NAT8 and TSPAN31

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NAT8	TSPAN31
Description		N-acetyltransferase 8 (putative)	tetraspanin 31
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Plasma Membrane Membrane
	Molecular Function	L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding N-acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups L-cysteine-S-conjugate N-acetyltransferase Activity Protein-lysine-acetyltransferase Activity	Protein Binding
	Biological Process	Glutathione Metabolic Process Positive Regulation Of Gene Expression Peptidyl-lysine N6-acetylation Amyloid Fibril Formation	Positive Regulation Of Cell Population Proliferation
Pathways		Amyloid fiber formation
Drugs
Diseases			Osteosarcoma
GWAS		Chronic kidney disease ( 20383146) Creatinine levels ( 20383145) Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate ( 23535967) Glomerular filtration rate (creatinine) ( 28452372) Hemoglobin levels ( 32327693) Macrovascular complications in type 2 diabetes ( 33430853) Metabolic traits ( 21886157) Metabolite levels ( 21931564) Metabolite levels (X-11787) ( 23934736) Serum metabolite concentrations in chronic kidney disease ( 33838163 29545352) Serum metabolite levels ( 33031748 24625756 23093944) Urinary metabolite levels in chronic kidney disease ( 29545352 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Urinary metabolite ratios in chronic kidney disease ( 29545352) Urinary metabolites ( 26352407)
Interacting Genes		31 interacting genes: AQP6 ARL13B ATP6V0E1 BIK CD79A CERS4 CREB3L1 EBP FAM209A FFAR2 GOLT1A GPR152 HSD17B13 JPH1 LEPROTL1 LMNA MTIF3 REEP2 SAR1A SLC10A6 SLC71A2 SMAD4 TGFBR1 TLCD4 TMEM143 TMEM14B TMEM31 TMX2 TRIM21 TSPAN31 YIPF4	4 interacting genes: BMP10 CMTM5 NAT8 TSPAN2
Entrez ID		9027	6302
HPRD ID		08413	01626
Ensembl ID		ENSG00000144035	ENSG00000135452
Uniprot IDs		Q9UHE5	B4DFJ7 F8VWE0 Q12999
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum	Internal Peptidyl-lysine Acetylation Peptidyl-lysine N6-acetylation L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor L-cysteine-S-conjugate N-acetyltransferase Activity Microglia Development Positive Regulation Of Sarcomere Organization Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Receptor Serine/threonine Kinase Binding Atrial Cardiac Muscle Tissue Morphogenesis Cytokine Activity Telethonin Binding Regulation Of Sarcomere Organization Internal Protein Amino Acid Acetylation Ventricular Cardiac Muscle Cell Development Peptidyl-lysine Acetylation Adult Heart Development Heart Trabecula Formation N-acetyltransferase Activity Astrocyte Development Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
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