NAT8 and ST6GAL1

		NAT8	ST6GAL1
Description		N-acetyltransferase 8 (putative)	ST6 beta-galactoside alpha-2,6-sialyltransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Golgi Membrane Extracellular Region Golgi Apparatus Membrane Golgi Cisterna Membrane
	Molecular Function	L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding N-acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups L-cysteine-S-conjugate N-acetyltransferase Activity Protein-lysine-acetyltransferase Activity	Beta-galactoside Alpha-2,6-sialyltransferase Activity Protein Binding Sialyltransferase Activity Transferase Activity Glycosyltransferase Activity Protein Homodimerization Activity
	Biological Process	Glutathione Metabolic Process Positive Regulation Of Gene Expression Peptidyl-lysine N6-acetylation Amyloid Fibril Formation	N-acetylneuraminate Metabolic Process Protein Glycosylation Protein O-linked Glycosylation Via N-acetyl-galactosamine Protein N-linked Glycosylation Via Asparagine Viral Protein Processing Sialylation
Pathways		Amyloid fiber formation	Sialic acid metabolism Maturation of protein 3a Maturation of spike protein Maturation of protein 3a N-Glycan antennae elongation Termination of O-glycan biosynthesis
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Creatinine levels ( 20383145) Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate ( 23535967) Glomerular filtration rate (creatinine) ( 28452372) Hemoglobin levels ( 32327693) Macrovascular complications in type 2 diabetes ( 33430853) Metabolic traits ( 21886157) Metabolite levels ( 21931564) Metabolite levels (X-11787) ( 23934736) Serum metabolite concentrations in chronic kidney disease ( 33838163 29545352) Serum metabolite levels ( 33031748 24625756 23093944) Urinary metabolite levels in chronic kidney disease ( 29545352 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Urinary metabolite ratios in chronic kidney disease ( 29545352) Urinary metabolites ( 26352407)	Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Albumin-globulin ratio ( 29403010) Drug-induced liver injury (flucloxacillin) ( 19483685) Eosinophil percentage of white cells ( 32888494) Esophageal cancer (squamous cell) ( 22960999) Heel bone mineral density x serum urate levels interaction ( 34046847) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) IgA nephropathy ( 26028593) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG monosialylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Immature fraction of reticulocytes ( 32888494) N-glycan levels ( 31163085) Non-albumin protein levels ( 29403010) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132) Thyroglobulin plasma levels ( 30929638) Type 2 diabetes ( 30718926 30297969 32499647 30054458 21874001)
Interacting Genes		31 interacting genes: AQP6 ARL13B ATP6V0E1 BIK CD79A CERS4 CREB3L1 EBP FAM209A FFAR2 GOLT1A GPR152 HSD17B13 JPH1 LEPROTL1 LMNA MTIF3 REEP2 SAR1A SLC10A6 SLC71A2 SMAD4 TGFBR1 TLCD4 TMEM143 TMEM14B TMEM31 TMX2 TRIM21 TSPAN31 YIPF4	1 interacting genes: CD22
Entrez ID		9027	6480
HPRD ID		08413	00184
Ensembl ID		ENSG00000144035	ENSG00000073849
Uniprot IDs		Q9UHE5	P15907
PDB IDs			4JS1 4JS2 6QVS 6QVT
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum	Peptidyl-lysine N6-acetylation L-cysteine-S-conjugate N-acetyltransferase Activity IgM Binding CD4 Receptor Binding Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Immunoglobulin Production Internal Protein Amino Acid Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor N-acetyltransferase Activity Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Calcium-mediated Signaling Neuronal Cell Body Membrane Sialic Acid Binding Protein-lysine-acetyltransferase Activity Amyloid Fibril Formation Protein Acetylation Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Glutathione Metabolic Process Regulation Of B Cell Proliferation Regulation Of Immunoglobulin Production Endoplasmic Reticulum-Golgi Intermediate Compartment Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Protein Phosphatase Binding Regulation Of Calcium-mediated Signaling
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