ATP6V0E1 and COL8A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ATP6V0E1	COL8A2
Description		ATPase H+ transporting V0 subunit e1	collagen type VIII alpha 2 chain
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Endosome Membrane Membrane Phagocytic Vesicle Membrane Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V0 Domain	Extracellular Region Collagen Trimer Collagen Type VIII Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Protein Binding ATPase-coupled Ion Transmembrane Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein-macromolecule Adaptor Activity
	Biological Process	Monoatomic Ion Transport Vacuolar Acidification Regulation Of Macroautophagy Transmembrane Transport Proton Transmembrane Transport	Angiogenesis Endothelial Cell Proliferation Cell Adhesion Extracellular Matrix Organization Camera-type Eye Morphogenesis Cell-cell Adhesion
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Collagen chain trimerization
Drugs		Tiludronic acid
Diseases			Fuchs corneal dystrophy (FECD); Fuchs endothelial corneal dystrophy Posterior polymorphous corneal dystrophy (PPCD)
GWAS		Body mass index ( 27455349) PR interval ( 32439900)	Central corneal thickness ( 29760442 32528159) Corneal structure ( 23291589) Early spontaneous preterm birth ( 31194736) Intraocular pressure ( 29617998 29785010 31959993)
Interacting Genes		19 interacting genes: APOD ATP6V1E1 CDIPT COL8A2 CXCL16 EMP1 GPR25 KIR2DL3 MAL2 MS4A13 MS4A4A NAT8 OPRM1 PLN SYT15 SYT15B TMEM218 TMEM254 YIPF6	18 interacting genes: ARL13B ATP6V0E1 BSND COL8A1 CREB3L1 CYB5R3 DARS2 FAM209A FNDC9 GPR152 GPX8 LMNA MUC1 PEX12 PLEKHO1 SGTA TFAM TMX2
Entrez ID		8992	1296
HPRD ID		04894	08347
Ensembl ID		ENSG00000113732	ENSG00000171812
Uniprot IDs		O15342	E9PP49 P25067
PDB IDs		6WLW 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?
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