NAT8 and ATP6V0E1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		NAT8	ATP6V0E1
Name		N-acetyltransferase 8 (putative)	ATPase H+ transporting V0 subunit e1
Structure		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Lysosomal Membrane Endosome Membrane Membrane Phagocytic Vesicle Membrane Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V0 Domain
	Molecular Function	L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding N-acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups L-cysteine-S-conjugate N-acetyltransferase Activity Protein-lysine-acetyltransferase Activity	Protein Binding ATPase-coupled Ion Transmembrane Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Glutathione Metabolic Process Positive Regulation Of Gene Expression Peptidyl-lysine N6-acetylation Amyloid Fibril Formation	Monoatomic Ion Transport Vacuolar Acidification Regulation Of Macroautophagy Transmembrane Transport Proton Transmembrane Transport
Pathways		Amyloid fiber formation	ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs		None	Tiludronic acid
GWAS		Chronic kidney disease ( 20383146 ) Creatinine levels ( 20383145 ) Estimated glomerular filtration rate ( 31015462 30604766 ) Glomerular filtration rate ( 23535967 ) Glomerular filtration rate (creatinine) ( 28452372 ) Hemoglobin levels ( 32327693 ) Macrovascular complications in type 2 diabetes ( 33430853 ) Metabolic traits ( 21886157 ) Metabolite levels ( 21931564 ) Metabolite levels (X-11787) ( 23934736 ) Serum metabolite concentrations in chronic kidney disease ( 33838163 29545352 ) Serum metabolite levels ( 33031748 24625756 23093944 ) Urinary metabolite levels in chronic kidney disease ( 29545352 31959995 ) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995 ) Urinary metabolite ratios in chronic kidney disease ( 29545352 ) Urinary metabolites ( 26352407 )	Body mass index ( 27455349 ) PR interval ( 32439900 )
Novel Interactors		7 novel interactors: CD3E CD59 NAT8B SLC40A1 SMYD5 SSB ST6GAL1	None recorded
Interacting Genes		31 interacting genes: AQP6 ARL13B ATP6V0E1 BIK CD79A CERS4 CREB3L1 EBP FAM209A FFAR2 GOLT1A GPR152 HSD17B13 JPH1 LEPROTL1 LMNA MTIF3 REEP2 SAR1A SLC10A6 SLC71A2 SMAD4 TGFBR1 TLCD4 TMEM143 TMEM14B TMEM31 TMX2 TRIM21 TSPAN31 YIPF4	19 interacting genes: APOD ATP6V1E1 CDIPT COL8A2 CXCL16 EMP1 GPR25 KIR2DL3 MAL2 MS4A13 MS4A4A NAT8 OPRM1 PLN SYT15 SYT15B TMEM218 TMEM254 YIPF6
Entrez ID		9027	8992
HPRD ID		08413	04894
Ensembl ID		ENSG00000144035	ENSG00000113732
Uniprot IDs		Q9UHE5	O15342
PDB IDs		Not available	6WLW 6WM2 6WM3 6WM4 7U4T 7UNF
GO Terms Enriched among Interactors		Membrane Endoplasmic Reticulum	None