymer Binding Identical Protein Binding Androgen Receptor Binding
	Biological Process	Cellular Protein Modification Process Biological_process Protein Transport Cellular Carbohydrate Metabolic Process Oxidation-reduction Process	Transcription, DNA-templated Androgen Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Arsenic-containing Substance Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Regulation Of Spindle Assembly Regulation Of Kinetochore Assembly
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: DTX3 LRSAM1 RNF114 RNF4 TRAF6 UBC	37 interactors: AR ATXN1 ESR1 GSC2 HIST2H3C HMGA1 HNF4A IKBKG MECP2 PATZ1 PGR PML SKIL SP1 SRPK2 SUMO1 SUMO2 TBP TCF20 TRAIP TRIM28 TRPS1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2L6 UBE2T UBE2W UEVLD
Entrez ID		55293	6047
HPRD ID		15608	04167
Ensembl ID		ENSG00000151116	ENSG00000063978
Uniprot IDs		B4DIA9 Q8IX04	P78317
PDB IDs		2I6T 3DL2	2EA6 2XEU
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Autoubiquitination Cellular Protein Modification Process Intracellular Receptor Signaling Pathway Virion Assembly Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein K63-linked Ubiquitination Cellular Protein Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway JNK Cascade Ubiquitin-dependent Endocytosis Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Protein Catabolic Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Regulation Of Kinetochore Assembly Antigen Receptor-mediated Signaling Pathway Notch Signaling Pathway Activation Of MAPK Activity Activation Of Innate Immune Response Regulation Of Centromere Complex Assembly Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Viral Life Cycle Regulation Of Protein Ubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway	Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Transcription Initiation From RNA Polymerase II Promoter Protein K11-linked Ubiquitination DNA-templated Transcription, Initiation Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Protein Modification Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Modification-dependent Protein Catabolic Process RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Protein Catabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Heterocycle Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Aromatic Compound Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Cellular Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway ISG15-protein Conjugation
Tagcloud ?			barrier begins calculations catalyzed conjugating d117 deprotonation dimeric e3 elusive employing gets guiding kcal ligase ligases md mechanics nucleophilic oxyanion qm ring sumo2 thioester transfer ub ubch5a ubiquitylation universal
Tagcloud (Difference) ?			barrier begins calculations catalyzed conjugating d117 deprotonation dimeric e3 elusive employing gets guiding kcal ligase ligases md mechanics nucleophilic oxyanion qm ring sumo2 thioester transfer ub ubch5a ubiquitylation universal
Tagcloud (Intersection) ?