NAT8 and SLC40A1

		NAT8	SLC40A1
Description		N-acetyltransferase 8 (putative)	solute carrier family 40 member 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Synaptic Vesicle Membrane Basolateral Plasma Membrane
	Molecular Function	L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding N-acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups L-cysteine-S-conjugate N-acetyltransferase Activity Protein-lysine-acetyltransferase Activity	Iron Ion Transmembrane Transporter Activity Protein Binding Ferrous Iron Transmembrane Transporter Activity Peptide Hormone Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Glutathione Metabolic Process Positive Regulation Of Gene Expression Peptidyl-lysine N6-acetylation Amyloid Fibril Formation	Lymphocyte Homeostasis Endothelium Development Transcription By RNA Polymerase II Monoatomic Ion Transport Iron Ion Transport Intracellular Iron Ion Homeostasis Apoptotic Process Iron Ion Transmembrane Transport Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Establishment Of Localization In Cell Transmembrane Transport Spleen Trabecula Formation Multicellular Organismal-level Iron Ion Homeostasis Iron Ion Export Across Plasma Membrane
Pathways		Amyloid fiber formation	Metal ion SLC transporters Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) Defective CP causes aceruloplasminemia (ACERULOP) Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) Iron uptake and transport
Drugs
Diseases			Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS		Chronic kidney disease ( 20383146) Creatinine levels ( 20383145) Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate ( 23535967) Glomerular filtration rate (creatinine) ( 28452372) Hemoglobin levels ( 32327693) Macrovascular complications in type 2 diabetes ( 33430853) Metabolic traits ( 21886157) Metabolite levels ( 21931564) Metabolite levels (X-11787) ( 23934736) Serum metabolite concentrations in chronic kidney disease ( 33838163 29545352) Serum metabolite levels ( 33031748 24625756 23093944) Urinary metabolite levels in chronic kidney disease ( 29545352 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Urinary metabolite ratios in chronic kidney disease ( 29545352) Urinary metabolites ( 26352407)	Bone fracture in osteoporosis ( 28580392) Hematocrit ( 32888494) Iron status biomarkers (ferritin levels) ( 25352340 33536631) Iron status biomarkers (total iron binding capacity) ( 28334935 33536631) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 28334935) Liver iron content ( 34128465) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252) Red blood cell count ( 27863252) Red cell distribution width ( 32888494) Restless legs syndrome ( 33239738)
Interacting Genes		31 interacting genes: AQP6 ARL13B ATP6V0E1 BIK CD79A CERS4 CREB3L1 EBP FAM209A FFAR2 GOLT1A GPR152 HSD17B13 JPH1 LEPROTL1 LMNA MTIF3 REEP2 SAR1A SLC10A6 SLC71A2 SMAD4 TGFBR1 TLCD4 TMEM143 TMEM14B TMEM31 TMX2 TRIM21 TSPAN31 YIPF4	3 interacting genes: GOLM1 HAMP SLC22A2
Entrez ID		9027	30061
HPRD ID		08413	05229
Ensembl ID		ENSG00000144035	ENSG00000138449
Uniprot IDs		Q9UHE5	Q9NP59
PDB IDs			6W4S 6WBV 8BZY 8C02 8C03 8DL6 8DL7 8DL8
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum	Acetylcholine Transport Histamine Uptake Pyrimidine Nucleoside Transmembrane Transporter Activity Export Across Plasma Membrane Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Amine Transmembrane Transporter Activity Spermidine Transmembrane Transporter Activity L-arginine Import Across Plasma Membrane Putrescine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Peptidyl-lysine N6-acetylation L-cysteine-S-conjugate N-acetyltransferase Activity Negative Regulation Of Iron Export Across Plasma Membrane Negative Regulation Of Iron Ion Transmembrane Transport Iron Ion Transmembrane Transporter Inhibitor Activity Negative Regulation Of Intestinal Absorption Negative Regulation Of Iron Ion Transport Iron Ion Export Across Plasma Membrane Transporter Regulator Activity Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Norepinephrine Uptake Xenobiotic Transport Across Blood-brain Barrier L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Regulation Of Iron Ion Transport Toxin Transmembrane Transporter Activity Choline Transmembrane Transporter Activity Polyamine Transmembrane Transport Serotonin Uptake Choline Transport Prostaglandin Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Norepinephrine Transport Histamine Transport L-arginine Transmembrane Transporter Activity Internal Peptidyl-lysine Acetylation Positive Regulation Of Receptor Catabolic Process Organic Cation Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity L-arginine Transmembrane Transport Amine Transport Catecholamine Uptake Dopamine Uptake Internal Protein Amino Acid Acetylation Azole Transmembrane Transport
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