TRIM17 and LGALS8

Number of citations of the paper that reports this interaction (PubMedID 27693506)
53

Data Source:
BioGRID (pull down)

		TRIM17	LGALS8
Description		tripartite motif containing 17	galectin 8
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome	Extracellular Space Cytoplasm Cytosol Membrane Cytoplasmic Vesicle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Integrin Binding Protein Binding Carbohydrate Binding
	Biological Process	Autophagy Regulation Of Gene Expression Protein Ubiquitination Regulation Of Protein Localization Innate Immune Response Protein Autoubiquitination	Plasma Cell Differentiation Autophagy T Cell Costimulation Cellular Response To Virus Xenophagy Lymphatic Endothelial Cell Migration
Pathways		Interferon gamma signaling
Drugs
Diseases
GWAS		Non-Richardson's syndrome vs Richardson's syndrome in progressive supranuclear palsy ( 30066433)	Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		20 interacting genes: BAX HGS LGALS3 LGALS8 LRSAM1 MEOX2 MNAT1 TRAF6 TRIM39 TRIM41 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2H UBE2N UBE2W USP15	22 interacting genes: ANXA1 APEH BARD1 CALCOCO2 ERBB2 G3BP1 ITGA3 ITGA4 ITGB1 LRRK2 MEFV MID2 NACC1 NR1D2 NUFIP2 TRIM17 TRIM22 TRIM23 TRIM49 TRIM5 TRIM6 WBP2
Entrez ID		51127	3964
HPRD ID		05839	09356
Ensembl ID		ENSG00000162931	ENSG00000116977
Uniprot IDs		B3KP04 Q9Y577	O00214
PDB IDs			2YRO 2YV8 2YXS 3AP4 3AP5 3AP6 3AP7 3AP9 3APB 3OJB 3VKL 3VKM 3VKN 3VKO 4BMB 4BME 4FQZ 4GXL 4HAN 5GZC 5GZD 5GZE 5GZF 5GZG 5T7I 5T7S 5T7T 5T7U 5VWG 6W4Z 6Z6Y 7AEN 7ALS 7P1M 8CM8 8HL9 9FYJ
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Modification Process Protein Monoubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Transferase Activity Macromolecule Catabolic Process Ubiquitin Protein Ligase Activity Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Catabolic Process Protein Metabolic Process Proteolysis Negative Regulation Of Signal Transduction Protein Autoubiquitination Negative Regulation Of Signaling Negative Regulation Of Cell Communication Macromolecule Metabolic Process Response To Virus Cytosol Nucleus DNA Damage Response Response To Other Organism Protein Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Response To External Biotic Stimulus Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K63-linked Ubiquitination ATP Binding Positive Regulation Of Immune System Process Antiviral Innate Immune Response TOR Signaling Defense Response To Symbiont Negative Regulation Of TOR Signaling Regulation Of Signal Transduction Defense Response To Other Organism Proteasomal Protein Catabolic Process Regulation Of TORC1 Signaling Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Defense Response To Virus Negative Regulation Of Cellular Response To Growth Factor Stimulus	Ubiquitin Protein Ligase Activity Innate Immune Response Immune System Process Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of Autophagy Immune Response Positive Regulation Of Metabolic Process Defense Response Regulation Of Metabolic Process Response To Other Organism Integrin Alpha3-beta1 Complex Response To External Biotic Stimulus Integrin Alpha4-beta1 Complex Metal Ion Binding Positive Regulation Of Catabolic Process Integrin Complex Positive Regulation Of Macromolecule Metabolic Process Cytoplasm Response To Stress Regulation Of Autophagy Fibronectin Binding Protein Ubiquitination Zinc Ion Binding Regulation Of Protein Localization C-X3-C Chemokine Binding Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Defense Response To Virus Cell-cell Adhesion Mediated By Integrin Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Coreceptor Activity Regulation Of Defense Response Post-translational Protein Modification Positive Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Negative Regulation Of Vasoconstriction Response To Virus Neuromuscular Junction Mesodermal Cell Differentiation Protein-macromolecule Adaptor Activity Focal Adhesion Transferase Activity Regulation Of Rho Protein Signal Transduction Suppression Of Viral Release By Host Positive Regulation Of Immune System Process
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